RH

Question 1

The Rh system genes are:
a. RHD and RHCE.
b. RHD and LW.
c. RHD and RHAG.
d. RHCE and RHAG.

Answer 1

A

Question 2

RHD and RHCE are proposed by __________; Located on chromosome ____

Answer 2

Tippett; 1

Question 3

RHAG gene is located on chromosome ____

Answer 3

6

Question 4

RHAG gene can express any Rh antigen. RHD controls the expression of RhD.

A. S1 is true
B. S2 is true
C. Both are true
D. Both are False

Answer 4

B

Question 5

Presence of 3 separate genes D,C,E and alleles c and e

Answer 5

Fisher-Race (DCE Nomenclature)

Question 6

Most common in blacks (Weiner)

Answer 6

R0r

Question 7

Most common in Asians/Whites

Answer 7

R1r

Question 8

African-Americans

Answer 8

R0>r>R1>R2

Question 9

Caucasians

Answer 9

R1>r>R2>R0

Question 10

A system that assigns a number to each antigen in order if its discovery or recognized relationship to the Rh system

Answer 10

Rosenfield (Alpha-numeric Terminology)

Question 11

ISBT

Answer 11

International Society of Blood Transfusion

Question 12

In ISBT Nomenclature, the first 3 numbers represent the system, While the Last 3 numbers represent the ANTIGENIC SPECIFICITY.

Answer 12

A. Only one statement is true
B. Both statements are true
C. None of the statements are correct.

Question 13

Correct order of Immunogenecity:

Answer 13

D>c>E>C>e

Question 14

Common in Blacks, No or weak with anti-D

Answer 14

Weak D

Question 15

Weak D is detected by _________

Answer 15

Indirect Antihuman Globulin Test

Question 16

Allele carrying RHD is in trans position with the allele carrying C

Answer 16

C in Trans to RHD

Question 17

Anti D is fewer in number but still completely expressed

Answer 17

Genetic Weak D

Question 18

Missing or altered D protein epitope

Answer 18

Partial D

Question 19

Rh of a Partial D donor

Answer 19

Rh Positive

Question 20

Rh of a Partial D recipient

Answer 20

Rh negative

Question 21

Increased number of D antigens on RBC

Answer 21

Rh Deletion

Question 22

Antigen is not expressed on RBC due to an abnormality in Transmebrane Protein

Answer 22

Rh null

Question 23

Type of Rh null that has mutation in RHCE, Deletion of RHD and Normal RHAG gene

Answer 23

Amorphic type of RH Null

Question 24

Type of RH null that has mutation in RHAG gene

Answer 24

Regulator Type

Question 25

Partial suppression of RH gene; weakened Rh antigen expression

Answer 25

Rh mod

Question 26

A compound antigen; expressed when 'c' and 'e' are in cis position = f antigen

Answer 26

f (ce)

Question 27

Caused by single amino acid change on RhCe protein

Answer 27

Cw

Question 28

A compound antigen; expressed when 'C' and 'e' are present

Answer 28

rhi (Ce)

Question 29

Present on most D+ and C+ RBCs

Answer 29

G (DC)

Question 30

Strong D expression because of no Cc/Ee

Answer 30

Exalted D

Question 31

Most clinically significant IgG

Answer 31

IgG1 and 3

Question 32

IgG for complement fixation

Answer 32

IgG3>IgG1>IgG2

Question 33

Best at crossing placenta

Answer 33

IgG1>IgG4>IgG3

Question 34

Greatest significance because RBCs coated with these are c leared in the RES

Answer 34

IgG1/IgG2

Question 35

Antigen present on Rhesus monkey and on majority of human RBCs

Answer 35

Landsteiner-Weiner blood group system

Question 36

LW gene is on chromosome ____; Antigen is carried by ________

Answer 36

19, ICAM-4

Question 37

Differentiate D antigen to LW antigen

Answer 37

DTT or Dithiothreitol

Question 38

Specimen used for routine RH typing

Answer 38

Whole blood or RBC suspension

Question 39

What Rh antigen is found in 85% of the Caucasian pop- ulation and is always significant for transfusion purposes? a. d b. c c. D d. E

Answer 39

C

Question 40

How are weaker-than-expected reactions with anti-D typing reagents categorized? a. Rhmod b. Weak D c. DAT positive d. Dw

Answer 40

b

Question 41

Cells carrying a weak D antigen require the use of what test to demonstrate its presence? a. Indirect antiglobulin test b. Direct antiglobulin test c. Microplate test d. Warm autoadsorption test

Answer 41

A

Question 42

How are Rh antigens inherited? a. Autosomal recessive alleles b. Sex-linked genes c. Codominant alleles d. X-linked

Answer 42

C

Question 43

Biochemically speaking, what type of molecules are Rh antigens? a. Glycophorins b. Simple sugars c. Proteins d. Lipids

Answer 43

C

Question 44

Rh antibodies react best at what temperature (°C)? a. 15 b. 18 c. 22 d. 37

Answer 44

D

Question 45

Rh antibodies are primarily of which immunoglobulin class? a. IgA b. IgD c. IgG d. IgM

Answer 45

C

Question 46

Rh antibodies have been associated with which clinical condition? a. Hemolytic disease of the fetus and newborn b. Thrombocytopenia c. HemophiliCa A d. Stomatocytosis

Answer 46

A

Question 47

What do Rhnull cells lack? a. Lewis antigens b. Normal oxygen-carrying capacity c. Rh antigens d. Hemoglobin

Answer 47

C

Question 48

Convert the following genotypes from Wiener nomen- clature to Fisher-Race and Rosenfield nomenclatures, and list the antigens present in each haplotype. a. R1r b. R2R0 c. RzR1 d. r'r

Question 49

Which Rh phenotype has the strongest expression of D? a. DCe/ce b. DCe/DCe c. DcE/DcE d. D–

Answer 49

D

Question 50

An individual has the following serologic reactions: D+C+E+c+e+f–. What is the most probable genotype? a. R1R2 b. R0ry c. Rzr d. R1r"

Answer 50

A

Question 51

Which of the following is the most common haplotype in the African American population? a. DCe b. DcE c. Dce d. ce

Answer 51

C

Question 52

If a patient who is R1R1 is transfused with RBCs that are Ror, which antibody is he most likely to produce? a. Anti-D b. Anti-c c. Anti-e d. Anti-G

Answer 52

B