Rheumatology

Question 1

Features of EGPA/Churg

Answer 1

Asthma, allergic rhinitis and eosinophilia
Can get purpuric rash
Rx Pred +/- Cyclophosphamide if cardiac, renal, GI or CNS involved

Question 2

Features of mixed connective tissue disease (9)

Answer 2

Overlap systemic inflammatory disorder
1. Raynauds
2. Swollen hands
3. Arthritis/arthralgia
4. Acrosclerosis (stiffness/tightness of skin)
5. Esopheageal dysmotility
6. Myositis
7. Pulm HTN
8. High anti U1-RNP
9. Anti-snRNP antibodies present

Question 3

Felty’s syndrome?

Answer 3

RA, neutropenia and splenomegaly

Question 4

Features of polyarteritis nodosa

Answer 4

Vague sx include fatigue, weight loss, abdo pain, headache and HTN
Multiple aneurysmal dilatation on mesenteric angiogram
Some link to Hep B

Question 5

Features of microscopic polyangiitis

Answer 5

RPGN + pulm haemorrhage
p-ANCA (MPO)

Question 6

Which infection if Cryoglobuminemia linked to?

Answer 6

Hep C
Commonly leukocytoclastic vasculitis and palpable purpura are presenting sx
Can get GN 20-60%

Question 7

Dermatomyositis

Answer 7

Rash with/preceding muscle weakness
Heliotrope, shawl rash
Mechanics hands

Anti-Mi2 ab
Anti-TIF1 alpha
ANA

Question 8

Inclusion body myositis

Answer 8

Weakness and atrophy of distal muscles
Usually asymmetric involvement