REVIEW QUESTIONS

Question 1

Bleeding Time is used to evaluate the activity of:

Answer 1

Platelets

Question 2

Which of the following test results is normal in a patient with classic von Willebrand’s disease?

Answer 2

Platelet count

Question 3

No bleeding is observed in deficiency of which of the following factors?

Answer 3

XII

Question 4

Hemolytic Uremic syndrome is associated with:

Answer 4

E.coli

Question 5

Coagulation Factors affected by Coumarin Drugs:

Answer 5

II, VII, IX, X

Question 6

Thrombotic thrombocytopenic purpura is characterized by:

Answer 6

Increase platelet aggregation

Question 7

A protein that plays a vital role in both coagulation and platelet aggregation:

Answer 7

I

Question 8

The defect characterizing Gray’s Syndrome:

Answer 8

Alpha Granule

Question 9

Factor XIII is activated by which factor?

Answer 9

IIa

Question 10

Factor V is a cofactor to factor X to activate factor II

Answer 10

True

Question 11

What clotting factors are inhibited by Protein S

Answer 11

V and VIII

Question 12

What is the second phase of secondary hemostasis?

Answer 12

Activation of Factor X

Question 13

Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet count is 8,000/uL. What is likely the explanation?

Answer 13

Isoimmune Neonatal Thrombocytopenia

Question 14

When performing platelet aggregation studies, which is most likely associated with Bernard Soulier Syndrome?

Answer 14

Normal to Epinephrine, Decreased to Ristocetin

Question 15

Which of the following is a characteristics of acute idiopathic thrombocytopenic purpura?

Answer 15

Spontaneous remission within a few weeks

Question 16

Factor XIII is a serine protease

Answer 16

False

Question 17

Which of the following inhibitors inhibit Factor IIa?

Answer 17

Both; Protein C and Antithrombin III

Question 18

Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?

Answer 18

Autoimmune Disease

Question 19

TAFI target protein:

Answer 19

Fibrin

Question 20

Which step requires calcium?

Answer 20

Factor XIII activation

Question 21

Giant platelet is associated with which condition:

Answer 21

Bernard Soulier Syndrome

Question 22

Platelet abnormality will affect both bleeding time and clotting time

Answer 22

True

Question 23

Which of the following is associated with post transfusion purpura?

Answer 23

Immune mediated thrombocytopenia/Alloantibodies

Question 24

Thiazide diuretics results to:

Answer 24

Decreased Platelet Production

Question 25

Which of the following Factors is used only in the Extrinsic Coagulation Pathway?

Answer 25

VII

Question 26

Hereditary hemorrhagic telangectasia is a disorder of

Answer 26

Connective Tissue

Question 27

Which of the following coagulation factors is considered to be labile?

Answer 27

V

Question 28

What role does vitamin K play in the Prothrombin group?

Answer 28

Carboxylates the factors to allow calcium binding

Question 29

Factor I deficiency will affect APTT and PT

Answer 29

True

Question 30

Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?

Answer 30

Cyclooxygenase

Question 31

Which statement regarding protein C is correct?

Answer 31

Activity is enhanced by Protein S

Question 32

Thrombocytopenia may be associated with

Answer 32

Hypersplenism

Question 33

The APTT is sensitive to a deficiency of which clotting factor?

Answer 33

None

Question 34

Which of the following factors will activate factor XI?

Answer 34

Hageman Factor

Question 35

Lumi-aggregation measures:

Answer 35

Aggregation and ATP release

Question 36

APTT is used to?

Answer 36

Both; Monitor heparin therapy and evaluate the common pathway

Question 37

Neurologic findings may be commonly associated with which of the following disorders?

Answer 37

TTP

Question 38

True of TTP and DIC:

Answer 38

APTT prolonged in DIC

Question 39

Which of the following tests is most likely to be abnormal in patients taking Aspirin?

Answer 39

Bleeding Time

Question 40

Platelet aggregation response for Glannzmann's Thrombasthenia

Answer 40

Normal to Ristocetin, Decreased to Epinephrine

Question 40

Thrombin-Trombomodulin complex is necessary for the activation of:

Answer 40

Protein C

Question 41

Scott syndrome will affect which of the following?

Answer 41

Secondary Hemostasis