Rhabdovirus Flashcards Preview

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Flashcards in Rhabdovirus Deck (11):
1

Rhabdoviruses include? whats main one?

Vesiculovirus (vesicular stomatitis viruses)
Lyssavirus: RABIES

2

Rhabdo structure

-bullet shaped
-enveloped
- -ssRNA

3

Replication

adsoprtion via attachment G protein
replicates in cytoplasm

4

Phases

Incubation phase
Prodromal phase
neurologic phase

5

Incubation phase

no clinical signs

6

Prodromal phase

Virus travelling to CNS. travels within axons via retrograde fast axonal transport. replicates in motor neurons of spinal cord. travels up dorsal root ganglion..
SYMPTOMS: fever, nausea, vomiting, loss of appetite, lethargy, headache.

7

Neurological phase

Infection of the brain neurons. hippocampus, brainstem, pontine nuclei, purkinje cells of cerebellum, travels to salivary glands, cornea, other organs.
SYMPTOMS:
hydrophobia, pharyngeal spasms, hyperactivity, anxiety, depresion, loss of coordination, paralysis, dellerium, donfusion, coma, death.

8

Epidemiology

zoonotic, wildlife and unvaccinated pets.
saliva of rabid animals.
(minorly spread via aerosols of bat caves.)

9

Diagnosis

neurological symptoms = too late for treatment(you dying)
antigen detection: IF or genome detection by RT-PCR
Negri bodies in affected neurons (biopsy)
ELISA for rabies antibody in serum and CSF

10

Treatment

postexposure rabies vaccine (4 within 2 weeks).
Always fatal unless treated with postrabies immunization. One case of successful cessation of disease.

11

Rabies Vaccine

Killed-Virus vaccine
chemical inactivation of rabies infected-tissue culture human diploid cells.
Animal workers and lab workers receive preexposure vaccination.