Restrictive1

Question 1

In IPF type 1 alveolar cells release

Answer 1

TGF-beta1

Question 2

TGFbeta1 negatively regulates ________ in IPF

Answer 2

Telomerase

Question 3

Mutations in TERT/TERC

Answer 3

IPF

Question 4

Cobblestone surface. Sub pleural lesions in lower lobe

Answer 4

IPF

Question 5

Temporal heterogeneity

Answer 5

IPF

Question 6

Has cellular or fibrosing pattern

Answer 6

Nonspecific interstitial pneumonia

Question 7

Fibrosing pattern

Answer 7

Worse prognosis

Question 8

No fibroblastic foci or honeycomb lung

Answer 8

NSIP

Question 9

Good prognosis, can be treated with steriods

Answer 9

NSIP

Question 10

Response to infectious or inflammatory injury. Masson bodies

Answer 10

Cryptogenic organizing pneumonia

Question 11

Polyploid plugs of loose CT w/o temporal heterogeneity

Answer 11

COP

Question 12

Normal lung architecture > no interstitial fibrosis or honeycomb lung

Answer 12

COP

Question 13

Treat with steroid therapy for 6 months

Answer 13

COP

Question 14

Carbon particles in lung tissues. Accumulation of carbon pigment in macrophages along pulmonary lymphatics and LNs

Answer 14

Anthracosis

Question 15

Coal macules w/ ___________

Coal nodules with _______

Answer 15

Simple CWP
Carbon laden macrophages
Collagen

Question 16

Upper lobes and upper zones of lower lobes

Answer 16

Simple CWP

Question 17

Multiple blackened scars of fibrosis made of dense collagen, carbon pigment, and necrotic centers

Answer 17

Complicated CWP

Question 18

Pneumoconiosis and rheumatoid arthritis.

Rapidly developing lung nodules

Answer 18

Caplan syndrome

Question 19

Crystalline or amorphous form

Answer 19

Silicosis

Question 20

_________ form causes more fibrosis (especially Quartz) in silicosis

Answer 20

Crystalline

Question 21

Activates macrophages causing release of factors TNF, IL1, O2 derived free radicals

Answer 21

Silica

Question 22

Pale/dark nodules in upper lung zones early on

Answer 22

Silicosis

Question 23

Later nodules coalesce to form hard, collagenous scars surrounded by concentric layers of hyalinized collagen and a dense eggshell calcification capsule

Answer 23

Silicosis

Question 24

Increased susceptibility to TB

Answer 24

Silicosis

Question 25

Initial injury at bifurcations of small airways where fibers penetrate macrophages and activate them

Answer 25

Asbestos

Question 26

Act as tumor promoters by free radical production. Carcinogens bind to fibers

Answer 26

Asbestos

Question 27

Fibrosis around respiratory bronchioles, alveolar ducts, sacs, and alveoli

Answer 27

Asbestos

Question 28

Begins in lower lobes

Answer 28

Asbestos

Question 29

Found on diaphragm usually. Do not contain asbestos bodies

Answer 29

Pleural plaques

Question 30

Systemic. Dx of exclusion

Answer 30

Sarcoidosis

Question 31

Increased prevalence in women. Especially African Americans in SE USA

Answer 31

Sarcoidosis

Question 32

HLA subtypes in sarcoidosis

Answer 32

A1 and B8

Question 33

Repeated cycles of epithelial activation and injury. Fibroblastic foci

Answer 33

Idiopathic pulmonary fibrosis (UIP)