rh blood grp Flashcards
(21 cards)
One of the most polymorphic & immunogenic system inhumans
Rh blood group system
has the most (50) antigenic forms
Polymorphic
refers to a specific blood group Antigen D & to a complex blood group system currently composed of over 50 different antigenic specificities.
Rh
How can you expose an Rh negative person to a positive D-Ag?
Wrong blood type is given
what year???
Obstetric Px delivered a stillborn infant, transfused with ABO complicate blood (from husband) and showed signs of AHTR (Acute Hemolytic Transfusion Reaction) Ab were isolated that reacted @ 37C & 20C with the husband’s RBCs
1960s
Obstetric Px delivered a stillborn infant, transfused with ABO complicate blood (from husband) and showed signs of AHTR (Acute Hemolytic Transfusion Reaction) Ab were isolated that reacted @ 37C & 20C with the husband’s RBCs
REPORTED BY???
Levine & Stetson
an Ab made by guinea pigs & rabbits when transfused with blood from Rhesus macaque monkey RBCs.
WHO REPORTED?
Landsteiner & Weiner
an Ab made by guinea pigs & rabbits when transfused with blood from Rhesus macaque monkey RBCs.
WHAT YEAR???
1930
human produced Ab
Anti-Rhesus
formed by the animals
Anti-LW
Rh is a primary cause of
HDFN
There are technically __ base Ag in the Rh blood group system
5 base Ag
Rh Gene resides in Chromosome 6
RHAG
▪ Must be present for successful expression of Rh antigens
▪ Maybe called as the “H antigen” of the Rh blood group system
Rh Associated glycoprotein (RhAg)
all forms inherited will show up
Codominance
not highly antigenic unlike D
C
Donor should not have ___________ because it will lead to the sensitization of the recipient. Meaning, the body will automatically produce Ab against that Ag because it is foreign.
too much antigens
DCE Terminology
Fisher-Race
Rh Terminology Commonly used in the hospital
Fisher-Race
Rh-Hr Terminology
Wiener
Numeric Terminology
Rosenfeld & coworkers
ISBT
