RHEUMATOLOGY

Question 1

Sjögren syndrome is an autoimmune _ _ _ _ _ _ _ _ _ _ tissue disorder characterised by _ _ _ _ _ _ _ _ _ _ _ infiltration of _ _ _ _ _ _ _ _ glands

Answer 1

Sjögren syndrome is an autoimmune connective tissue disorder characterised by lymphocytic infiltration of exocrine glands

Question 2

SJOGREN syndrome condition is strongly associated with the human leucocyte antigen HLA- _ _ _

Answer 2

hla-dr3

Question 3

The most common presentation is with “sicca syndrome”. This refers to the classical symptoms of dry _ _ _ _ , dry _ _ _ _ _ and _ _ _ _ _ _ _ _ gland (particularly _ _ _ _ _ _ _ and _ _ _ _ _ _ _ _ gland) enlargement.

Answer 3

the most common presentation being “sicca syndrome”. This refers to the classical symptoms of dry eyes, dry mouth and exocrine gland (particularly parotid and salivary gland) enlargement

Question 4

antibodies in sjogre syndrome

Answer 4

most associated: anti-Ro
others : ANA, RF, anti-La

Question 5

polymyalgia rheumatica

Answer 5

1. on spectrum of giant cell arteritis
2. stiffness and aching of neck, shoulders, back, hip and thigh
3. commonly in elderly

Question 6

Polyarteritis Nodosa features

Answer 6

1. can affect skin , heart, GI and kidneys, brain
2. non specific symptoms like fever, malaise and weight loss
   3.it is a necrotising vasculitis affecting medium sized arteries

Question 7

EPISCLERITIS

Answer 7

1. seen in patients with h/o RA
2. mild pain/discomfort ( lesser than scleritis)
3. sometimes photophobia , vision will be normal

Question 8

SCLERITIS

Answer 8

1. severe boring pain radiating to jaw, forehead, brow

Question 9

POLYMYOSITIS

Answer 9

1.rare inflammatory disorder of skeletal muscles
2.CK will be raised , used to monitor progress of the disease

Question 10

PSEUDOGOUT

Answer 10

1.acute painful seronegative arthritis mimicking gout
2.deposition of calcium pyrophosphate crystals in joints
3.can occur in hypothyroidism, hyperparathyroidism ,

Question 11

cytokines in rheumatoid arthritis

Answer 11

IL 6