Results Flashcards
(4 cards)
What were your main two results?
1) AF senescent VSMCs in vessel wall LOWER in yes diagnosis of cSVD
- Mann Whitney p=0.0007
- But no significant difference in ratio
2) Higher ratio of senescent cells associated with LOWER cSVD score
- Spearman rank p=0.0480
- But no significant association fo AF
i.e. VSMC senescence is less frequently observed in cSVD arterioles than age matched healthy controls
How did your cSVD measures compare?
Yes diagnosis on PM of cSVD correlated with HIGHER cSVD score on histology
- Mann Whitney p=0.0149
- Increases confidence in both measures of cSVD
How did your senescence measures compare?
No significant association between ratio & AF on Pearson correlation
Ratio: assesses nuclear morphology & hence senescence
- human interpretation, exclusions, assess tissue morphology & preservation
- but vulnerable to bias and observer error
AF: computer generated quantification of abundance of heterochromatin
- reproductible, quick, consistent, not subject to bias
- but less specific as it didn’t exclude cells or lumen from calculations
How did other variables (than cSVD) compare to senescence?
- Sex: a possible confounding factor - no significant difference on Mann Whitney
- HTN: known risk factor - no signficant difference on Mann Whitney
- Age: research says correlates with senescnece - no significant association found on Pearson correlation
