reumato

Question 1

disease modifying antirheumatic drugs

Answer 1

methotrexate; folate antimetabolite, hepatotoxicity, stomatitis, cytopenias = folate supplements

leflunomide; pyridine synthesis inhibitor. hepatotoxicity cytopenia

hydroxychloroquine ; TNF and IL1 suppressor , retinopathy

sulfasalazine, TNF and IL1 suppressor, hepatotoxicity stomatitis, hemolytic anemia

TNF inhibitors ( adali, certo, etanercept, goli, infliximab); Infection, demyelination, CFF, malignancy interfron gamma release assay

Question 2

conditions associated with ankylosing spondylitis

Answer 2

one of them is restrictive lung disease due to limited costovertebral joint motion ,…acute anterior uveitis, aortic regurgitation, apical pulmonary fibrosis, IgA nephropathy

these patients normally have the same life expectancy linked normal population

Question 3

transplant and gout

Answer 3

transplant patients take cyclosporine which decreases uric acid excretion

Question 4

systemic sclerosis clinical manifestation autoantibodies and comlications

Answer 4

(skin , extremities: arthralgia and myalgia and contracture)gastrointestinal; esophageal dysmotility, dysphagia, acid reflux, lung; dyspnea, dry cough, vascular raynaud )

ANA, anti- topoisomerase type 1 (anti- scl70)
anticentromere( limited SSc)

lungs ( interstitial lung disease, pulmonary arterial HTN, kidneys: HTN( treatment : ace and nitroproside, scleroderma renal crisis, heart; myocardial fibrosis, pericarditis , pericardial effusion

Ace inhibitors are not in the treatment of AKI only one exception and that is it

Question 5

infection susceptibility of hemochromatosis

Answer 5

vibrio vulnificus and yersinia entrocolitica

Question 6

scaphoid fracture

Answer 6

if suspected even without pain : one week later another x ray or MRI or Radioscintigraphy

Question 7

autoantibodies for myositis

Answer 7

ana anti jo 1

Question 8

sjogren syndrome

Answer 8

anto ro LA (SS,A- AA,B)