Rheumatoid Arthritis and Gout Drugs list Flashcards Preview

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Flashcards in Rheumatoid Arthritis and Gout Drugs list Deck (45):
1

Name the non-selective NSAIDs...

Indomethacin
Naproxen

2

Name the selective NSAIDs...

COX-2 inhibitors

3

What are the therapeutic uses of Indomethacin and Naproxen?

Rheumatoid arthritis and acute gouty arthritis

4

What are the therapeutic uses of COX-2 inhibitors?

Superseding conventional NSAIDs for rheumatoid arthritis

5

What are the 2 mechanisms of action for Indomethacin, Naproxen, and COX-2 inhibitors?

Eliminate pain and reduce inflammation

6

What are 2 non-selective NSAIDs and one selective NSAID used for the elimination and pain and reduction of inflammation?

Indomethacin and Naproxen are non-selective

COX-2 inhibitors are selective

7

Name the two main side effects seen from indomethacin and Naproxen... What alternative drug can be used to reduce these side effects?

Gastric and duodenal ulcers

COX-2 inhibitor-- 50% fewer gastric and duodenal ulcers than traditional NSAIDs

8

Name the 5 Disease-modifying antirheumatic drugs (DMARDs)?

Quinolones
Glucocorticoids
Sulfasalazine
Methotrexate
Leflunomide

9

Which of the Disease-modifying antirheumatic drugs (DMARDs) is used for both rheumatoid arthritis and SLE?

Quinolones

10

Which of the Disease-modifying antirheumatic drugs (DMARDs) is used for both rheumatoid arthritis and acute gouty arthritis?

Glucocorticoids

11

What is the major side effect of Quinolones?

Retinal damage

12

When patients no longer respond to NSAIDs or can't tolerate other Disease-modifying antirheumatic drugs (DMARDs), which Disease-modifying antirheumatic drugs (DMARDs) is indicated?

Quinolones

13

What is the mechanism for Quinolones?

Reduces T-cell activation and chemotaxis

14

Which Disease-modifying antirheumatic drugs (DMARDs) inhibit phospholipase A2--inhibiting the formation of prostaglandins and also inhibits cytokine production preventing induction of COX-2?

Glucocorticoids

15

What Disease-modifying antirheumatic drugs (DMARDs) inhibits the release of IL-1 and TNF-a?

Sulfasalazine

16

Which Disease-modifying antirheumatic drugs (DMARDs) inhibits aminoimidazolecarboxamide transformylase and thymidylate synthetase and also causes adenosine accumulation inhibiting inflammation?

Methotrexate

17

Which Disease-modifying antirheumatic drugs (DMARDs) inhibits dihydroorotate dehydrogenase, which inhibits T-lympocyte response to stimuli?

Leflunomide

18

Name the major side effects of Glucocorticoids...

Cushingoid symptoms

19

What are the major side effects of Sulfasalazine?

N/V, skin rashes, neutropenia
Headaches can also occur

20

What are the major side effects of Methotrexate?

Nausea, stomatitis, hepatotoxicity

21

What are the major side effects of Leflunomide?

Diarrhea, hepatotoxicity

22

Which Disease-modifying antirheumatic drugs (DMARDs) is considered the gold standard of therapy for Rheumatoid arthritis?

Methotrexate

23

Name the 10 biologic response modifiers used to treat Rheumatoid arthritis...

Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab
Anakinra
Tocilizumab
Rituximab
Abatacept
Tofacitinib

24

Name the 5 Biologic response modifiers that block binding of TNF to TNF receptors to help treat Rheumatoid arthritis...

Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab

25

What is the mechanism of action for Anakinra, used in the treatment of Rheumatoid arthritis?

IL-1 receptor antagonist

26

What is the mechanism of action for Tocilizumab, used in the treatment of Rheumatoid arthritis?

IL-6 Receptor antagonist

27

Which biologic response modifier used to treat rheumatoid arthritis is anti-CD20 mAB reducing the number of circulating B cells?

Rituximab

28

Which biologic response modifier used to treat rheumatoid arthritis inhibits T-cell activation and induces T-cell apoptosis?

Abatacept

29

Which biologic response modifier used to treat rheumatoid arthritis inhibits JAK 1 & 3 inhibiting production of inflammatory mediators?

Tofacitinib

30

What are the side effects seen with Infliximab?

Antigenic response to murine monoclonal Ab

31

What are the side effects seen with Golimumab?

Risk of serious infections

32

What are the side effects seen with Certolizumab?

Risk of serious infections

33

What are the side effects seen with Rituximab?

Infections
Hypersensitivity reactions

34

What are the side effects seen with Adatacept?

Headaches
Infections

35

Where are the side effects seen with Tofacitinib?

Upper respiratory tract infections
Headaches
Diarrhea

36

What drug is used to treat acute gouty arthritis, works within 12-24 hours and prevents tubular polymerization leading to inhibition of leukocyte migration, phagocytosis, and release of cytokines?

Colchicine

37

What are the side effects of long-term use of Colchicine?

peripheral neuropathy and neutropenia

Also can cause N/V, abdominal pain, diarrhea

38

What uricosuric agent is used in the treatment of chronic tophaceous gout?

Probenecid

39

Which drug used in the treatment of chronic tophaceous gout competes with rate at the anionic transport site od the renal tubule and inhibits rate reabsorption?

Probenecid

40

What are the side effects seen with Probenecid?

Urate crystal mobilization and acute gouty arthritis

Also can cause GI irritation

41

What drug reduces uric acid synthesis by inhibiting xanthine oxidase to alloxanthine in treatment of Chronic tophaceous gout?

Allopurinol

42

What are the side effects seen with Allopurinol?

Acute attacks of gouty arthritis early in treatment due to mobilization of rate crystals

43

What drug is a non-purine, non-competitive antagonist of xanthine oxidase used in the treatment of chronic tophaceous gout?

Febuxostat

44

What are the side effects seen with Febuxostat?

Nausea
Rash
Arthralgias

45

A recombinant stabilized fricassee used to convert uric acid to allantoin used in the treatment of chronic tophaceous gout is?

Pegloticase