Flashcards in Rhabdovirus Deck (11):
Rhabdoviruses include? whats main one?
Vesiculovirus (vesicular stomatitis viruses)
adsoprtion via attachment G protein
replicates in cytoplasm
no clinical signs
Virus travelling to CNS. travels within axons via retrograde fast axonal transport. replicates in motor neurons of spinal cord. travels up dorsal root ganglion..
SYMPTOMS: fever, nausea, vomiting, loss of appetite, lethargy, headache.
Infection of the brain neurons. hippocampus, brainstem, pontine nuclei, purkinje cells of cerebellum, travels to salivary glands, cornea, other organs.
hydrophobia, pharyngeal spasms, hyperactivity, anxiety, depresion, loss of coordination, paralysis, dellerium, donfusion, coma, death.
zoonotic, wildlife and unvaccinated pets.
saliva of rabid animals.
(minorly spread via aerosols of bat caves.)
neurological symptoms = too late for treatment(you dying)
antigen detection: IF or genome detection by RT-PCR
Negri bodies in affected neurons (biopsy)
ELISA for rabies antibody in serum and CSF
postexposure rabies vaccine (4 within 2 weeks).
Always fatal unless treated with postrabies immunization. One case of successful cessation of disease.