Rheumatology Flashcards
(20 cards)
What is the mode of action of rituximab?
B-cell depletor
What rheumatological conditions is rituzimab used to treat?
RA, SLE, CTDs
What is the mode of action of infliximab?
Anti-TNF
What rheumatological conditions is rituzimab used to treat?
RA, PsA, JIA, AS, PsO, Crohn’s, UC
What is the mode of action of tociluzimab?
IL-6 Inhibitor
What is the mode of action of iloprost? What condition is it used to treat?
Vasodilator; Raynauds
What side effects must be observed for with using iloprost?
Hypotension, arrhythmias, headaches and nausea
What is the mode of action of iloprost? What condition is it used to treat?
Ankylating agent (chemotherapy); CTDs
What drug must be given in conjunction with cyclophosphamide?
Mesna (chemoprotectant)
What do the biologics rituximab, infliximab, tociluzimab, iloprost and cyclophosphamide have in common?
They all require infusion
What are the DMARDs commonly used in rheumatological conditions?
Methotrexate, sulfasalazine, hydroxychloroquine and leflunomide
What DSA score constitutes qualifying for bioloigic therapy in RA?
> 5.1
What constitutes qualifying for bioloigic therapy in PsA?
Three sore joints and three swollen joints
What is the BASDAI
Bath Ankylosing Spondylitis Disease Activity Index
What is the Spinal VAS?
Visual Analogue Scale for pain in SpA cases
What qualifies use of biologics in SpA?
BASDAI and Spinal VAS >4
What investigations are required before commencement of biologic therapy?
TB status
Hep B and C
HIV
Vericella/Shingles
List five self-infection biologics available
Entanercept Adalimumab Certolizumab Golimumab Abatacept
What is important about certolizumab?
It is safe during pregnancy
What supplement must be taken if on methotrexate?
Folate
