Rheumatology - guess The Disease

Question 1

Felty syndrome

Answer 1

RA + neutropaenia + splenomegaly

Question 2

Chrondrocalcinosis

Answer 2

Pseudogout

Question 3

% of people with psoriasis who develop PA

Answer 3

20%

Question 4

4 main SE of methotrexate

Answer 4

Pneumonitis
Lung fibrosis
Liver fibrosis
Myelosuppression

Question 5

Pre-check before giving azathioprine

Answer 5

TPMT levels. 1 in 200 have a deficiency that can lead to pancytopaenia

Question 6

Contraception with methotrexate

Answer 6

During and for 3 months after treatment

Question 7

Major drug interaction with methotrexate

Answer 7

Trimethoprim (And co-trimoxazole).

Question 8

What do you co prescribe with methotrexate

Answer 8

Folate

Question 9

Frequency of giving methotrexate

Answer 9

Weekly

Question 10

Guidelines for treatment of new onset RA

Answer 10

Methotrexate
+ 1 other DMARD (e.g. Sulphasalazine)
+ short term prednisolone

Question 11

HLA association of RA

Answer 11

HLA DR4/DR1

Question 12

HLA association with PA

Answer 12

60-70% association with HLAB27

Question 13

SE of colchicine

Answer 13

Diarrhoea

Question 14

Allopurinol drug interaction

Answer 14

Azathioprine + allopurinol –> bone marrow suppression

Question 15

HLA association of ank spond

Answer 15

90% HLAB27

Question 16

6As of ank spond

Answer 16

Aortic regurgitate
Anterior uveitis
AV block
Achilles tendinitis 
Apical lung fibrosis
Amyloidosis

Question 17

Guidelines for bone protection with vit D, calcium and alendronate

Answer 17

If >65 or previous fragility fracture –> treat

If <65 with no fragility fracture –> Do DEXA, if T score

Question 18

1st line treatment for OA

Answer 18

Paracetamol + topical NSAIDs (hand or knee)

Question 19

Complement levels in SLE

Answer 19

C3 and C4 low

Question 20

Main 2 drugs causes drug induced lupus

Answer 20

Procainamide

Isoniazid

Question 21

Pathophysiology of amauroses fugax in giant cell arteritis

Answer 21

Anterior ischaemic optics neuropathy

Question 22

Special features of dermatomyositis

Answer 22

Muscle –> progressive proximal weakness, no pain. Arthralgia.
Skin –> gottron papule, shawl sign, heliotrope rash, nail fold erythema

Question 23

Associated disease with dermatomyositis

Answer 23

Malignancy

Question 24

JIA eye symptoms

Answer 24

Anterior uveitis (like the seronegatives, and unlike RA which is episcleritis and scleritis)

Question 25

Treatment of Raynaud

Answer 25

1st line - CCBs like nifedipine | 2nd line - iloprost IV prostacyclin

Question 26

Marfans mutation and inheritance

Answer 26

AD fibrillin gene

Question 27

Symptoms of pagets diseas of the bone

Answer 27

Only 1 in 20% are symptomatic: Bone pain Tibia bowing Frontal bossing/thickened calvarium

Question 28

Blood tests in pagets

Answer 28

Raised ALP and nothing else

Question 29

Prevalence of pagets

Answer 29

5% (only 1 in 20 are symptomatic)

Question 30

Treatment of pagets

Answer 30

Bisphosphonate

Question 31

Behcets triad + other symptoms

Answer 31

Oral ulcer Genital ulcer Anterior uveitis Others: Thrombophlebitis Arthritis Aseptic meningitis

Question 32

Pethargy test

Answer 32

Pustule formation after small puncture | Behcets

Question 33

Symptoms of osteomalacia

Answer 33

Bone pain Muscle tenderness Proximal myopathy

Question 34

Bloods with osteomalacia

Answer 34

ALP raised | Low calcium, vit D and phosphate

Question 35

X-ray for osteomalacia

Answer 35

Losers zones