rh blood group

Question 1

based on the theory that antigen of the systems were produced by three closely linked set of alleles, each gene was responsible for producing a product

A. FISHER RACE
B. WEINER
C. ROSENFIELD
D. ISBT

Answer 1

FISHER RACE

• BASED ON THEORY
• EACH GENE IS RESPONSIBLE FOR PRODUCING A PRODUCT

Question 2

what is the order of immunogenicity

a. D> C > E > c > e
b. D > c > e > C > E
c. D > c> E > C > e

Answer 2

c. D > c> E > C > e

Question 3

one gene responsible for defining Rh that produced an agglutinogen containing a series of blood factors

A. FISHER RACE
B. WEINER
C. ROSENFIELD
D. ISBT

Answer 3

Wiener: Rh-Hr terminology
- Wiener believed there was one gene responsible for defining Rh that produced an agglutinogen containing a series of blood factors

Question 4

which of the following is alpha numeric

A. FISHER RACE
B. WEINER
C. ROSENFIELD
D. ISBT

Answer 4

rosenfield (alpha numeric)

Question 5

which numenclature has no genetic basis

A. FISHER RACE
B. WEINER
C. ROSENFIELD
D. ISBT

Answer 5

Rosenfield (Alpha numeric)

• Number is assigned to each antigen of the Rh system in order of its discover
• the nomenclature has no genetic basis

D = Rh1 C =Rh2 E= Rh3 c= Rh4 e= Rh5

Question 6

in ISBT : numeric terminology , the first number represents the ___

a. system
b. blood group
c. rh
d. antigenic specificty

Answer 6

International Society of Blood Transfusion (ISBT) : Numeric terminology

• Adopted a six-digit number for each blood group specificity
• First three number represents the SYSTEM and the remaining three represents the ANTIGENIC SPECIFICTY
• Establish a uniform nomenclature that is both eye and machine readable

Question 7

what is short hand for DcE

a. R0
b. R1
c. R2
d. r2

Answer 7

DcE

short hand
- R2

long hand
- Rh0 hr’ rh’’

Question 8

R1 is commonly seen on

a. black individuals
b. native
c. asian
d. white individuals

Answer 8

R1 / DCe
-can be found in WAN

W - white
A - asian
N - native

Question 9

R0 is commonly seen on

a. black individuals
b. native
c. asian
d. white individuals

Answer 9

R0 / Dce

- can be found in Black individuals

Question 10

D antigens expressed appear to be complete, but few in number

a. genetic weak D
b. C trans to D
c. D mosaic
d. Del

Answer 10

Genetic weak D

D antigens expressed appear to be complete, but few in number

Question 11

Positional effect

a. genetic weak D
b. C trans to D
c. D mosaic
d. Del

Answer 11

C Trans to D

Positional effect or gene interaction effect

Allele carrying D is trans (opposite haplotype) to the allele carrying C

Question 12

One or more parts of the D antigen is missing.

a. genetic weak D
b. C trans to D
c. D mosaic
d. Del

Answer 12

D mosaic or Partial D

One or more parts of the D antigen is missing. 

The expression can be weakened is when one or more D epitopes within the entire D protein is either missing or altered

Question 13

Phenotype whose red blood cells possesses an extremely low number of D antigen that most reagent anti-D are unable to detect

a. genetic weak D
b. C trans to D
c. D mosaic
d. Del

Answer 13

Del

• Phenotype whose red blood cells possesses an EXTREMELY LOW NUMBER OF D ANTIGEN that most reagent anti-D are unable to detect
• due to mutation of RHD gene
• common in individuals of ASIAN ethinicity

Question 14

which of the following unusual phenotypes is known a crawford antigen

a. f (ce)
b. Rh43
c. Rh:40
d. Cw

Answer 14

RH43
also known as CRAWFORD ANTIGEN
low prevalence antigen on a variant Rhce protein

Question 15

which of the following unusual phenotypes has been called compound antigen

a. f (ce)
b. Rh43
c. Rh:40
d. Cw

Answer 15

The f antigen is expressed on the RBC when both c and e are present on the same haplotype. It has been called a compound antigen

Question 16

anti - f wil react to which of the following phenotype

a. R1R2
b. R1R1
c. R2R2
d. rr

Answer 16

R1R1 - DCe/DCe
R1R2 - DCe/DcE
R2R2 - DcE/DcE
rr - dce/dce

ans: rr/ d