Rheumatoid Arthritis Testing Flashcards
1
Q
What happens in rheumatoid arthritis?
A
Autoimmune condition where person creates IgM or IgG antibodies directed at IgG
2
Q
What are the lab findings in rheumatoid arthritis?
A
High titers of rheumatoid factor
Low titers of complement
Positive anti-cyclic citrullinated peptide (anti-CCP)
3
Q
What is the screening test for rheumatoid arthritis?
A
Rheumatoid Factor (RF) assay -- Detects serum IgM
4
Q
What is the confirmatory test for Rheumatoid arthritis?
A
Anti-CCP Assay (Anti-cyclic citrullinated peptide assay)
- Used to confirm positive screening test
- ELISA
- high sensitivity and high specificity
5
Q
Rheumatoid factor (RF) is an anti-immunoglobulin antibody against IgG. What type of antibody is RF?
A
Rheumatoid factors are IgM autoantibodies that are directed against the Fc portion of IgG
