Rheumatology

Question 1

Features of Eosinophilic granulomatosis with polyangitis ?
( Churg-Strauss syndrome )

Answer 1

• Asthma - 90% of patients
• Blood eosinophilia
• Paranasal sinusitis / Nasal polyps
• Mononeuritis multiplex
• pANCA positive in 60% of patients
• Pulmonary haemorhages

Question 2

Features of Granulomatosis with polyangitis?

Answer 2

• Upper respiratory tract infection - epistaxis, sinusitis, nasal crusting.
• lower respiratory tract - dyspnea / hemoptysis - caviating leisions
• rapidly progressive glomerulonephritis - pauci - immune
• saddle shaped nose deformity
• vasculitis rash, eye involvement such as proptosis, cranial nerve leisions
• cANCA positive in > 90% of patients, pANCA in 25%
• renal biopsy : epithelial crescents in Bowman’s capsules