Reversible Cell Injury

Question 1

What is reversible cell injury ?

Answer 1

Mild cellular injury that the cell can recover after the removal of the adverse influence

Question 2

Reversible cell injury ( ultra structural ) :

Answer 2

1. Blabbing of plasma membrane , distortion or blunting of microvilli , loosening of intercellular attachment
2. Mitochondrial swelling
3. ER is hypertrophied and increased activity , SER dilation , Dissociation of polysomes and ditachment of ribosomes of RER .
4. Nuclear clumping of chromatin

Question 3

Reversible cell injury (light microscope) :

Answer 3

1. Cellular swelling
2. Fatty change

Question 4

Cellular swelling other names :

Answer 4

Cloudy swelling = hydropic change = vacuole degeneration

Question 5

Cellular swelling mechanism :

Answer 5

1. Failure of energy-dependent ion pumps in the plasma membrane
2. Inability to maintain ion and fluid homeostasis
3. Accumulation of Na and water within the cytoplasm

Question 6

Cellular swelling appearance of tissue ( grossly and microscopically ) :

Answer 6

Grossly : pallor , swelling and increased weight of organ .
Microscopically : small , clear vacuoles within the cytoplasm ( segments of endoplasmic reticulum )

Question 7

Types of injury involved in Fatty change :

Answer 7

Hypoxic , toxic and metabolic injury

Question 8

Fatty change characteristic :

Answer 8

Vacuoles in the cytoplasm of cells participating in fat metabolism ( hepatocytes , myocardial cells )

Question 9

Appearance of fatty change in the liver : ( Grossly and microscopically )

Answer 9

Grossly : bright yellow , soft ,greasy and enlarges to (3-6 kg)

Question 10

All stresses and noxious influences exert their effects firstly :

Answer 10

At the molecular or boichemical level

Question 11

Other conditions that fatty change is involved in :

Answer 11

1. Starvation
2. Alcoholic or viral hepatitis