Reticular formation Flashcards
(45 cards)
What is the Reticular Formation?
An ill-defined diffuse network of neurons signaling via the medulla, pons, and midbrain.
What types of neurons surround the Reticular Formation?
Motor, sensory, and visceral (autonomic) neurons.
What are the characteristics of dendrites in the Reticular Formation?
Long, straight, dorsal-ventral.
What is the structure of axons in the Reticular Formation?
Very long, bifurcated into descending and ascending, with numerous collateral branches.
What is the function of the Locus coeruleus?
Contains norepinephrine-secreting neurons.
What are the three subdivisions of catecholamines?
- Dopamine
- Norepinephrine
- Epinephrine
What is the precursor for catecholamines?
Tyrosine.
What are the functions of the Reticular Formation?
- Alertness
- Sleep process
- Inhibit pain
- Regulate muscle tone and movement
- Regulate vital signs against heart and lung
What are the three functional zones of the Reticular Formation?
- Lateral zone
- Median (raphe) zone
- Medial zone
What is the role of the Ascending Reticular Activating System (ARAS)?
Essential for regulating arousal, consciousness, and attention.
How does the Parvocellular nucleus contribute to ARAS?
Processes signals from various sources and releases glutamate.
What neurotransmitter does the Pedunculopontine nucleus release?
Acetylcholine (Ach)., glutamate, GABA
What is the first step in the ARAS process?
Sensory input from the lateral zone.
What happens in Step 2 of ARAS?
Connection to the medial zone (arousal center).
What does the medial zone activate in ARAS?
The thalamus.
What is the final step of ARAS that leads to behavioral arousal?
Cortical response and activation of cortical neurons.
What are the four pathways involved in maintaining alertness?
- Noradrenergic pathway (Locus coeruleus)
- Serotonergic pathway (Raphe nucleus)
- Histaminergic pathway (Hypothalamus)
- Orexin pathway (Hypothalamus)
What is the role of the noradrenergic pathway?
Sends signals to locus coeruleus to release norepinephrine, maintaining alertness.
What is the function of the serotonergic pathway?
Parvocellular neurons send signals to the median zone (raphe nucleus), which releases serotonin to promote alertness.
What does the histaminergic pathway do?
Releases histamine from the tuberomammillary nucleus to promote alertness.
What is the role of the orexin pathway?
Involved in wakefulness and preventing sudden sleep.
What tools are used to assess consciousness?
- Electroencephalogram (EEG)
- Glasgow Coma Scale (GCS)
What does a Glasgow Coma Score (GCS) of 8 or below indicate?
Severe impairment of consciousness.