Rheumatoid Arthritis (RA) Flashcards
1
Q
Define Rheumatoid Arthritis.
A
A systemic, progressive, autoimmune disease that causes chronic arthritis in the peripheral joints which eventually lead to joint deformity.
2
Q
RA causes inflammation which destroys the bone and cartilage due to…
A
proinflammatory cytokines.
3
Q
TNF plays a key role in RA by…
A
stimulating the production of other cytokines which facilitates WBCs to the affected area.
4
Q
In RA, overly active ___ absorb the bone.
A
osteoclasts.
5
Q
What laboratory testing is used to detect RA?
A
Rheumatoid factor (RF); ACCP; ANAs; ESR, CRP; C’.
6
Q
Autoantibodies (usually ___) reacts with the Fc portion of IgG.
A
IgM.
7
Q
Which analyte is highly specific for RA?
A
ACCP.
8
Q
What kind of ANA pattern would be produced in RA?
A
Speckles pattern against RNP.
