Rheum Test 2 Flashcards
(133 cards)
Which of these are ways that an antibody can cause autoimmunity?
a. Opsonize penicillin on a RBC
b. Bind to a pathogenic toxin
c. All of these can be true
d. Bind and stimulate a self-receptor
Bind and stimulate a self-receptor
Antibody to the nicotinic acetylcholine receptor causes:
a. Autoimmune hemolytic anemia
b. Myasthenia Gravis
c. Graves disease
d. Lupus
Myasthenia Gravis
In lupus, the antigens are from
a. the nucleus
b. the liver
the nucleus
The mechanism of type 1 diabetes mellitus is:
a. None of these are true
b. CD8 T cells kill pancreatic alpha cells
c. CD8 T cells kill pancreatic beta cells
d. Antibodies block insulin production
CD8 T cells kill pancreatic beta cells
When a macrophage eats a self-antigen and then is stimulated by a pathogen to produce CD867, it’s called
a. bad luck
b. antigen redirecting
c. bystander effect
d. epitope spreading
bystander effect
Multiple sclerosis happens when:
a. There is acute ascending inflammatory demyelination that starts in the lower extremities and ends in the upper limbs and face
b. Antibody to acetylcholine receptor blocks transmission leading to numbness and tingling
c. A toxin causes paralysis, starting in the intestines and moving into the extremities
d. There are numerous areas of demyelination within the brain and spinal cord without axonal degeneration
There are numerous areas of demyelination within the brain and spinal cord without axonal degeneration
In MS, the cell responsible for killing the oligodendrocyte is the
a. Inflammatory macrophage
b. Natural Killer T cells
c. CD8 T cell
d. Complement
CD8 T cell
THe major cytokines involved in Rheumatoid Arthritis joint damage are:
a. TGF beta and IL-17
b. IL-4, IL-5, IL-13
c. TNF alpha and IL-1
d. IFN gamma and IL-2
TNF alpha and IL-1
Your patient is a 38 year-old Hispanic executive director of a local non-profit. She is tired and fatigued. She’s a little overweight, but not excessively so. She is married and has 4 children. She has been tested for anemia, common infections, and Lyme disease, and those tests have been negative. After examining her dry skin and peripheral neuropathy, you test for Hashimoto’s. If she’s in the early stages of Hashimoto’s, which of the following would you expect to find?
a. High T3, low TSH
b. Anti-TPO
c. High TNF alpha
d. Antinuclear antibodies
Anti-TPO
Your patient comes in complaining of anxiety and irritability. You notice her hands are shaking, and she drops the pen when she’s filling out her paperwork. She seems hot to the touch, when you put your hand on her shoulder. You suspect autoimmunity. Which test would you run for which disease?
a. Look for anti-TSH for Graves disease
b. Look for anti-acetylcholine for Myasthenia Gravis
c. Look for anti-MBP for MS
d. Look for anti-TPO for Hashimoto’s
Look for anti-TSH for Graves disease
Astragalus mongolicus is contraindicated in
a. Those prone to infection
b. Children
c. Those with autoimmune conditions
d. Geriatric populations
e. Those with cancer
Those with autoimmune conditions
Astragalus mongolicus is an example of a
a. Immunostimulant
b. Immunomodulator
c. Immunosuppressant
Immunomodulator
Which of the following are active constituents of Astragalus mongolicus?
a. Caffeic acid esters
b. Baicalin
c. Wogonoside
d. Triterpene saponins
Triterpene saponins
What are the mechanisms of immunostimulants
a. Increased phagocytosis
b. Increased production of white blood cells
c. Modulation of cytokines
d. All of these are mechanisms
All of these are mechanisms
Immunomodulators are
a. Heating, stimulating and drying
b. Cooling and tonifying
Cooling and tonifying
Echinacea purpurea may be used for the following conditions
a. Meningitis
b. Sepsis
c. Arthritis
d. GERD
e. Treatment of URI’s
f. Prevention of URI’s
Prevention of URI’s
Meningitis
Sepsis
Echinacea purpurea
a. Increases the Th2 response
b. Decreases the Th1 response
c. Decreases the Treg response
d. Increases the Treg response
Decreases the Treg response
Echinacea purpurea’s effects on the body are
a. Anti Inflammatory
b. Proinflammatory
c. Neither
d. Both
both
What is the effect of Scutellaria baicalensis on cytokines?
a. Inhibition of IFN alpha
b. Inhibition of IFN gamma
c. Stimulation of IL-10 and IL-12
d. All of these are true
All of these are true
Scutellaria baicalensis has been found to
a. Stimulate TNF alpha
b. Inhibit TNF-alpha
c. Both
d. Neither
both
What are the actions of Scutellaria baicalensis
a. Nephroprotective
b. Hepatoprotective
c. Cardioprotective
d. Neuroprotective
e. Pulmoprotective
Cardioprotective, Neuroprotective, Hepatoprotective
Echinacea purpurea has a dose dependent response
Select one:
True
False
true
The price of DMARDs creates challenges of affordability and access to many patients with rheumatological conditions (the ethical area of “pharmacoeconomics”). This barrier may be mitigated by providing advocacy to a patient by
a. Considering if there is a cheaper method of administration of the medicine besides oral administration
b. Provide contact information to the drug company who may offer discounts
c. Provide contact information to agencies that help with drug costs
a. Considering if there is a cheaper method of administration of the medicine besides oral administration
b. Provide contact information to the drug company who may offer discounts
c. Provide contact information to agencies that help with drug costs
When working with a patient with an advanced rheumatological condition that has led to disability, it is important to recognize and work to mitigate the health impact of additional health disparities they may face. Research indicates persons with disabilities can also experience
a. Lower rates of heart disease
b. Higher rates of smoking
c. Lower rates of obesity
d. Higher rates of regular exercise
Higher rates of smoking