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Flashcards in Reverse Pharm-GI Deck (11):
1

H2 blockers (4/suffix)

Reversible block of histamine H2 receptors leading to decr. H+ secretion by parietal cells

Peptic ulcer, gastritis, mild GERD

1=potent inhib. of P450, antiandrogenic effects, can cross BBB and placenta

1/2=decr. renal excretin of creatinine

3/4=free of s/x

cimetidine (1), ranitidine (2), famotidine, and nizatidine?

2

PPIs (5 or suffix)

Irreversibly inhibit H+/K+ ATPase in stomach parietal cells

peptic ulcer, gastritis, esophageal reflux, and ZE syndrome

Incr. risk of C. diff, pneumonia
Decr. serum Mg2+ w/ long term use

omeprazole, lansoprazole, esomeprazole, pantoprazole, and dexlansoprazole

3

(2) Mechanism: bind to ulcer base, providing physical protection and allowing HCO3 secretion to reestablish pH gradient in mucosal layer.

Incr. ulcer healing
Traveler's diarrhea

bismuth, sucralfate

4

PGE1 analog
incr. production and secretion of gastric mucosa barrier
Decr. acid production

PRevention of NSAID induced peptic ulcers
maintenance of PDA
Off label for induction of labor (ripens cervix)

Diarrhea.
CI=women of childbearing potential (abortifacient)

Misoprostol

5

Long acting somatostatin analong
Inhibits action of many splanchnic vasoconstriction hormones

Acute variceal bleeds
acromegaly
VIPoma
Carcinoid tumors

Nausea, cramps, steatorrhea

octreotide

6

Antacids (3)

Can affect absorption, bioavailability, or urinary excretion of other drugs by altering gastric acid or urinary pH or by delaying gastric emptying
All can cause hypokalemia

1=constipation
2=hypercalcemia, rebound acid incr.
3=diarrhea

Aluminum hydroxide (1), calcium carbonate (2), and magnesium hydroxide (3)

7

Osmotic laxatives

Provide osmotic load to draw water into GI lumen

Constipation
1=hepatic encephalopathy (trapping urea as NH4+)

Diarrhea, dehydration; abuse by bulimics

magnesium hydroxide magnesium citrate, polyethylene glycol, and lactulose (1)

8

Sulfapyridine (antibacterial) and 5 aminosalicylic acid (anti-inflammatory)

Activated by colonic bacteria

UC, Crohns disease (colitis component)

Malaise, nausea, sulfonamide toxicity, reversible oligospermia

sulfasalazine

9

5-HT3 antagonist;
Decr. vagal stimulation
Powerful central acting antiemetic

Control vomiting postoperatively
Cancer chemo anti-emetic

Headache, constipation, QT prolongation

ondansetron

10

D2 receptor antagonist
Incr. resting tone, contractility, LES tone, motility.
Does not influence colon transport time

Diabetic and postsurgery gastroparesis,
antiemetic

Incr. parkinsonian effects, tardive dyskinesia
REstlessness, drowsiness, fatigue, depression
diarrhea
drug interaction w/ digoxin and diabetic agents

CI: Small bowel obstruction or parkinson disease

Metoclopramide

11

Inhibits gastric and pancreatic lipase leading to decr. breakdown and absorption of dietary fats

Weight loss

Steatorrhea, decr. absorption of fat soluble vitamins

Orlistat