Rheumatoid Arthritis Flashcards
What is Rheumatoid Arthritis?
An autoimmune condition which causes chronic inflammation in the synovial lining of the joints, tendon sheaths and bursa
Rheumatoid arthritis is associated with what gene?
HLA DR4 and. Anti CCP Antibodies
Rheumatoid Arthritis presentation?
Symmetrical distal polyarthritis affecting small joints of hands and feet. Usually MCP, PIP, Wrist and MTP.
Tenderness and Synovial Thickening = Boggy Feeling
Hand signs in Rheumatoid arthritis?
Swan Neck Deformity
Boutineere Deformity
Ulnar Deviatioj
Extra articular manifestations of Rheumatoid Arthritis?
Pulmonary Fibrosis
Felty’s Syndrome (RA, Neutropenia and Splenomegaly
Sjogrens
Lymphadenophy
Carpal Tunnel
Episcleritis
Scleritis
Diagnosing Rhuematoid Arthritis
Urgent Rheumatology Referral
Bloods: Rheumatoid Factor, Anti CCP Antibodies, CRP, ESR
Xrays
X Ray changes in Rheumatoid arthritis
Periarticular osteopenia
Boney erosions
Scoring in Rheumatoid Arthritis
Health Assessment Questionnaire
Disease Activity Score 28
Management for Rheumatoid Arthritis
Methotrexate
Steroids
DMARDS
Hydrocxychloroquine
Biologics eg Infliximab
Name common Sulfasalazine side effects
Orange Urine
Reversible male infertility
Bone marrow suppression
Name common Hydroxychloroquine side effects
Retinal Toxicity
Blue-grey skin pigmentation
Hair lightening
Anti TNF medications can reactivate what?
Tuberculosis
Ritixuimab side effects
Night sweats and Thrombocytopenia
