Review Questions Flashcards by Clare Cariño

Major action of sodium chromoglycate

Mast cell stabilization

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Action of histamine

Stimulation of gastric secretion

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Resistant to penicillinase

Floxapen

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Inderal

Pure b-adrenergic receptor blocker

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Rifampicin

Tuberculosis

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Non-selective b1 blocker

Labetalol

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After meals

Post cibum

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Four times daily

Quater in die

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Every night

Quaque nocte

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Erythroped A

Effective against g+ cocci
Macrolide antibiotic
Increase GI motility
Used in pregnant women if needed

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Treatment of anaphylactic shock

Epinephrine

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Allopurinol

Agent which increases renal tubular reabsorption

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Not betamethasone side effect

Hypoglycemia

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Due to viral infection

Poliomyelitis
Chicken pox
Rabies
Herpes

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Atropine

Muscarinic antagonist

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Myocardial muscle tissue property to generate electrical

Automaticity

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Heart’s dominant pacemaker

SA node

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Adenosine indication

Supraventricular tachycardia

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Responsible for Buffering

Bicarbonates

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Respiratory acidosis is due to

CO2 retention

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Not a colloid solution

Ringer’s solution

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Adenosine P produces

facial flushing and dyspnea

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Shock signifies

Hypoperfusion

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Treatment of Shock

Airway control
Dopamine to support blood pressure
IV of crystalloid solution
Monitor Heart Rhythm

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Released by Bacterial Infection

Exotoxin

Amount of water in adult male

60%

Causes of Edema

Increase hydrostatic pressure Decrease oncotic pressure Capillary permeability

Patients prescribed non reversible monoamine oxidase inhibitor should be advised not to consume food containing tyramine because

Acute adrenergic crisis including severe hypertension

Concerning COX2 inhibitors, which is NOT true?

combination with non selective agents give more effective action

In the treatment of osteoporosis which of the following is NOT true?

hormone replacement therapy should be considered

First choice in acute gout

Indomethacin

Not a risk factor for osteoparalysis

Male gender

Early symptoms of aspirin poisoning

Ringing in the ears and blurred vision

Not true about infliximab

IL-I blocker

Disease-modifying drugs in rheumatoid arthritis

Gold preparations Hydroxychloroquine Methotrexate

A patient who is admitted through the ER with an initial diagnosis of arterial fibrillation

slow ventricular response using verapamil | consider anticoagulation with warfarin

True about surgical prophylaxis

Reduce the possibility of surgical site infection

Diagnosis of diabetes

oral glucose tolerance test | HBA1c

Goals of Diabetes Mellitus management

reduce onset of complications control symptoms of diabetes near normal glycemic control and HBA1c

Dosing insulin

initial dose 0.6u/kg/day split 2/3 am and 1/3 pm regular NPH ratio is 1:1 or 1:2 dose may need to be increased during acute illness

First line management to consider for obese with type 2 diabetes

Metformin

Non-aqueous pharmaceutical solutions

essences, collodions and elixirs

Drug exhibits dose dependent pharmaceutical therapeutic doses

Phenytoin

Propranolol is often prescribed with hydralazine to

reduce reflex tachycardia

ability of a liquid to dissolve

miscibility

True or false: | Lifestyle modification should not be enforced if an oral agent is to be started

False

in CHF management which is NOT correct

spironolatone should be avoided because of the great risk of hypokalemia Spironolactone is a potassium-sparing diuretic

NOT a primary literature

applied therapeutic and clinical use of drug

references to check compatibility of drugs in parenteral administration

handbook on injectable drugs | micromedic

When a CNS depressant is prescribed, which is NOT taken at the same time?

Diphenhydramine

A 4mg dose of lorazepam administered to an adult will act as

Hypnotic

drug of choice to control pain during acute myocardial infarction

morphine

Major contraindication to the use of an OTC sympathomimetic drug

Hypertension

Category C in FDA for drug used in pregnancy

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Patient advice on taking Rifampicin

may cause discoloration of urine

Correct method of parenteral administration of potassium

Slow IV injection

Route of administration that will provide rapid onset of action of morphine

Long-term administration of thiazide diuretics requires

K+ (to counteract Hypokalemia side effect)

What should be considered in drug therapy for hypertension?

Beta-blockers should be avoided in asthmatic patient

NOT used in theophylline toxicity management

Methylphenidate to reduce sedation

Use of ACEIs

Chronic Dry Cough

Treatment of Digoxin Toxicity

check Mg and K levels and correct if needed

The antimalarial to be avoided in glucose-6-phophate dehydrogenase deficiency

Primaquine

NOT characteristic of solution

the solvent and solute can be separated by filtration

Role of Carbidopa in treatment of Parkinsonism

Decrease dopamine in peripheral vessel

Role of B-blockers in angina

Beta blockers work by blocking the effect of adrenaline on the heart. This has two major beneficial effects in patients with angina: Slowing of the heart rate, in particular during periods of exercise or stress. Reducing the force of heart muscle contraction.

When drug is absorbed through GIT then go to liver and excreted, this process is called

First pass

All have anti-inflammatory and analgesic effect except

Sevredol (morphine) - opioid analgesic

need filtration before IV infusion

mannitol

Azaleic acid used in

acne

Hormone secreted from posterior pituitary gland

oxytocin

To increase duration of lidocaine in anaesthesia

Epinephrine

Drug absorption depend on

Dosage form

Monitoring for dose in elderly patient

decrease in kidney excretion | decrease in liver enzymes function

Metallic taste

Captopril | Metronidazole

Optimal size for ophthalmic drops

< 10ug

Amphetamine is used in

detect awareness in the brain of children

expiry November 2006

use until November 31 2006

Mechanism of action of Buspirone

5HT agonist decrease serotonin increase dopamine and norepinephrine

Nitroglycerine

Coronary vasodilation

Omeprazole

decrease gastric acid secretion

Aldosterone antagonist effect

Spironolactone

Change of color of urine to red

Nitrofurantoin | Rifampicin

Patient taking Gentamicin for a long time needs which monitoring test

Serum concentration level

Antiarrhythmic Class Ia

Quinidine

Antiarrhythmic Class II produce its action through

suppress phase 4 depolarization

Antiarrhythmic Class Ib produce its action through

shorten phase 3 repolarization

Chiral molecule mean

optical activity

Lovastatin produce action through

HMG-co reductase inhibitor

Lisopril, Zinopril and Zestril are brand names of

Lisinopril

am is abbreviation of

ante meridiem / at morning

gtt od bid

gutta oculus dexter bis in die | one drop in the right eye twice a day

Tegretol (Carbamazepine)

Status epilepticus, Seizures

Streptokinase

Pulmonary emboli

``` All of the ff are antifungal except: Nystatin Ketoconazole Amphotericin Gamciclovir ```

Gamciclovir (antivirus)

Ceftazidime

third-generation cephalosporin

Bambuterol

Asthma

Traveler's diarrhea

Ciprofloxacin

Cause of traveler's diarrhea

E.coli

Use of Diazepam

Anxiety

Solid to be reduced in size before dissolving is called

Disintegration

Benzodiazepine mechanism

binding δ subunit of GABAA receptor

Vinca alkaloids produce anticancer drugs

vincristine vinblastine vindesine

Warfarin monitoring therapy by

INR (international normalized ratio)

In ovulation phase, which hormone is predominant

Luteinizing hormone

Vecuronium is used as

Skeletal muscle relaxant

Most common process of sterilization

Moist Heat

Which needs serum level monitoring with Quinidine

Digoxin

Side effect of epinephrine

Nausea & Vomiting

Drug used for treatment of Migraine and Hypertension

Clonidine

Can't be used as monotherapy in mild HTN

Hydralazine

Which has cathartic side effect

Magnesium sulfate

Normal water can be used in

External preparation

Ecothiopate mechanism is through

Make complex with acetylcholinesterase and inhibit its action

Tetracaine is used as

Spinal Anesthesia

Half life for first order kinetic

0.693k

Adsorption are affected by the ff except: a) Physical reaction b) Chemical reaction c) Irreversible d) Reversible e) B & C

Chemical reaction | Irreversible

Charcoal produce its action through

Adsorption

Digoxin used in treatment of CHF has

+VE inotropic effect

PPM means

part per million OR million part

All are causes of secondary HTN except: a) phyochromocytoma b) cholinergic agent c) sodium intake

b) cholinergic agent

Patient with CHF take digoxin and hydrochlorothiazide with X-ray indicating arthritis which is the best medication

Prednisolone

If a drug has the same active ingredient like other drug but not contain the same inactive ingredient this means?

Pharmaceutical equivalent

Concentration of a drug is 7.5mg in teaspoonful. What will be the concentration in 150ml?

225mg

Which of the ff is not a colloid: a) krebs solution b) albumin 2% c) dextran d) beta starch e) albumin 20%

Krebs solution

Sildenafil is found in

Viagra

Alteplase is used as

Fibrinolytic (thrombolytic)

Salbutamol is used as

Bronchodilator

Podocodeine is used in

Dry cough

Which of the ff is NOT used in emergency HTN: a) furosemide b) pindolol c) labetalol

Pindolol

Doxorubicin side effect

Cardiac toxicity

Which of the ff is NOT used in treatment of asthma: a) b2 agonist b) b2 antagonist

b2 antagonist

Which is an alkylating agent and anticancer

Cyclophosphamide

very small molecule (1 part) soluble in 10,000 part of water

slightly soluble

Benzoil is not soluble in H2O but soluble in Benzene in 25C

Non polar

A member of phenothiazines group

Prochlorperazine - antipsychotic

Primidone is a prodrug for

Antiepileptic Phenobarbital PEMA (Phenylethylmalonamide)

Daily recommended dose for folic acid

400-500mcg

Daily recommended dose for vitamin C in male

90mg/day

Daily recommended dose for vitamin C in female

50mg/day

Maximum daily dose for paracetamol is

4000mg

Ergot alkaloids is used as treatment for

Migraine

Buffering agent used in ophthalmic drops to

decrease irritation to eye and increase stability

Picosulphate is used as

Laxative

Digoxin toxicity increase with

Renal failure

All of the following are side effect of oral contraceptive except: a) hypertension b) weight gain c) hyperglycemia d) dizziness e) constipation

Constipation

Which narcotic is not used today

Heroin

Drug stored in the body is found where

Fat

Which dosage form is famous

solution, ointment and gel

In case of hepatic or renal failure which muscle relaxant is recommended

Atracurium

Heparin can be monitored through

aPTT - activated Partial Thromboplastin Time | time taken by plasma to clot

Enoxoparin is administered

S.C.

If drug protein binding increases or decreases, what will be affected

increase of half-life | decrease of half-life

3rd generation cephalosporin has

G+ve, G-ve

Solubility is enhanced through

reduce particle size | increase surface area

determination analysis of solution depend on

nature of solute | type of solution

When use liquid or ointment to dissolve the solid, it is called

Levigation

Phenytoin act on

GABA receptor

NSAIDs produce action through

decrease prostaglandin synthesis

Which of the ff is NOT a characteristic of Theophylline: a) relaxation of bronchial smooth muscle b) increase cardiac contractility c) nausea, abdominal disturbance d) convulsion e) sedation

Sedation

What is the drug of choice in the treatment of bronchospasm or asthma?

Salbutamol / Albuterol

A drug that causes depression

Reserpine

Prevoc is a trade name used as

antiplatelet - ticlopidine

How many kg is a pound

0.454kg

Sustained release dosage form is used to

increase half-life

Drug after metabolized in liver will become

Polar

a large initial dose of a substance or series of such doses given to rapidly achieve a therapeutic concentration in the body

Loading dose

Half life of a drug is 7 days, how can it be taken?

every week

Diltiazem is classified as

calcium-channel blocker

B-carotene is a precursor of

retinol

electrical property which produce impulses is called

automaticity

infusion of hypotonic solution in blood cause

hemolysis

denaturation will happen in body for which compounds?

proteins

major metabolism process in GIT is

Hydrolysis

Dosage form of nitroglycerin when used in malignant hypertension

Infusion

Drug induced lupus-like syndrome is associated with which antihypertensive

Hydralazine

Hypothyroidism causes

Weight gain

ACE I mechanism of action as antihypertension?

Inhibition of converting angiotensin I to angiotensin II

First pass effect increases what

Rate of absorption | Biotransformation

Metal used in rheumatoid arthritis

Gold

Low density lipoprotein (LDL) act as

carrier cholesterol in plasma

True solutions another name is

Homogenous

About ophthalmic preparation as single dose which is false: a) sterile b) purified c) should contain preservative

should contain preservative

Most drugs are: a) weak electrolyte b) non electrolyte c) non ionic d) strong electrolyte e) b+c

Weak electrolytes

Antipseudomonas drug

Vancomycin

Digoxin differ from digitoxin how

excreted unchanged in urine

In digoxin induced arrhythmia, what is NOT recommended? a) stop digoxin administration b) phenytoin administration c) give lidocaine d) give digoxin immune fab e) electrical cardio

Electrical Cardio

Which is NOT asthma property: a) bronchodilator b) bronchospasm c) increase mucous secretion d) chest pain

Bronchodilator

Hormone NOT excreted from adrenal cortex a) Growth hormone b) Primary product c) Mineral corticoids d) Glucocorticoids

Growth hormone

All of the following are side effects of methotrexate except: a) bone marrow depression b) alopecia c) nausea and vomiting d) drive sex gland

Drive Sex Gland

MOA of Antipsychotic drug

Dopamine Receptor Inactivation

ACE inhibitors are contraindicated in:

Bilateral Renal Artery Stenosi

Cardioglycosidic effect

+ve, inotropic

All factors affect on Distribution of drug except: a) tissue solubility b) protein binding c) molecular weight of drug d) type enzyme response of metabolism

type enzyme response of metabolism

All factors affect on renal clearance except: a) age b) sex c) both d) disease state

Sex

Ointment is used for: a) carrier of drug b) emollient c) a & b d) increase absorption e) increase distribution

Carrier of Drug | Emollient

In hypodynamic shock treatment, we use: a) dopamine b) nicotine c) aspirin

Dopamine

Acyclovir is used for

Herpes Simplex

A lady taking chronic warfarin, which is not true: a) avoid aspirin containing preparation b) avoid doubling dose from herself c) balanced food with green leaves to avoid thrombosis d) if she is pregnant, monitor INR to avoid DVT e) take care about nasal bleeding

If she is pregnant, monitor INR to avoid DVT

Which of the ff has least sedative action? a) diazepam b) estazolam c) triazolam d) temazepam

Diazepam

Drug that has Spasmolytic action

Amphetamine

Desmopressin is used in

Nocturnal enuresis & | Diabetes insipidus

Pentoxifylline is used as

Peripheral Vasodilator

Normal water is used for

External Preparation

Ceftazidime

3rd generation Cephalosporin

About Aminoglycoside, which is NOT true? a) has gram + activity b) less toxicity c) narrow therapeutic d) compatible with other drug e) usually IV or IM

Less toxicity

About Norepinephrine, which is NOT true? a) increase BP b) vasoconstrictive c) used in cardiogenic shock d) effective orally e) SC

effective orally

Pharmacokinetic Constant

Zero order

Which of the ff is NOT prednisolone side effect? a) cataract b) hypoglycemia c) skeletal muscle weakness d) sodium retention e) lowered resistance to infections

Hypoglycemia

When considering drug therapy for hypertension, which is true? a) combination of drugs always preferred b) hydralazine is first line therapy in young hypertension c) furosemide should be administered before meal to improve absorption d) b-blockers should be avoided in asthmatic patient e) ACEis are recommended in pregnant women

B-blockers should be avoided in asthmatic patient

Solutions are better than solid dosage form because of

Faster action

One of the ff is NOT used to cover bitter taste a) film coat b) enteric coat c) grinding of tablet

Grinding of Tablet

A tricyclic antidepressant that is a tertiary amine

Amitriptyline

Antihypertensive that is used in pregnancy

Alpha Methyldopa

Drug used for peptic ulcer

Losec (Omeprazole)

Drug infusion rate is 2mg/kg/hr, infused for 12hours, for 70kg patient, what is the total dose?

2x70x12 = 1680mg

GMP means

Good Manufacturing Practice

According to Sterile method, what is false about filtration?

able to filter viscous substance

When you know the preservative used with antibiotic is not suitable, what should be done?

Use another that is suitable

Diltiazem, Nifedipine and Felodipine act by

block Ca to intracellular & increase metabolism from storage site

All of this affect rate of absorption except: a) chemical stability b) PH c) protein binding d) a & b e) b & c

Protein binding

Alteplase and Streptokinase used in

Pulmonary Emboli

Cholestyramine Resin act by

Anion exchange

Concentration of ionized & unionized calculated by

Henderson Hasselbalch equation

Light sensitive drug should be stored in

Amber glass

Electromagnetic rays

Gamma rays | X-rays

Isoproterenol (isoprenaline) is categorized as

Adrenergic agonist medication

Coal tar uses

Psoriasis | Dandruff

Most common reaction catalysed by cytochrome P450

Monooxygenase

Most common phase I reaction

Oxidation

Which of the ff is NOT used in Peptic ulcer: a) tetracycline b) itraconazole c) metronidazole d) bismuth subsalicylate e) clarithromycin

Itraconazole

Which of the ff act as Alpha-1 blocker: a) hydralazine b) terazosin c) propranolol d) captopril e) clonidine

Terazosin

Comparison between sterile water and water for injection

Pyrogen-free | Isotonic

Quinidine has similar action with

Procainamide

Which of the ff drugs has side effect of lupus like syndrome: a) lidocaine b) minoxidil c) procainamide d) hydrochlorothiazide

Procainamide

Over dose of digoxin, we use

Antidote FAB fragment

Ampicillin has similar action with

Cephalexin

Cephalosporin act as:

Inhibitors of cell wall synthesis

antibiotic used as anti-pseudomonas aeruginosa

meropenem

antipseudomonal antibiotic

Piperacillin Carbenicillin Ticarcillin

Auxiliary label are written on box contain Co-trimoxazole, all are true except: a) shake the bottle before use b) suspension c) freezing of drug d) keep out of reach of children

Freezing of Drug

Ipratropium bromide MOA

anti-muscarinic bronchodilator

Keep in cool place means

10-20C

Amphetamine act as:

Indirect-acting adrenergic agonist

Increasing the plasma HDL level

Reduces risk of atherosclerosis

Warfarin acts as

Anticoagulant

Cyclophosphamide side effects are: a) blurred vision b) vomiting, alopecia c) bone marrow depression d) a & b e) b & c

b & c Vomiting, alopecia Bone marrow depression

Drug used in open angle glaucoma

Pilocarpine

All ACEi are prodrug except

Captopril

Ophthalmic preparation preferred to be taken

Solution > Ointment > Suspension

Digoxin toxicity precipitated by

Hypokalemia

A drug that has anti-inflammatory effect

Ibuprofen

Digitoxin effect in ECG

Prolong PR

Instrument to use in relative bioequivalent compared between standard drug and test drug

AUC (Area Under the Curve)

Cephalexin

1st generation cephalosporin

After myocardial infarction, we use:

Anti-platelet such as Aspirin

Omeprazole is used for

Peptic ulcer

Alpha 2 agonist act by

Decrease Blood Pressure

Equation that determine acid and base degree is

Bronsted equation

Isoniazid is used in

Tuberculosis

Buspirone MOA

Serotonin (5HT2a) receptor

All these cases occur with thiazides except: a) hypernatremia b) hyperglycemia c) hypokalemia d) hyperuricemia e) hyponatremia

Hypernatremia | *Thiazides prevent reabsorption of Na

Drug of choice for Myxedema (Hypothyroidism)

Thyroxine sodium

Vitamin A daily dose for correction of the deficiency

30,000-50,000IU/day

Vitamin A daily dose for therapy

100,000-200,000IU/day

All these cases occur with Thiazides except: a) hypercalcemia b) hypoglycemia c) hypokalemia d) hyperuricemia e) hyponatremia

Hypoglycemia

Zidovudine is used for

HIV

Bisacodyl is used as

Laxative

POM means

prescription only medicine

Concentration of drug on expiry date

from 90%-110%

Surfactant not used orally

sodium lauryl sulphate

drug transfer through the cell membrane is

Passive diffusion

Calcipotriol is indicated for

Psoriasis

Drug that makes water retention

Indomethazine

Nitroglycerin effect

Vasodilation of Coronary Artery

Antipsychotic drugs act as

Dopaminergic antagonist

Vitamin K is antagonist of

Warfarin

Protamine sulphate is antidote of

Heparin

Promethazine is used as

Antihistaminic (pruritis, cough, antiemetic)

Prazosin MOA

Alpha 1 blocker

Esmolol MOA

Short-acting b-blocker used in emergency acute arrhythmia as IV administration

Which of the ff has no effect in drug response? a) nutrition b) genetic c) mental status d) age e) disease

Mental Status

Cyclizine is used in

Nausea and Vomiting

Which of the ff is not side effect of propantheline: a) blurred vision b) dry mouth c) constipation d) bronchospasm e) urinary retention

Bronchospasm

Probenecid increases the concentration of penicillin through

Decrease renal excretion

One of the ff is NOT a toxic effect of methyldopa: a) sedation b) drug fever c) gangrene d) anemia e) hepatitis

Gangrene

Patient taking cisplatin should be taken with

Granisetron (anti emetic)

Purified water cannot be used in

Ophthalmic preparation | IV solution

Ascorbic acid is

Vitamin C

MOA of Tricyclic antidepressant

Serotonin & NE reuptake inhibitor

Active immunity can be conferred by

Vaccine

MOA of Echothiophate

Form stable complex with cholinesterase enzyme Indirect-acting cholinergic agonists Anticholinesterases - irreversible

Stat means

Immediately

Volume of blood cleared through kidney

Renal clearance

Ventamax is a

Bronchodilator

Diltiazem is NOT used in which of the ff: a) heart failure b) angina pectoris c) hypertension d) SA node block e) headache

Heart failure

Drug used in diarrhea & constipation

Polycarbophil | Pectin

Alpha blocker side effect

Postural hypotension

Dose of Cefixime

400mg

Dose of Aspirin as antiplatelet

80mg

Co-trimethoxazole percentage of trimethoprim to sulfamethoxazole

1:5

Diazepam overdose treatment

Flumazenil

Theophylline side effect is

Insomnia

Dipivefrin is for

Glaucoma

Which of the ff does NOT occur in digitalis toxicity: a) hypokalemia b) hypomagnesemia c) hypocalcemia d) hypothyroidism e) impaired kidney function

Hypocalcemia

Verapamil is categorized as

Class IV Antiarrhythmic

Patient who is allergic to penicillins use

Erythromycin

Tetracaine is used for

Spinal Anaesthesia

Sterility through 0.22m filter does NOT remove

Virus

Not used clinically anymore: a) heroin b) morphine c) codeine d) oxycodone

Heroin

Drug increases action of Morphine

Amiodarone

Side effect of class 2 antiarrhythmic

Bronchospasm

In CHF, we use digoxin to

Increase Myocardiac Contraction

Least sedating: a) diazepam b) chlordiazepoxide c) probamate d) oxazepam e) buspirone

Buspirone

Drug NOT decreases LDL a) simvastatin b) clofibrate c) nicotinamide d) propecol

nicotinamide

Raloxifene is a what

Selective estrogen modulator contraindicated in DVT patient

Promethazine is used for

Antihistamine

Which of the ff is not used in diagnosis of acute MI a) albumin b) signs and symptoms c) troponin d) scurvy e) a & d

Albumin | Scurvy

Cushing syndrome is caused by

A pituitary gland tumor (pituitary adenoma). A noncancerous (benign) tumor of the pituitary gland, located at the base of the brain, secretes an excess amount of ACTH, which in turn stimulates the adrenal glands to make more cortisol.

q.d.s means

quater die sumendum | take 4 times daily

Vitamin A to be avoided in

Pregnancy

Which is NOT a effect of theophylline: a) peripheral vasoconstriction b) cardiac stimulation c) diuresis d) relaxation of stomach muscles

Peripheral Vasoconstriction

Not expected with inhaled smoke of Cannabis a) increase pulse rate b) anorexia c) preseptal changes d) vascular changes of the eye

anorexia

Na picosulfate is used as

Laxative

Dopamine is used in cardiac shock and acts by

selectively dilating renal and mesenteric vessels

Verapamil can increase effect of theophylline, carbamazepine and digoxin by

acting as a liver enzyme inhibitor

used in treatment of Parkinsonism

Dopamine

Aspartame is used as a

Sweetener

True or False: | HRT should be done in ALL postmenopausal women

False

Properties of catecholamine

rapid metabolism by COMT and MAO

Antihypertensive drug that acts as alpha 1 blocker in artery and vein

Terazosin

ACEi & ARBs are contraindicated in

Renal artery stenosis patients

Cycloserine is used in TB for how long?

18-24 months

Natural water can be used in

External preparation

Ideal volume of eye solution

<10ug

Dipivefrine is

Epinephrine analogue used in open-angle glaucoma

Doxorubicin is used as

antiviral for herpes simplex

When a pharmacy owner gives direction to an employee in his pharmacy to monitor policies and regulation, it is a

consultative

All are action of caffeine except: a) CNS stimulant b) skeletal muscle relaxant c) diuretics d) cardiac stimulant

skeletal muscle relaxant

Nitroglycerin side effect

tachycardia

Propranolol is a

non-selective b-blocker

Which of the ff drug causes tachycardia: a) propranolol b) atenolol c) hydralazine

hydralazine

Enkephalin / Encephalin is a peptide that has

similar action to morphine

Pentoxifylline is used as

Vasodilator

main site of excretion of the drug in the body

kidney

clofibrate act by

decreasing lipoprotein

water used for reconstitution of large dose of parenteral is

sterile water for injection

All of the ff are side effect of hydrocortisone except: a) sodium retention b) glucose intolerance c) arthritis d) osteoporosis

arthrisis

Reserpine side effect

Depression

pH is used to

determine acidity

enzyme cytochrome P450 was discovered by

Axelrod and Brodie

Bioavailability means the drug reached

blood circulation

Which of the ff drugs is a systemic amoebicide? a) diloxanide furoate b) pyrimethamine c) emetine d) sodium stibogluconate

emetine

Drug of choice for treatment of all forms of Schistosomiasis

Praziquantel

Which of the ff drugs can be used for the treatment of influenza A infection? a) zidovudine b) amantadine c) ribavirin d) vidarabine

amantadine

Which of the ff drug is used in the treatment of Leishmaniasis? a) pyrimethamine b) diloxanide c) sodium stibogluconate d) emetine

sodium stibogluconate

All of the ff preparations contain alcohol except: a) syrup simplex b) aromatic ammonia spirit c) terpin hydrate elixir d) belladonna tincture

syrup simplex

Which of the ff solutions is used as an astringent? a) strong iodine solution b) aluminium acetate topical solution c) acetic acid d) benzalkonium chloride solution

aluminium acetate topical solution

Extrapyramidal adverse effects are caused by the blocking of

Dopamine receptors in the brain

Steven Johnson syndrome is a severe

Skin reaction

Which of the ff are side effects of phenytoin treatment? a) acne b) hirsutism c) gingival hyperplasia d) all of the above

all acne hirsutism gingival hyperplasia

All factors affect on distribution of drug except: a) partition coefficient b) rate of blood flow to tissue c) pH

pH - absorption

Which of the ff is NOT betamethasone side effect? a) hypoglycemia b) skeletal muscle weakness c) sodium retention d) lowered resistance to infections

hypoglycemia

Which of the ff are causes of edema? a) increase hydrostatic pressure b) decrease oncotic pressure c) increase capillary permeability d) all of the above

All increase hydrostatic pressure decrease oncotic pressure increase capillary permeability

All these are side effects of Chloramphenicol except: a) irreversible aplastic anemia b) optic neuritis c) peripheral neuritis d) iron deficiency anemia

iron deficiency anemia

Ticlopidine is used as

Antiplatelet

All these drugs are fibrinolytic except: a) dipyridamole b) streptokinase c) urokinase d) none

dipyridamole

All these drugs cause anti-metabolic effect except: a) methotrexate b) fluorouracil c) cytarabine d) cyclophosphamide

cyclophosphamide

All of these drugs can be used for Parkinsonism except: a) selegiline HCl b) carbidopa c) pergolide d) nedocromil sodium

nedocromil sodium

cardiac arrest could be managed by the ff except: a) ephedrine b) lidocaine c) propranolol d) normal saline

propranolol

Insulin which can be given as IV is

regular type

All these drugs are antibacterial except: a) mbine b) lomefloxacin c) cefoperazone

zalcitabine

All these are natural estrogens except: a) mestranol b) oestrone c) oestriol d) oestradiol

mestranol

Which one of the ff has vasodilator effect: a) nicotine b) cholestyramine c) urokinase d) vitamin D

nicotine

One of the ff is NOT from Quinolone group: a) nalidixic acid b) quinine c) enoxacin d) norfloxacin

quinine

One of the ff is NOT for epilepsy: a) clonazepam b) phenytoin c) primidone d) imipramine

imipramine

Sumatriptan is used for

Treatment of Migraine

All of the ff are for prophylaxis of asthma except: a) ketotifen b) nedocromil sodium c) sodium cromoglycate d) salbutamol

salbutamol

All of the ff is NSAH (non-sedating antihistamine) except: a) loratidine b) cetirizine c) astemizole d) azotodin

azotodin - no such drug

All of the ff are controlled drugs except: a) Rivotril b) Epanutin c) Stesolid d) Diazepam

Epanutin

Which one of the symptoms does not occur with morphine: a) diarrhea b) respiratory depression c) constipation d) vomiting

diarrhea

Which one of these drugs is NOT used for acute pain: a) naproxen b) colchicine c) codeine d) prednisolone

prednisolone

Hepatitis vaccine dose is

3 times a year

One of the ff is given once daily: a) amorphous insulin b) protamine zinc insulin c) neutral insulin d) regular insulin

Protamine zinc insulin

Dobutamine is given IV because

It is not soluble in gastric pH

Amiloride and Triamterene causes

Hyperkalemia

Cefaclor is a

2nd generation cephalosporin

Which aminoglycoside antibiotic can be taken orally? a) gentamycin b) neomycin c) amikacin d) tobramycin

Neomycin

infusion of hypertonic solution in blood causes

shrinking of blood cells

Isoproterenol is a

B agonist

Enkephalins are peptides that

exert actions resembling those of opiates

How to measure severity of immunodeficiency in HIV

CD4 count

The ethical principle of veracity requires that:

we act with honesty, without deception

A patient purchasing sublingual nitroglycerin tablets should be told to store the medication:

in an Amber glass bottle with a metal cap

Nonmaleficence

avoid, remove or prevent harm from people

Hydroxyurea is a

antineoplastic drug

Which of the ff is taken orally: a) estrogen b) estrogen gluconate c) estrogen maleate d) all of the above

estrogen gluconate

Responsibility of phamacist in hospital is

deal with drug interaction

plasma concentration of drug in all body is

Therapeutic volume

What is domperidone

Anti-emetic without CNS effect

Prescription of narcotics in the pharmacy should be kept for how many years

5 years

Pka for normal water in room temp

Drug that makes urine red other than rifampicin

Phenazopyridine

Syncope (fainting) may occur with 1st dose of which drug

Prazosin

Action of digoxin can be reduced with

Hyperthyroidism

Main cause of digitalis toxicity is

Renal failure

Digitalis arrhythmia can be treated with

Lidocaine

Used in Ventricular Arrhythmia with Heart block

Procainamide

Which one is antiarrhythmic class 1A: a) phenytoin b) disopyramide c) propranolol d) verapamil e) propafenone

Disopyramide

Anticancer derived from venca is

Cisplatin

Used for trigeminal neuralgia

Tegretol (Carbamazepine)

Solution contain 9ppm of NaCl, concentration of the compound in the solution is

0.009

Process require CYP450

Oxidation

About steady state concentration during IV administration

Directly proportional to infusion rate | Inversely proportional to total body clearance

Which of the ff decrease gastric emptying rate: a) metoclopramide b) atropine c) hypothyroidism d) a & b e) b & c

Atropine | Hypothyroidism

Side effect of Quinidine

Cinchonism

About digitoxin, which is false: a) oral bioavailability 100% b) protein binding 95% c) half life is 7 days d) mainly hepatic metabolism by microsomal

Oral bioavailability 100%

Volatile substance given by inhalation

Halothane

To compare between 2 drugs, use:

Pharmacodynamic parameter

In tolerance

Patient need more dose to obtain the same effect

Causes of hypothyroidism

Iodine deficiency | Low hypothalamus and Pituitary hormones

Phenytoin uses

Anti convulsant Treatment of irregular heart beat Treatment of painful nerve conduction

Arrhythmia is due to:

Dysfunction to generate heart pulse or conduction of it

Guanethidin side effects

Prevent ejaculation Orthostatic hypotension Diarrhea

Not fom WBC

Reticulocyte

Minoxidil MOA

dilates arteries only

Mizolastine used as

non-sedating antihistaminic

All these drugs are antimetabolite except

Cisplatin | Cyclophosphamide

Digitoxin, what is not true

Taken only orally

Captopril and Enalapril do all the ff except: a) increase renin conc in blood b) inhibit an enzyme c) competitively blocks angiotensin at its receptor d) raises the blood potassium concentration

competitively blocks angiotensin at its receptor

Various opiates may be used as all of the ff except: a) analgesics b) anti-inflammatories c) antidiarrheals d) aids to anesthesia e) antitussive

anti-inflammatories

Which of the ff action is not seen with sympathomimetics? a) pupil constriction b) increased heart rate c) bronchodilation d) systemic blood vessel constriction

pupil constriction

Which of the ff beta-adrenergic agents is not short acting? a) pirbuterol b) salmeterol c) terbutaline d) albuterol e) none of the above

Salmeterol

Which of the ff drugs is not a tricyclic antidepressants? a) trimipramine b) maprotiline c) nortyptiline

Maprotiline

Most common disintegrator

Starch

found in vitamin b12

Cobalt

Gums are used in tabletting as

binding agents

Cyclosporine is used for

prevention of transplant rejection

Ultra-short acting barbiturates are used primarily as

pre-anesthetic agents

for a 4 year old child, the maximum daily dose of paracetamol is

Which one of the ff cannot be dispensed without prescription: a) ibuprofen b) doxycycline c) aspirin d) bisacodyl

Doxycycline

aim in the management of uncomplicated hypertension

85/130

solid dosage forms are better than solution dosage form because:

accurate dose easy to handle more stable

Tolerance is a problem when using nitroglycerin, which of the ff is true: a) tolerance doesn't occur in young patient b) over 50 years patient doesn't develop tolerance d) dosing schedule may affect tolerance d) isosorbide dinitrate doesn't develop tolerance

Dosing schedule may affect tolerance

electromagnetic waves in increase ranking in air

alpha, beta, gamma

Grey man syndrome

Amiodarone

Indapamide is used in

Pulmonary edema | Essential hypertension

One of the ff is not related to heparin: a) prevent blood clotting b) decrease antithrombin time c) prevent formation of factor VII d) used in pulmonary emboli

prevent formation of factor VII

Hypertonic solutins can be adjusted by

make dilution by adding more solvent

Enterohepatic recycling depend on all of the ff except: a) dosage form of the drug b) extent of drug passed in feces c) extent of drug absorption from stomach d) gallbladder state

extent of drug passed in feces

drugs that show most multidrug resistance

antibiotics | anticancer

The ff liquids are least likely to be miscible: a) polar + polar b) nonpolar + polar c) nonpolar + nonpolar d) all of the above will be miscible e) b and c

nonpolar + polar

The following properties are similar for both solutions and suspensions: A. The components of both solutions and suspensions can be separated from each other by physical processes. B. Solutions and suspensions are composed of two or more components. C. Solute in the solutions and suspensions settle out over a period of time. D. Both A and B E. Both Band C

A. The components of both solutions and suspensions can be separated from each other by physical processes. B. Solutions and suspensions are composed of two or more components.

Side effects of albuterol include which of the ff? a) bradycardia b) tachycardia c) convulsion d) hypotension e) alopecia

Tachycardia

Which of the following side effects is associated with the use of norepinephrine: A. Nausea and vomiting. B. Ischemic damage due to vasoconstriction and tissue hypoxia. C. Hypoglycemia due to increase insulin release. D. Skin rashes. E. Headache and constipation.

Ischemic damage due to vasoconstriction and tissue hypoxia.

pharmacological property of amphetamine is

causes release of stored norepinephrine

First dose phenomenon associated with prazosin

marked postural hypotension 30 to 90 mins following initial dose

All of the ff are diazoxide side effects except: a) tachycardia b) diuresis c) hyperglycemia d) hyperuricemia e) hypotension

diuresis

Causes hypotension due to blockage of efferent limb baroreceptor reflex

Bretylium

Thiopental is a

short acting barbiturates

Which of the ff is not macrolide antibiotic? a) erythromycin b) spiramycin c) chloramphenicol d) clarithromycin e) azithromycin

chloramphenicol

Digoxin action except: a) +ve inotropic b) shorten refractory period in atrial and ventricular myocardial c) increase conduction velocity in AV node d) contraction of myocardial muscle

increase conduction velocity in AV node

Milrinone has the ff except: a) +ve inotropic b) vasodilator c) increase Ca intercellular d) phosphodiesterase inhibitor e) potentiate the effect of cAMP

increase Ca intercellular

To decrease radiation exposure, all are correct except: a) increase the distance from radiation source b) out from the place of radiation c) put shelves e) decrease the activity of radiation person

decrease the activity of radiation person

how many gm of water ad to 5% KCl solution to make 100g of solution w/w?

Causes hypertensive crisis if withdrawn suddenly

Clonidine

Which one is not effect of nitroglycerin: a) vasodilation b) relax of biliary muscle c) slow heart rate d) taken sublingually e) decrease blood pressure

slow heart rate

Drugs have different crystal structures so different in

polymorphism

Which of these have intrinsic sympathomimetics effect: a) labetalol b) timolol c) nadolol d) pindolol e) propranolol

pindolol

protect from light in usp means

light resistant container

daily intake of vitamin A for adult female is

700mcg

Most potent anti-inflammatory corticosteroid systemically is

dexamethasone

Suspension eye drop differ than ophthalmic solution in:

less commonly used | used for insoluble drugs

Cushing-like syndrome is due to

Adrenal hyperplasia

Morphine causes respiratory depression by

depression of respiratory center in brain

Calcium-channel blockers mode of action

Decrease the inward calcium to cells

Phenylephrine a) used in nasal decongestant b) in high doses stimulate b adrenergic receptor c) not substrate for catecholamine or methyltransferase d) all of the above e) both a and c

both a and c used in nasal decongestant not substrate for catecholamine or methyltransferase

Enzyme kinetics law

Michaelis-menten law

Amphetamine pharmacological action

indirect acting adrenergic agonist

most described dosage solid form

tablet

has 5-HT antagonist and H1 antihistamine effects

Cyproheptadine

Dobutamine is used as

in cardiac surgery

Controlled released drug delivery depends on:

ready programmed & no influence of the body fluid

All of these are anticholinergic except: a) atropine sulphate b) hydrotropine c) mebeverine d) ipratropium bromide e) tiotropium bromide

mebeverine

``` all these drugs used in amoebic dysentery except: metronidazole diloxanide gentamycin tetracycline ```

gentamycin

Terbutaline is used as

Antiasthmatic

Freeze drying is done by

Sublimation

Converting big fragments into small fragments is

Reduction

p.r.

for the rectum (per rectum)

qqh means

quatra quaque hora

Bretylium class 3 anti arrhythmic is

adrenergic neuronal blocking agent | K channel blocker

Amantadine

increases dopamine release and blocks dopamine reuptake

Diphtheria is an upper respiratory tract illness caused by

Corynebacterium diphtheria

Indamide use

Sulfonyl urea

Drug used in absence seizure

Ethosuximide

Angiotec is the trade name of

Enalapril

The parameter describing dissociation in solution

pka

reserpine mechanism

deplete catecholamines from sympathetic nerve endings

MAOi work through

increase availability of monoamine neurotransmitter

main side effect of nitrites

headache

volatile liquid drug given as inhaler

amyl nitrite

phentolamine (regitine)

reversible nonselective alpha-adrenergic antagonist

ACE mechanism is

converting Ag1 to vasoconstrictor Ag2

Differences between captopril and other ACE inhibitors

differ in potency (captopril is more potent)

diuretic which is used with Captopril

Thiazide

Effects of Captopril

inhibits the conversion of Ag1 to Ag2 effective hypotensive when others are contraindicated has a valuable role in heart failure

ACE inhibitors are used in the treatment of

Hypertension

B-blocker is used for

Essential Hypertension

Which of the ff is not cardio specific B-blocker

Labetalol

One of these is not like the others: a) timolol : non-selective B-blocker b) acebutolol : selective B-blocker c) labetalol : non-selective B-blocker d) betaxolol : non-selective B-blocker

Betaxolol is a selective B1 receptor blocker

All of the ff are B2 antagonists except: a) salbutamol b) metoprolol c) nadolol d) atenolol

Salbutamol - B2 agonist

B1 agonist cause

increase in oxygen consumption increasing ectopic effect increasing inotropic effect

Quinidine sulphate is

anti-arrhythmic agent

Procainamide is like

Quinidine

Which one is not Ca channel blocker? a) Verapamil b) Diltiazem c) Amlodipine d) Cinnarizine

Cinnarizine

Thiabendazole is one of the Thiazide diuretics

False

Potassium supplement therapy must not be given with

Triamterene

Nitroprusside Na is

Potent Vasodilator

All these drugs are anti-cholinergic except: a) ipratropium b) atropine sulphate c) benztropine mesylate d) dobutamine

Dobutamine - sympathomimetic drug

Epinephrine has alpha and beta agonist activity so it causes

Increasing in heart rate and increasing in blood pressure

Dobutamine is given IV because

it is not stable in gastric acid of stomach

Hydralazine is used as antihypertensive through

Vasodilation

Which of these has no vasodilator effect? a) methyldopa b) hydralazine c) enalapril d) prazosin

Methyldopa

Which one has vasodilator effect? a) nicotinic acid b) nalidixic acid c) vitamin a d) urokinase

nicotinic acid

Zinnat contains

Cefuroxime

Nitrofurantoin is indicated for

Urinary Tract Infection (UTI)

Ipeca is emetic agent which induces emesis through

Stimulation of the stomach | Stimulation of the CTZ (Chemoreceptor Trigger Zone)

Theophylline is a

Bronchodilator

Theophylline dose in children

increased metabolism and dose must be increased

modern method in treating asthma

long acting bronchodilator + corticosteroid

Tx of anaphylactic reaction is indicated in the ff except: a) hydrocortisone b) cimetidine c) human albumin d) epinephrine

cimetidine

introduction of emesis is not indicated in the ff except: a) caustic substance ingestion b) CNS c) seizures d) paracetamol poisoning

paracetamol poisoning

All of these are anions except: a) phosphate b) acetate c) sodium d) chloride

Sodium

Triazole is a

antifungal

With minoxidil, all these parameters should be monitored except: a) urine flow rate b) blood pressure c) pulse rate d) body weight

body weight

Allopurinol indications

prophylaxis from gout | treatment of high uric acid and calcium oxalate renal stones

famotidine is H2 antagonist used for

treatment of gastric and duodenal ulcers

type 1 diabetes advises to use

insulin

type 2 diabetes advises to use

sulphonylurea

Vasopressin is used in the treatment of

diabetes insipidus

enalapril is the prodrug of

enalaprilate

which one is prodrug: a) pivampicillin b) erythromycin c) ampicillin

pivampicillin

Cytotec is

used for gastric and duodenal ulcer | contraindicated in pregnancy

Simvastatin is used for

hypolipidemic action

acetohexamide is

hypoglycemic

Which of the ff is contraindicated in pregnancy? a) ciprofloxacin b) ethambutol c) chlorpheniramine d) sucralfate

ciprofloxacin

Which one of the ff is not contraindicated in pregnancy? a) methyldopa b) enalapril c) lisinopril d) captopril

methyldopa

All these medications are used in the treatment of T.B. except: a) INH b) Rifampicin c) Cycloserine d) Cyclosporine

Cyclosporine

INH means

isoniazid | isonicotinic acid hydrazide

Duration of treatment of TB by CTC

Six month and over

Amantadine is used for all of the ff except: a) antiviral b) for influenza A c) anti-parkinsonism d) for influenza B

for influenza B

All these drugs are antiviral except: a) amantadine b) zidovudine c) acyclovir d) aluerin

aluerin (anti spasmodic)

All are viral infection except: a) hepatitis B b) influenza c) herpes zoster d) rickettsia

rickettsia (bacteria)

Drugs to pass BBB should be

unionized lipophilic

Chloramphenicol affects liver inhibitory enzyme, so:

decrease metabolism and increases response

Which one is an OTC drug? a) simple analgesic b) warfarin c) ciprofloxacin

simple analgesic

What is the most drug can cause damage if it is given OTC?

warfarin

Morphine and morpin are similar in

addiction miosis analgesic

Oxytocin is one of the

posterior pituitary hormones

Phenylephrine is used for: a) decongestant b) for runny nose c) sympathomimetics d) vasoconstrictor and pressor e) all of the above

all of the above

Oxytocin produces all the ff except: a) mammalian glands stimulation b) uterine stimulation c) labor induction d) progesterone release

progesterone release

binding to plasma protein

increases half-life

new and best therapy for peptic ulcer is

four medicines including antibiotic

in case of osteoarthritis and peptic ulcer of elderly patients use

paracetamol

Suprax is

Cefixime

Which one is Sporanox?

Itraconazole

All these can be used in leprosy except: a) dapsone b) rifampicin c) clofazimine d) INH

INH

Betahistine dihydrochloride is used

antihistaminic | Meniere's disease

Maximum use of paracetamol

4gm in 24 hours

Metoclopramide is a dopamine antagonist

acts centrally by blocking chemoreceptor trigger zone acts peripherally has an anti-emetic effect

Cyproteron (Androcur) is used for

antiandrogen: decreased sexual ability

Immunocompetent means

low resistant to infections

Voltaren emulgel is

diclofenac diethylamine

Pneumocystis Carini Pneumonia (PCP) is

parasite

Which one of the ff is not antibiotic? a) erythromycin b) cefprozil c) cefpodoxime d) finasteride

finasteride

Used in Benign prostatic hyperplasia

Finasteride

Otrivin is

Xylometazoline

Which one of the ff is not mucolytic? a) bromhexine b) carbocisteine c) ambroxol d) guaifenesin e) dextromethorphan

dextromethorphan

All these are anti-platelets except: a) aspirin b) dipyridamole c) presentin d) ticlopidine e) streptokinase

streptokinase

All these are anti-coagulant except: a) warfarin b) ancord c) heparin d) dipyridamole

dipyridamole - antiplatelet

Anticoagulant effect of warfarin is decreased by

Vitamin K

Aspirin is recommended with one of the ff: a) anticoagulant b) chicken pox c) influenza symptoms d) dysmenorrhea

anticoagulant

Which one is not oral anticoagulant? a) warfarin b) nicoumalone c) phenindione d) enoxaparin

enoxaparin (DVT)

Phenobarbitone induces liver microsomal enzymes, when taken with warfarin leads to

increasing the activity of liver enzymes, so decreases the activity of warfarin

Drug which increases the action of warfarin: a) carbimazole b) oral contraceptive c) phenobarbitone d) none of the above

none of the above

Drug which decreases the action of warfarin - its antidote

vitamin K

Enzyme inducer

Rifampicin

Which one reduces the metabolism of other drugs in the liver?

Cimetidine

Heparin antidote

Protamine sulfate

Paracetamol antidote

acetylcysteine

warfarin antidote

vitamin K

Iron antidote

deferoxamine (chelating agent)

cyanide antidote

Na thiosulphate

Copper and Lead antidote

Penicillamine

Heavy metals antidote

dimercaprol (organic compound)

insulin and oral hypoglycemic antidote

dextrose

digoxin antidote

digoxin immune fab | protamine sulfate?

opioid antidote

naloxone

morphine antidote

naloxone

Hepatotoxicity is induced due to these drugs except: a) rifampicin b) ketoconazole c) quinolones d) dipyridamole

dipyridamole

Cause of death in morphine toxicity is

respiratory failure

to prevent more absorption of the toxic drug we use

charcoal

common side effect of sulphonylurea is

hypoglycemia

side effect of insulin are

local reaction (urticaria) hypoglycemia fat dystrophy at the side of injection

main side effect of insulin

hypoglycemia

pseudomembranous colitis is a side effect of

clindamycin

all of these are corticosteroids except: a) methyl prednisolone b) prednisolone c) triamcinolone d) beclomethasone e) dexamethasone f) ondansetron

ondansetron (5ht3 receptor antagonist, anti emetic)

all of these are anti-neoplastics, except: a) aldesleukin b) teniposide c) pentostatin d) amlodipine

amlodipine

levodopa is used with carbidopa for the treatment of

Parkinsonism

All of these are true for levodopa except: a) precursor of dopamine b) stimulates dopamine c) effective in parkinsonism d) does not pass BBB

does not pass BBB

Specific Serotonin reuptake inhibitors are used as

Antidepressant

Fluoxatine (Prozac) is

SSRI antidepressant | selective serotonin reuptake inhibitor

ondansetron hcl is used for

emesis

Which one is not 5HT3 antagonists? a) tropisetron b) ondansetron c) granisetron d) domperidone

domperidone - peripheral dopamine receptor antagonist

drug of choice for febrile convulsion in children is

dizepam 250mcg/kg

Which one is correct? a) diazepam is not used for long time b) diazepam is taken IM only c) diazepam is derived from morphine d) diazepam can cause muscle spasm

Diazepam is not used for long time

drug of choice in status epilepticus is

Diazepam

the ff are indications of Diazepam, except: a) antipsychotic b) epilepsy c) hypnotic d) headache

Headache

All of the ff used in treatment of anxiety except: a) propranolol b) diazepam b) mebrobamate d) homotropine

homotropine

All of these are anti-parkinsonism except: a) amantadine b) bromocriptine c) selegiline hcl d) lysuride e) pergolide f) levodopa g) primidone

Primidone

All these drugs can be used for Parkinsonism except: a) selegiline hcl b) carbidopa c) pergolide d) nedocromil sodium

nedocromil sodium

One of the ff is not used for epilepsy: a) clonazepam b) phenytoin c) primidone d) imipramine

imipramine

All of the ff are used in epilepsy except: a) sodium valproate b) carbamazepine c) phenytoin d) nedocromil sodium

nedocromil sodium

All of the ff are controlled drugs except: a) rivotril b) stesolid c) carbamazepine d) barbiturates e) diazepam f) primidone g) epanutin h) imipenem i) G and H

Epanutin | Imipenem

Controlled drugs present in pharmacy are

in tightly closed shelves

Vitamin B1

Thiamine HCl

Vitamin B2

Riboflavin

Vitamin B3

Niacine

Vitamin B5

Panthothenic acid

Vitamin B6

Pyridoxine HCl

Vitamin B9

Folic acid

Vitamin B12

Cyanocobalamine

Zidovudine is used for

HIV | AIDS

Drug used for HIV

Zalcitabine

Omeprazole actions

Proton pump inhibitor | blocks the hydrogen-potassium ATP enzyme system

MMR vaccine is

measles-mumps-rubella vaccine

maximum dose of captopril

150mg/day

schedule of immunization of HBV is

three dose

maximum recommended dose of ibuprofen is

3000

Child weighs 10kg, paracetamol dose for him is

100-150mg 4-6hrs

Maximum dose of diclofenac sodium is: a) 50 mg b) 75 mg c) 100 mg d) none of the above

none of the above | 150mg ?

Source of human insulin is e-coli by:

biosynthetically by recombinant DNA technology using e-coli | semi synthetically by enzymatic modification of protein material

When you store drug at low temperature you must consider the ff

storage of dusting powder below 0C causes accumulation of granules storage of cream and ointment below 5C causes cracking storage of insulin below 0C causes aggregation of insulin

insulin is preserved at

2-8C

All these drugs are antibacterial except: a) cefoperazone b) lomifloxacin c) zalcitabine

zalcitabine

Estrogen action

reduces the incidence of coronary diseases in postmenopausal women

Co-trimethoxazole contains

trimethoprim + sulphamethoxazole | 1:5

Which is not from quinolone group? a) nalidixic acid b) eoxacin c) nofloxacin d) ciprofloxacin e) ofloxacin g) sparfloxacin h) aminosidine i) quinine

Quinine | aminosidine

Quinolone are contraindicated in children because

affect joints

sumatriptan is used for

treatment of migraine and headache

Benzyl peroxide is a local treatment for

acne vulgaris

drug of choice for treatment of amoebae

metronidazole

The steady state concentration of the drug in the plasma depends on

direct proportion to the rate of elimination

Mechanism of action of vitamin K

synthesis of coagulation factors by hepatic cells and increases formation of clotting factors

elimination of digoxin is mainly by

kidney

Drug physical dependence is as same as drug abuse

True

Terbinafine dosage form

local and systemic

Miconazole dosage form

local and systemic

Amphotericin dosage form

parenteral only

Griseofulvin dosage form

oral

Terbinafine is used topically for

fungal infection

Amiloride as a treatment causes

hyperkalemia

Moduretic is a combination between

amiloride + hydrochlorothiazide

Gemfibrozil indication

hyperlipidemia

Cisapride indication

gastro-oesophageal reflux

Fluoxetine indication

SSRI as sedative serotonin reuptake inhibitor

Carbimazole indication

hyperthyroidism

Imipramine indication

tricyclic antidepressant

Teicoplanin antibiotic has similar effect on gram positive bacteria as

vancomycin

Which one is not tetracycline? a) minocycline b) demeclocycline c) doxicycline d) clindamycin

clindamycin

Tetracycline taken with Ca and Mg

poorly absorbed compound from GIT

Use of tetracycline in its expiry date

Fanconi syndrome

Tetracycline when taken with minerals such as calcium, iron, and aluminium forms a chelate which is

inactive and poorly absorbed

Which is not true with tetracycline? a) broad spectrum bacteriostatic b) used for acne c) inhibits protein synthesis d) broad spectrum bactericidal

broad spectrum bactericidal

Mesalazine is used for

treatment and maintenance of remission of ulcerative colitis

four lipid soluble vitamins

vitamin A, D, E, and K

Imipenem (carbapenem)

the first thienamycin B-lactam antibiotic

Bioavailability of the drug is:

rate of absorption | extent of absorption

Biotransformation is

less lipid soluble

Diseases causeing edema

renal failure | congestive heart failure

All of these are third generation cephalosporin except: a) cefixime b) cefpodoxime c) ceftriaxone d) cefotaxime e) none of the above

none of the above

Which one is not a benzodiazepine? a) temazepam b) nitrozepam c) loprazolam d) clozapine

clozapine

Oral rehydrate solution

NaCl + K citrate + Na citrate + glucose

Gemfibrozile moa

increases HDL and decreases triglycerides

Drugs that need monitoring for their serum level

amikacin warfarin theophylline digoxin

For flucloxacillin, all these statements are wrong except: a) it is better absorbed than cloxacillin b) it is taken by oral route only c) it is activated by penicillinase enzyme d) it is base stable

it is better absorbed than cloxacillin

What are the instruction for the patient take Metamucil or any other bulk foaming laxative as Bran, methyl cellulose and psyllum?

adequate fluid intake should be maintained to avoid intestinal obstruction

Drugs from HMC CoA reductase inhibitor

simvastatin provastatin fluvastatin

HMGCoA reductase inhibitor is

3 hydroxy, 3 Methyl Glutoryl CoA reductase inhibitor

Calciferol is

1.25 dihydroxy calciferol

Pharmacodynamic means

physiological and biochemical effect of the drug on the body

Pharmacokinetic means

physiological and biochemical effect of the body on the drug

Sympathomimetic drugs

increase blood pressure increase coronary flow increase heart rate

most common chemical structure of iron in drug is

ferrograd (ferrous sulphate)

Ferrograd is

ferrous sulphate

isomack 20mg tablets taken twice daily at time interval between

8am - 11pm

Valtrex is

acyclovir

Keflex is

1st generation cephalosporin | Keflex is Cephalexin

Micromedex is a

computer system

How much lidocaine for solution of 1/1000 to obtain 30cc

When drug is used for UTI it should be

G-ve

One of the ff is not NSAID a) xefo b) voltic c) parafon d) none of the above

Parafon

Intrathecal means

interjoint

Patient having constipation not to take

morphine

natural emulsifying agent

gum acacia

olive oil + water + asq gives

emulsion

isoptin is present in market in concentration

240 and 80 mg

Isoptin is used in treatment of

supraventricular arrhythmia

all of these are precaustions of becotide except

used only at the attack of asthma

alcohol present in pharmacy as antiseptic is in concentration

70%

Klaci is used every

12 hours

Intralipids are

o/w emulsion

Zantac contains

ranitidine

Which is present in balms or liniments and not used in burns?

methyl salicylate

drug of choice for head lice

pyrethrins

preparation used as otic drops for dewaxing

5% glycerin bicarbonate

Disulfiram is used for

chronic alcohol dependence liver cells protection prevention of conversion of acetaldehyde to acetic acid

drug metabolism in the body occurs in

liver, kidney and bowel mucosa

protein binds to drug forming a compound which is

inactive while the free part is active

drug transfers through cell membrane by

lipid dissolves

clonidine is used as

antihypertensive | migraine

New non-selective antihistamines act through

H1 antagonist

Non-sedating anti-histamines

Loratidine Cetirizine Terfenadine

What is astemizole

long acting non-sedating anti-histamine

Atropine is used as pre-anaesthetic to

decrease saliva

Metoclopramide gives anti-emetic effect through

peripheral action dopaminergic receptor muscarinic receptors

All of the ff are macrolides except: a) clarithromycin b) roxithromycin c) erythromycin d) apiramycin e) azithromycin f) sisomicin g) clindamycin h) f and g

sisomicin | clindamycin

Tilade inhaler generic name

Nedocromil sodium

Main use of metronidazole

anti amoebiasis

Benzyl peroxide is alcohol treatment for

acne vulgaris

Teicoplanin antibiotic affect on G+ve bacteria similar to

vancomycin

All these are broad spectrum cephalosporin except: a) cefexime b) cefuroxime c) cefotaxime d) cefopodoxime

cefuroxime

Which aminoglycoside antibiotic can be taken orally?

neomycin sulphate

NOT an aminoglycoside

Lymecycline

Side effects of aminoglycosides

nephrotoxicity | ototoxicity

example of drug inducing nephrotoxicity

aminoglycosides as gentamycin

baclofen is used for

natispasticity with spinal site of attack

Praziquantel used for Bilharziasis

causes loss of intercellular calcium of the worm | trade name biltricide

acitretin is used for

oral treatment of severe forms of psoriasis and disorders of keratinization

Which of the ff has no vasodilating effect? a) methyldopa b) hydralazine c) prazosin d) enalapril

methyldopa

Patient with G6PD deficiency, the drug may cause hemolysis

sulphonamide

G6PD deficient patients must not take

Co-trimoxazole (sulphonamide)

pentobarbital idffers from phenobarbital in

faster action

Glucocorticosteroids used in

bronchial asthma | addison disease

use of calcitonin

To lower plasma Ca concentration in some patients with hypercalcemia relieving neurological complications treatment of Paget disease

Diabinese generic

chlorpropamide

Daonil and Euglocon generic

glibenclamide

Diamicron generic

glicazide

Minidiab generic

glipizide

Rastinon generic

tolbutamide

Dimilor generic

acetohexamide

amaryl generic

glimipiride

Hyoscine N butyl bromide brand

Buscopan & Scopinal

Propantheline bromide brand

Probanthine

Oxyphenonium brand

Anternyl

Mebeverine HCl brand

Duspatalin

Alverine brand

Spamonal

Diclofenac sodium brand

Voltaren

Fenbufen brand

Cinopal

Diflunisal brand

Dolobid

Indomethacin brand

Indocid, indogesic and Rothacin

Ketoprofen brand

Profenid

Naproxen brand

Naprosyn

Cloroquine brand

Malarex & resochin

Pyremethamine + Sulfadoxine brand

Pansidar

Pindolol brand

Visken

Baclofen brand

Lioresal

Isotretinoin brand

Roaccutane

Hexoprenaline brand

Ipradol

Khellin brand

Lynamine

Pivampicillin brand

pondocillin

Bufexamac brand

Droxaryl

Codergocrin brand

hydergine

Acarbose brand

Glucobay

Use of gentian violet

antiseptic | skin disinfectant

The concentration of crystal violet paint is

2.5% according to B.P. 1980 | 1% according to U.S.P. 1985

What is the concentration of mercurochrome solution?

Sustained release tablets depend on

pH of stomach

When newly married don't want children, how to arrange

Send the wife to the family doctor

Pharmacy of central hospital is

central pharmacy only | contains store

a patient takes phenytoin and his hair has less growth. You advise him

go to doctor

Roaccutan is prescribed to patient who is women 22 years old, you ask?

If she is pregnant

If you have prescription containing Inderal & the patient is wheezing, what is your advice?

Call the doctor

Patient has hepatic disease & type II diabetics take

rosiglitazone or piaglitazone (Avandia, Glustin)

A patient has a prescription of Enalapril + KCL, what do you ask him?

none of the above

Reserpine not used with parkinsonis patient take

levodopa

controlled drug for ophthalmic prep due to

increase half life

CCB not used in

AV node heart block

All are alkylating except

flurouracil

drug make Na/water retention

minoxidil

Phenylephrine is a

alpha 1 agonist only

gas to solid

deposition

azelastine is

antihistaminic

hormone secreted from adrenal cortex

aldosterone

digoxin effect all except

decrease vagal tone to heart

zidovudine side effect

anemia

baclofen used as

muscle relaxant

zonisamide is broad spectrum

anti epileptic

Propantheline is contraindicated in

glaucoma myesthenia gravis obstructive disease GIT ulcerative colitis

low molecular weight heparin

tinazaprin enoxaparin deltaprin

NSAID in parenteral form

ketorolac

not effect of prednisolone or betamethasone

arthritis | hypoglycemia

acetylcysteine is a

mucolytic

alpha 2 receptor activation cause

decrease BP

isoproterenol moa

non selective b1 and b2 agonist

all effect of digoxin except

increase conduction of AV node

domperidone used in

nausea and vomiting

not related to heparin

lyse the existing clot

diuretics used to

increase urine formation

not ACEis

isopten

diltiazem role in angina

decrease o2 demand by blocking ca influx

all drug treat parkinsonism except

tofanil

rate of reaction increase with

increase temperature

antimetabolite drug

gemcitabine

side effect of atropine

urine retention

partition coefficient is used to determine

dissolution rate constant | drug storage in fat

Sodium nitroprusside is a

vasodilator

phase 1 arrhythmia

initial depolarization is due to k efflux

multidrug resistance occurs due to the function of

p-glycoprotein

loop diuretics does NOT cause

hypernatremia

angina present with

chest pain

verapamil can increase action/synergism of

digoxin

rate of absorption depend on

hyoscine and propantheline SE all except

difficulty breathing

quinidine class 1a

slow phase 0

thiazide SE except

hyperkalemia

cephalosporin act by

inhibit cell wall synthesis

NSAID moa

inhibit pg synthesis

omeprazole moa

ppi h/k atpase inhibitor

drug changes color of teeth

tetracycline

active part of primidone

phenobarbital

reserpine all except a) inhibit dopamine decarboxylase b) bbb c) orally effect

inhibit dopamine decarboxylase

ACEi SE all except a) glucose tolerance b) hyperkalemia c) hypotension d) dry cough

glucose tolerance

all are effects of digitalis except: a) +ve chronotropic b) decrease heart size c) +ve inotropic d) slow conduction av node

+ve chronotropic

controlled drug delivery for eye preparation is used due to

drug needed for long duration of action

not effect of reserpine

weight loss | protein urea

prazosin act through

post synaptic alpha blocker

clonidine is a

alpha 2 agonist

cyclovir ttt keratitis caused by

herpes simplex

not side effect of marijuana

anorexia

phenytoin + digoxin

increase microsomal enzyme

MOA of diazepine

GABA agonist

substance reduce release of catecholamine from vesicles

reserpine

use of phenytoin other than epilepsy

antiarrhythmic class Ib

exaggerate glucose levels

thiazide

lacidipine is a

calcium channel blocker

phospholine iodide

ecothiopate | forms stable complex with cholinesterase

absorption of drug from small intestine to liver through

mesenteric vein to portal vein

colestipol moa

increases lipoprotein excretion

solid to vapour

sublimation

parkinsonism associated with

muscle rigidity

nitric oxide disadvantage

not fully produce surgical anesthesia

2ppm =

2mg

dantrolene moa

blocks Ca

agranulocytosis caused by

thiouracil

folic acid dose

400-500

ibuprofen dose

450

bacitracin is used

topically

disturbed and aggressive patient use

haloperidol

kapsi sarcoma

alpha-interferon

warts treatment

gluteraldehyde

phenytoin decrease action of digoxin by

increase microsomal metabolism

drug causes dependence

amphetamine

pancuronium is a

skeletal muscle relaxant

perphenazine is used in

antipsychotic and nausea and vomiting

colestyramine is used for

lower high levels of cholesterol

captopril brand name

capoten

diclofenac in arthritis

analgesic and anti inflammatory only

main mechanis of nitroglycerin

relaxation of vascular muscle

transient pressor effect associated with

clonidine | guanethidine

side effect of digoxin treatment

arrhythmia

drug need monitoring when taken with verapamil

digoxin

all about epinephrine is true except

cause chest pain

cause of angina

increase o2 demand more than o2 supply

hyperthyroidism initiated by

increases action of warfarin

amiodarone

class 1b anti arrhythmia

lidocaine

phase 3 muscle contraction due to

repolarization due to ca influx

cause of bronchospasm: a) pindolol b) isoprenaline

pindolol

Review Questions Flashcards

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