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PLAB 1 FEB 2025 > Rheumatology > Flashcards

Rheumatology Flashcards

(63 cards)

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1
Q

Specific autoantibody for SLE

A

Anti-ds DNA antibody

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2
Q

Sensitive autoAb for SLE

A

ANA

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3
Q

Autoantibody for drug induced lupus

A

Anti histone antibody

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4
Q

Autoantibody for diffuse scleroderma

A

Anti-scl 70

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5
Q

Autoantibody for limited scleroderma

A

Anti centromere

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6
Q

CREST SYNDROME

A

Limited scleroderma
C Calcinosis
R Raynauds phenomenon
E Esophageal dysmotility
S Sclerodactyly
T Telangiectasia

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7
Q

Autoantibody in polymyositis

A

Anti-Jo1

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8
Q

Autoantibody in sjogrens syndrome

A

Anti-Ro
Anti-La

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9
Q

Autoantibody for churg Strauss syndrome

A

P-ANCA

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10
Q

Autoantibody for GPA (WEGENERS)

A

C-ANCA

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11
Q

Autoantibody in Rheumatoid arthritis

A

Rheumatoid factor (initial)
Anti - CCP (most specific)

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12
Q

Autoantibody for celiac disease

A

Anti tissue glutaminase
Anti gliadin
Anti endomysial

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13
Q

Autoantibody for primary biliary cirrhosis and Autoimmune hepatitis

A

Anti mitochondrial
Anti smooth muscle

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14
Q

SLE TREATMENT

A

Hydroxychloroquine
NSAIDS
PREDNISOLONE (SEVERE CASES)
CYCLOPHOSPHAMIDE (LIFE THREATENING LUPUS NEPHRITIS& VASCULITIS)

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15
Q

SLE PRESENTATION (13)

A

1.Low grade Fever
2.Fatigue
3.Mouth ulcers
4.Malar rash (butterfly rash)
5 Photosensitivity(discoid rash)
6.Raynauds phenomenon
7.Arthralgia
8.Myalgia
9.Polyarthritis
10.Libmann sacks endocarditis
11.Pleuritis
12.Pericarditis
13.Glomerulonephritis

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16
Q

C3 and C4 levels in SLE

A

Reduced

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17
Q

Drug induced lupus

A

Hydralazine
Chlorpromazine
Isoniazid

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18
Q

Chronic fatigue syndrome also known as

A

Myalgic encephalitis

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19
Q

Post exertional malaise or
Activity induced muscle fatigue is seen in

A

Chronic fatigue syndrome

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20
Q

Chronic widespread diffuse pain in the joint and muscles
Morning stiffness
Exacerbated in response to pressure

A

Fibromyalgia

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21
Q

Raised serum creatinine kinase with anti jo 1 antibody
Symmetrical Diffuse muscle weakness

A

Polymyositis
Treatment steroids

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22
Q

Raised serum creatinine kinase
ANA
Muscle weakness
Skin manifestations like heliotrope rash,Gottrons papules,shawl sign

A

Deematomyositis

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23
Q

Raised serum creatinine kinase
ANA
Muscle weakness
Skin manifestations like heliotrope rash,
Gottrons papules,shawl sign

A
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24
Q

Heliotrope rash (bluish purple discoloration on the upper eyelids with periorbital edema)seen in

A

Deematomyositis

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25
Gottrons papules (purple red scaly rashes over extensor surfaces of joints and fingers)seen in
Deematomyositis
26
Pain and morning stiffness Difficulty getting out of bed With raised ESR and CRP
Polymyalgia rheumatica
27
Polymyalgia vs myositis
Myositis (weakness > pain) with raised CK Polymyalgia (pain> weakness) with normal CK
28
Giant cell arteritis or temporal arteritis Is a/w
Polymyalgia rheumatica
29
Headache Scalp tenderness Jaw claudication Transient visual field loss
Temporal arteritis Treatment: high dose prednisolone
30
Parotid and lacrimal gland enlargement Dey eyes dry mouth
Sjogrens syndrome
31
Eye drop to treat dry eyes
Hypromellose
32
Abnormal growth of connective tissue Increased fibroblast activity
Systemic sclerosis
33
Thickening of skin Raynauds phenomenon Renal crisis is seen in
Diffuse scleroderma
34
Seronegative spondyloarthritis PAIR B
P PSORIATIC ARTHRITIS A ANKYLOSING SPONDYLITIS I IBD ASSOCIATED ARTHRITIS R REITERS SYNDROME B BEHCETS DISEASE
35
Predominantly involve axial and peripheral joints A/w HLA B27
Seronegative spondyloarthritis
36
Recurrent oral and genital ulcers Anterior or posterior uveitis / retinal vasculitis Pathergy / erythema nodosum
BEHCETS disease
37
Yound males Back pain Morning stiffness Pain improves with activity Anterior uveitis Xray sacrilitis
ANKYLOSING SPONDYLITIS Treatment: Physiotherapy NSAIDS Oral corticosteroids Etanercept and Adalimumab(severe)
38
Can't see Can't pee Can't climb a tree
REITERS arthritis
39
Conjunctivitis Urethritis Arthritis
Reactive / REITERS arthritis
40
M/c/c for reiters syndrome
C. Pneumoniae C. Trachomatis Occurs 2-4 weeks after a GU or GI infection
41
Risk factors for gout
Diet with meat and alcohol Ckd Diuretics Tumour cell lysis (chemotherapy)
42
Treatment for acute gout
NSAIDS Colchicine Corticosteroids
43
Treatment for prevention of gout
Allopurinol Reduces the formation of uric acid
44
Septic arthritis is caused by
S aureus
45
Acute severe joint pain Warmth erythema tenderness and Swelling of joints Limited ROM Fever
Septic arthritis
46
Investigation and treatment of septic arthritis
Joint aspirations and IV antibiotics (flucloxacillin)
47
Bone pain Reduced s. Ca , s. Po4 Increased ALP
Osteomalacia
48
Tenosynovitis of Extensor pollicis brevis And Abductor pollicis longus
De Quervains disease
49
Eosinophilic granulomatosis with polyangitis
Churg Strauss disease
50
PAVE churg Strauss syndrome
P-ANCA ASTHMA VASCULITIS -BIOPSY EOSINOPHILIA INCREASED IGE NASAL POLYPS PURPURA GLOMERULONEPHRITIS
51
Chronic sinusitis Nasal crusting Saddle nose deformity Haemoptysis Dyspnea Epistaxis Hematuria
Granulomatosis with polyangitis
52
Saddle nose deformity Gummas Aneurysm Tabes dorsalis
Neurosyphilis
53
Necrotizing inflammation of the medium sized arteries
Polyarteritis nodosa
54
Mononeuritis multiplex Skin manifestations Abd pain pancreatitis Myalgia arthralgia Headache fever weight loss
Polyarteritis nodosa
55
Rheumatoid arthritis deformity
Swan neck and boutonniere deformity
56
DMARDS
Methotrexate Sulfasalazine Leflunomide Hydroxychloroquine NSAIDS for acute RA and corticosteroids for flares
57
Dry mouth Enlarged parotid and lacrimal gland D/t sarcoidosis tb or lymphoma
Miculicz syndrome
58
Lofgrens syndrome
BHL En Polyarthralgia Fever
59
Lofflers syndrome
Eosinophilic accumulation in lung in response to a parasitic infection
60
Heerfordt syndrome
Uveitis secondary to sarcoidosis Parotid enlargement Fever
61
Ray loves knives
Raynauds phenomenon Treatment Nifedipine
62
Major criteria Rheumatic fever
Subcutaneous nodules Pan carditis Arthritis (polyarthritis) Chorea Erythema marginatum
63
Minor criteria for rheumatic fever
Fever Arthralgia Previous RH or RHD Increased ESR or CRP Prolonged PR interval in ECG

PLAB 1 FEB 2025 (8 decks)

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