Resuscitation / Critical Illness Flashcards

(27 cards)

1
Q

Variceal Bleeding

A

Pantoprazole 80mg stat then 8mg/hr

Ceftriaxone 1g or ciprofloxacin 400mg IV

TXA 1g

Octreotide 50microg IV bolus then 50microg/hr for 48hrs

Terlipressin 2mg IV every 4 hours

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2
Q

Massive PE Thrombolysis

A

Tenectaplase

Wt < 60kg: 6000u = 30mg

Wt 60 – 70kg: 7000u = 35mg

Wt 70 – 80kg: 8000u = 40mg

Wt 80 – 90kg: 9000u = 45mg

Wt > 90kg: 10000u = 50mg

Alteplase

Wt > 65kg 10mg IV bolus then 90mg infusion over 2 hours

Wt < 65kg 10mg IV bolus then 1.5mg/kg (max 90mg) over 2 hours

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3
Q

Local Anaesthetic Toxicity

A

IV Fluids +/- inotropes for hypotension

Midazolam for seizures

Sodium Bicarbonate 1-2mmol/kg every 1-2 minutes for cardiac arrythmia (Na channel blockade) ……… buvipicaine

Intralipid 20% 1.5ml/kg over 1 minute then infusion 0.25 ml/kg/hr

Methylene Blue 1-2 mg/kg IV over 5 minutes for methemoglobinemia……….Prilocaine

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4
Q

Contraindications to NIV

A
  • patient wishes
  • patient compliance
  • adequate respiratory effort
  • vomiting
  • pneumothorax
  • bowel obstruction
  • unable to fit mask due to anatomy or trauma
  • decreased GCS
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5
Q

Lung Protective Ventilation - ARDS

A

ALWAYS VT of 4-8 ML/KG

ARDS – high RR 20-26, HIGH PEEP 10-15, I:E 1:1

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6
Q

Asthma Ventilation

A

ALWAYS VT of 4-8 ML/KG

ASTHMA – low RR 6-8, LOW PEEP 0-5, I:E 1:5

ensure plateau pressure < 30

expect high airway (peak) pressures

expect high pCO2 (prioritise oxygenation)

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7
Q

Predictors of difficult airway

A

Short thyromental distance / anterior larynx

Small / recessed mandible

Mouth opening < 2cm

Poor neck ROM – e.g. RA, Ankylosing Spondylysis

Pregnancy

Obesity

History of difficult intubation

Mallamnpatti Score >3

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8
Q

Triggers for laryngospasm

A
  • intraoral injury or procedure
  • stimulation of the posterior pharynx
  • vomiting/aspiration
  • ketamine
  • anaphylaxis
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9
Q

steps to manage laryngospasm

A
  1. Apply O2 15lm BVM
  2. Apply painful stimulus to angle of mandibe + jaw thrust
  3. Attempt BVM ventilation – PPV with peep valve
  4. Give deeper sedation – use propofol
  5. Give sux IV 0.5mg/kg continue BVM
  6. Give sux 1 mg/kg IV and intubate
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10
Q

Biers Block drug + dose

A

Prilocaine 0.5%, 3mg/kg IV

duration = 20-30mins

toxic effects = seizure, decreased GCS, metHb

– quite safe cardiotoxicity profile – unlikely hypotension or arrythmia

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11
Q

contraindications to Biers Block

A

Uncooperative patient – must be able to tolerate cuff

Allergy to prilocaine

Unable to gain 2x IV access

Sickle cell disease

Raynauds

Open fracture

Vascular complication from the fracture

HTN, SBP > 200

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12
Q

Biers Block - complications

A

Seizure management

Abandon the procedure

Apply 15lmin O2 via NRBM, place on side, manage airway Midazolam 5mg IV alloquot – repeat q5mins

Check cuff still inflated – increase to max pressure

IV fluid 10ml/kg bolus

Monitor on cardiac monitor for arrythmias

Move the patient to resus if not there already

Check and correct hypoglycaemia

Intralipid not really for prilocaine – more bupivacaine

consider methaemoglobinaemia - administer methylene blue

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13
Q

Sore Throat + Fever + airway obstruction, causes?

A

Epiglottitis

Anaphylaxis

Peritonsillar abscess

Ludwigs angina – less likely

Retropharyngeal abscess

angiooedema

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14
Q

Adrenalin routes + doses for anaphylaxis

A

IM 10microg/kg of 1:1000 up to 500microg = 0.5ml

IV 1mcg/kg of 1:10000 bolus if peri-arrest, i

nfusion = 0.05 – 0.1 mcg/kg/min

Neb 5mg = 5ml of 1:1000

ET route 100mcg/kg in cardiac arrest

IO same as IV Cardiac arrest = 10mcg/kg IV every second round

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15
Q

Indications for intubation in Trauma

A
  • GCS < 9
  • restless patient needing procedure e.g. CT scan
  • combative patient
  • elective hypocapnia required (“controlled” PCO2 – low-normal range)
  • hypoxaemia
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16
Q

ASA Class

A
    1. Healthy patient, no medical problems
    1. Mild systemic disease e.g. hypertension
    1. Severe systemic disease, but not incapacitating
    1. Severe systemic disease that is a constant threat to life
    1. Moribund, expected to live less than 24 hours irrespective of operation
  • E operation is an emergency
17
Q

Anaesthetic risk in pregnancy

A
  • 10% incidence of spontaneous miscarriage if surgery performed in first trimester -6% overall
  • significantly increased in later pregnancy
  • difficult intubation -larger breasts -oedema may be present (especially in pre-eclampsia)
  • higher risk of aspiration -abdominal distension -relaxation of the lower oesophageal sphincter
  • higher gastric acidity
  • higher rates of oxygen desaturation -higher baseline oxygen consumption -lower FRC and oxygen reserve capacity -impaired diagphramatic movement
18
Q

Complications of NIV

A
  • facial skin necrosis -pressure sores
  • conjunctivitis
  • gastric dilatation
  • aspiration
  • pneumothorax
19
Q

RSI : HEAD INJURY

A

•fentanyl 0.5 – 1 µg/kg or lignocaine (lidocaine) 1 mg/kg IV

  • may blunt the increase in ICP that occurs with instrumentation of the larynx
  • usually given 1 - 2 minutes prior to other agents
  • lignocaine (lidocaine) rarely used in Australasia for this purpose

•thiopentone 1.5 -3 mg/kg

  • reduce dose or use fentanyl if hypotensive
  • may also lower ICP

•rocuronium 1.2 - 1.5 mg/kg or suxamethonium 1 - 1.5 mg/kg (atropine handy in case of bradycardia)

  • rocuronium does not cause an increase in ICP, however paralysis will be prolonged making subsequent neurological assessment difficult
  • advantages of rapid paralysis outweigh the potential disadvantage of a brief increase in ICP with suxamethonium

DUNN

20
Q

RSI: HYPOTENSION / SHOCK

A

Induction agent

•induction with ketamine 1.5-2 mg/kg, or fentanyl 3µg/kg may prevent further deterioration in cardiovascular status

•etomidate 0.2-0.3 mg/kg is another alternative, if available

•thiopentone

  • best avoided if possible
  • or reduce dose to 1.5 mg/kg or less

•propofol

  • intermediate risk of worsening hypotension
  • reduce dose to 1 mg/kg, if possible

DUNN

21
Q

RSI: C-SPINE INJURY

A

Cervical spine injury

Indications for intubation

  • concurrent head injury
  • respiratory failure
  • cord injury > C6 (phrenic nerve)
  • 40% of patients with lesions at C3 will require longer term mechanical ventilation
  • 15% of patients with lesions at C4 or C5 need longer term ventilatory support
  • associated chest injury
  • aspiration

Options

  • get skilled assistance if assessed as potential difficult intubation
  • orotracheal intubation with manual in line stabilisation (as described above)
  • the method of choice – high success rate
  • safe if performed properly
  • causes more movement in the upper Cx spine than the lower spine

•video assisted intubation

  • use whenever possible
  • associated with less neck movement than traditional orotracheal intubation

•use an ETT over a bougie technique

  • may result in less Cx spine movement
  • only the posterior cords need to be visualised to pass the bougie, whereas most of the cords need to be seen to pass the ETT under vision
  • fibreoptic assisted nasal intubation
  • cricothyroidotomy
  • not required routinely
  • does not cause significant movement in the unstable spine
  • movement greater at lower spine than upper
  • tracheostomy
  • retrograde intubation
  • blind nasal intubation

-contra-indicated as very difficult to perform without head movement

22
Q

RSI: Maxillofacial trauma

A

Maxillofacial trauma

  • may be uncooperative
  • may obstruct when sedated or following analgesia
  • hypoxic
  • bleeding

Techniques

  • get skilled help!
  • fibre-optic intubation may be safest (oral route after topical LA)
  • consider option of intubation in theatre with surgeon nearby
  • RSI
  • adequate suction vital
  • good laryngoscopes x 3

-may fail if covered with blood

•prepare for a surgical airway

Deformed facial anatomy

  • large mask size
  • assistant to compress cheek or seal defect if open wound
  • laryngeal mask
  • rapid sequence induction
  • surgical airway if not successful

Facial burns

  • intubate early as severe oedema may develop
  • nasotracheal intubation - using fibreoptic laryngoscope is the method of choice if airway compromise already present
23
Q

Lateral canthotomy

A

Lateral canthotomy

  • surgical procedure used to compress the orbit
  • if intraocular pressure > retinal artery pressure for more than 2 hours, the retina will start to be permanently damaged
  • rarely required
  • most common situations are post-traumatic
  • other situations
  • infection
  • tumour
  • spontaneous haemorrhage

INDICATIONS:

-increased intraorbital pressure causing compromise of the retinal blood supply

-visual loss

-afferent pupillary defect

-proptosis

-hard globe on palpation (IOP > 40 mmHg)

anatomy

  • medial and lateral canthal ligaments prevent globe from extrusion from the orbit
  • originate medially and laterally from bony wall
  • Y shaped and divide on the surface of the globe into inferior and superior ligaments

procedure

  • local anaesthetic infiltration of lateral canthus
  • incise skin over lateral canthus towards bony orbit
  • retract lower lid
  • divide inferior lateral canthal ligament
  • divide superior lateral canthal ligament if pressure does not drop sufficiently
24
Q

DROWNING - Pathophysiology

A

Phases

  • voluntary breath holding
  • involuntary laryngospasm secondary to liquid in oropharynx / larynx
  • hypoxia, hypercarbia, acidosis
  • may swallow large amounts water
  • active respiratory movements but no gas exchange because of laryngospasm
  • worsening hypoxia results in laryngospasm abating
  • subsequent active breathing of liquid (volume very variable)
  • changes in lungs, body fluids, acid-base and electrolyte balance
  • washout of surfactant, pulmonary hypertension and shunting contribute to hypoxia
  • additional changes if immersion is in cold water
  • tissue hypoxia leads to multi-organ dysfunction and death

Pathophysiology

  • abnormal gas exchange induced by pulmonary injury
  • results in
  • severe hypoxia
  • cerebral oedema

•previously estimated that 10% of human drowning victims die without aspirating liquid

-this has now been challenged as water was found in 99% of cases in a large study of drowned victims

•absence of water aspiration at autopsy probably means the death was not due to drowning

-water does not passively seep into lungs after death

•aspiration of other material may occur

  • vomit
  • sand
  • mud
  • algae

•arterial oxygenation is profoundly affected when as little as 1 to 2.2 mL/kg of water are aspirated

-aspiration of water results in persistent hypoxia even if ventilation and circulation is restored

•the end result of drowning in both fresh or sea water is

  • pulmonary oedema
  • decreased pulmonary compliance
  • increased V/Q mismatch
  • most drowning victims do not aspirate enough fluid to cause life-threatening changes in blood volume
  • life-threatening changes in serum electrolyte concentrations seldom seen, regardless of the type of water

-except in the Dead Sea!

  • significant changes in Hb / Ht and renal function are rarely seen
  • most drowning victims suffer a period of unconsciousness due to cerebral hypoxia
  • patients who are awake and oriented on arrival in ED survive neurologically intact if management of pulmonary complications are successful
  • patients who present in coma have a worse prognosis
  • effectiveness of cerebral resuscitation measures need further evaluation in drowning
25
DROWNING Prognosis
**Prognosis** * no clinical score 100% accurately predicts which patients will survive the drowning event * submersion time correlates with survival in some studies - may be difficult to determine accurately - 85% of survivors with good neurological recovery are submerged \< 6 minutes - 7.5% for 6–10 minutes - 5% for 11–59 minutes - \<1% greater than 60 minutes - \> 10 minutes is considered a possible cut-off point for non-survival * efficiency of initial resuscitation influences outcome * water temperature no longer believed to influence outcome * non-reactive pupils and a GCS of 5 on arrival in ICU are the best independent predictors of a poor neurological outcome * 75% of survivors have good neurological outcome **Orlowski scale** * age \< 3 years * estimated submersion \> 5 minutes * no attempted resuscitation in the first 10 minutes after rescue * coma on arrival at the ED * metabolic acidosis on arrival with pH \< 7.10 * outcome - 90% chance of good recovery if \< 3 of the above present - 5% recovery if \> 3 present **Glasgow coma scale** * patients with decorticate / decerebrate / flaccid response at 2 - 6 hours after rescue rarely survive or survive only with significant neurological impairment * GCS of 5 = 80% risk of death / severe deficit * patients with neurological improvement within 2 - 6 hours following rescue often recover with little or no neurological deficit * 34% of comatose patients on arrival in ED die after presentation * children comatose on arrival in ED - 45% survive with normal brain function - 15% survive with incapacitating brain damage - 40% die * patients with neurological improvement within 2 - 6 hours following rescue often recover with little or no neurological deficit * time of first spontaneous respiratory effort - if \< 15 - 30 minutes after rescue, \< 10% have significant neurological deficit - if 60 - 120 minutes after rescue, 50 - 80% chance of sustaining serious neurological damage **Other prognostic factors** * on arrival in ED * good prognosis -spontaneous respiration and heart beat •poor prognosis - resuscitation duration \> 25 minutes - VT or VF on initial ECG - fixed dilated pupils - cardio or respiratory arrest **Prognosis in drowning and hypothermia** * patients with a core temperature \> 33o C who have not ingested alcohol or other drugs and who do not make any respiratory effort \< 40 minutes of rescue are unlikely to survive without significant brain damage * in a study of 98 children with open water immersion and body temperature of \< 34C, no child survived with good neurological outcome after \> 25 min. of CPR * chance of survival is related to rapidity of onset of hypothermia -the more rapidly cooled = better chance of resuscitation •water temperature rarely cold enough in Australia to provide protective effect from immersion **When CPR is likely to be futile** * water temperature \> 6C and immersion time \> 30 min * water temperature \< 6C and immersion time \> 90 min * submersion \> 10 min without hypothermia (nearly all cases in Australia) * persistent apnoea and asystole after 1 hour of post-rescue CPR provided not hypothermic * serum K+ \> 11 mmol/L * blood is frozen
26
DROWNING - Assessment
**HISTORY:** ## Footnote **Precipitating event** * syncope * seizure * drugs / alcohol * hyperventilation * trauma **Type of immersion** * the type and temperature of the water * the amount and type of water contamination * time of submersion and removal, if known * conscious state on removal from water **Prehospital care** * bystander resuscitation / details (who administered and method of CPR) * time of EMS arrival and commencement of resuscitation * vital signs and conscious state on arrival of EMS - breathing spontaneously - palpable pulse - GCS * vomiting during rescue or resuscitation (very common) * transportation time **Past history** * epilepsy * alcohol abuse * drug ingestion **NAI** •consider non-accidental injury or neglect in children
27
DROWNING - MANAGEMENT
**Management** **•follow standard ACLS protocols** - chest compressions are ineffective in the water - immediately transfer to land or a boat - attempt ventilation if unale to get patient out of the water - consider additional initial ventilations as the injured lung may be harder to ventilate **Spinal immobilisation** •routine cervical spine immobilisation is not necessary -potentially hazardous as vomiting common after drowning, particularly when CPR / ventilation provided •immobilise if circumstances indicate trauma is likely - history of diving - use of a water slide - motor vehicle crash - signs of injury - alcohol intoxication •spinal injury in drowning is associated with clinical features of serious injury **Respiratory support** * focus of initial hospital care * high risk of ARDS up to 72 hours following drowning * alert, cooperative patients do not routinely require tracheal intubation * intubate if pulmonary pathology does not respond to supplemental oxygen and CPAP * if intubation required, support with controlled mechanical ventilation and PEEP - use pressure-support ventilation starting at 10 cm H2O - titrate CPAP or PEEP to maintain SpO2 ≥ 95%, using the lowest possible FiO2 **Other pulmonary therapy** * antibiotics indicated if features of infection develop, guided by culture results * consider antibiotics in paediatric pool drowning (due to aspiration of Pneumococcus in patient's pharynx) -although the evidence for efficacy is weak * use broad spectrum antibiotics prior to culture results if submersion was in grossly contaminated water (e.g. sewerage) * treat bronchospasm * glucocorticoids ineffective for pulmonary complications in drowning **Circulatory support** •initial intravenous fluid therapy should be normal saline -avoid hypotonic solutions •hypovolaemia may be present following prolonged immersion, due to the hydrostatic pressure of the water on the body -correct hypovolaemia but avoid excessive volumes due to the risk of pulmonary oedema * monitor serum electrolytes * invasive monitoring if concerned about intravascular volume -prolonged inotropic support rarely needed •consider ECMO if available **Cerebral resuscitation** * little research in this area * restoration of spontaneous circulation a priority * intracranial pressure management - controversial area - raised ICP may reflect hypoxic injury and treatment may not alter outcome - consider ICP monitor if persistent coma despite correction of reversible causes - target pCO2 25-30 mmHg if ICP raised •induced hypothermia - no convincing evidence for efficacy in drowning - in the comatose patient with spontaneous circulation maintenance of T \< 36C (as for post cardiac arrest) is reasonable •other - avoid hypoxia - treat seizures - prevent hyperthermia at all times - maintain normoglycaemia - insufficient evidence for other specific neuroresuscitative measures **Hypothermia** •manage according to standard protocols