Rheumatology - Misc rheumatological conditions Flashcards Preview

Year 4 - SPC > Rheumatology - Misc rheumatological conditions > Flashcards

Flashcards in Rheumatology - Misc rheumatological conditions Deck (47)
Loading flashcards...

What is carpel tunnel syndrome?

Entrapment of the median nerve as it passes under the flexor retinaculum causes carpel tunnel syndrome.

Although it may occur spontaneously, recognised associations include pregnancy, RA, previous wrist injury trauma, hypothyroidism, acromegaly and amyloidosis.

Bilateral disease is relatively common, especially if there is an underlying systemic disorder, although symptoms are usually worse on one side than the other.


What is the presentation of carpel tunnel?

Sensory disturbance (pain and paraesthesia) affecting the radial three and a half digits, worse at night. Some patients report symptoms in the whole hand and extending up the forearm.

Impaired functioning with clumsiness.

Symptoms may be relieved by hanging the arm out of bed at night or shaking the hand.


What are the important findings on physical examination in carpel tunnel syndrome?

Physical examination can be normal, especially if symptoms are intermittent. When present sensory disturbance is evident over the thumb, index and middle fingers, while the ring finger shows a loss of sensation over its radial half.

In long standing cases there may be wasting of and weakness of muscles of the thenar eminence. Two additional clinical tests can be performed that reproduce the patients symptoms:
1) Tinels test - percussion over the median nerve as it passes under the flexor retinaculum

2) Phalen's test - wrist is maintained in a fixed flexion position


How should carpel tunnel syndrome be investigated?

Nerve conduction studies - confirm compression of the median nerve at the wrist.

Perform investigation of underlying cause as indicated clinically.


How should carpel tunnel syndrome be managed?

Treatment is indicated by the severity of the condition but may involve:
- splinting of the wrists at night
- injection of corticosteroids
- surgical decompression of the flexor retinaculum


What is the prognosis of carpel tunnel syndrome?

Complete resolution of symptoms is usually achieved except in the most long standing cases when permanent nerve damage has occurred.


What patients are at risk of septic arthritis?

Septic arthritis can occur in patients of any age or gender, but it is more common in the very young, the very old those with pre-existing abnormal/ damaged joints, immunocompromised individuals and IVDUs.


How do bacteria infect the joint in septic arthritis?

1) Direct innoculation - e.g. penetrating injury, joint injection or surgery

2) Haematogenous spread during an episode of bacteraemia

3) Spread from neighbouring soft tissues (cellulitis) or bone (osteomyelitis) infection


What agents are commonly implicated in septic arthritis?

Staph aureus
Beta haemolytic strep
Gram negative bacilli (e.g. E coli, Pseudomonas)
Neisseria gonorrhoea


What is the clinical presentation of septic arthritis?

Sudden painful/ swollen joint in the context of pre-existing infection or in a patient with otherwise quiescent chronic joint disease should be assumed to be septic arthritis until proven otherwise.

Usually a single joint infection is most common (most commonly the knee) but several sites may be involved. Septic joints are very painful and are often held immobile to minimise discomfort. Systemic upset with pyrexia +/- rigors is common, but occasionally the patient may appear well.

Gonococcal infection may present with polyarthralgia and a migratory arthritis, associated with a purpuric rash - clinically apparent genital infection is not always apparent.


How should septic arthritis be investigated?

Joint aspiration: joint fluid is turbid and microscopy excludes crystal arthropathy, a Gram stain may confirm the presence of bacteria, and the fluid can be sent for MC&S

FBC: leucocytosis is common and the ESR and CRP are raised

Blood cultures: may confirm a bacteraemia and identify the organism

Radiology: narrowing of the joint space signifies destruction of the cartilage


How is septic arthritis managed?

Antibiotics should be started following joint aspiration and the ideal agent should cover the most common organisms, i.e. staphylococcus aureus and beta haemolytic strep. Flucloxacillin i.v. (erythromycin or clindamycin if penicillin allergic) and oral fusidic acid 500mg 8 hourly is the preferred combination. Gentamicin is added to immunosuppressed patients to cover gram negatives. Treatment should be modified depending on culture and sensitivity and continue with two antibiotics for 6 weeks (initial 2 weeks IV) and a single antibiotic for a further 6 weeks.

Immobilise joint in early stages, mobilise early to avoid contractures.

NSAIDs for pain relief.


What is a frozen shoulder? How does it present?

This is a relatively common and potentially disabling condition affecting 1-2% of the middle aged and elderly population. For reasons that are unclear, the joint capsule becomes adherent to the overlying rotator cuff muscles.

It is typically unilateral and characterised by progressive pain and reduced mobility. Untreated, improvement with time is generally the rule but may take up to 2 years. Intra-articular injection of corticosteroid may help ease the pain and should be combined with regular exercise to restore movement.


What is rotator cuff tendonitis?

Repetitive or unaccustomed movements of the shoulders may result in inflammation of one or more of the rotator cuff muscles tendons. Pain during abduction, flexion or rotation of the shoulder is often accompanied by point tenderness. Plain radiographs may show tendon calcification, but ultrasound or MRI will demonstrate oedema with tears within the tendon. Treatment options include NSAIDs, physiotherapy, local injection or corticosteroids and surgery.


What is rotator cuff degeneration?

This is commonly seen in elderly patients who have restricted shoulder movements in all directions which limit activities of daily living. Local injection of corticosteroids may tried, but the underlying pathological process tends to be progressive.


What back problems are common in younger patients (i.e. 15-30)?

The age of the patient helps in deciding the aetiology of back pain because certain causes are more common in particular age groups.

Mechanical, prolapsed intervertebral disc, ankylosing spondylitis, and spondylolithesis are all common in this age group.


How does mechanical back pain present?

Mechanical causes of back pain include lumbar disc prolapse, osteoarthritis, fractures, spondylolithesis and spinal stenosis.

Pain is often of sudden onset and worse in the evening. Morning stiffness is absent and exercise aggravates the pain.


What back problems are common in middle aged patients (i.e. 30-50)?

Prolapsed intervertebral disc
Degenerative joint disease
Fractures (all ages)
Infective lesions (all ages)


How does inflammatory causes of back pain present?

The main inflammatory cause of back pain is Ankylosing spondylitis and infection.

Pain is usually of gradual onset and is worse in the morning. Morning stiffness is also present. Exercise relieves the pain.


What are the red flag symptoms of back pain?

Age <20 or >50 years
Constant pain without relief
History of TB, HIV, carcinoma, steroid use
Systemically unwell; fever; weight loss
Localised bone tenderness
Bilateral signs in the legs
Neurological deficit involving more than one root level
Bladder, bowel or sexual function deficits


What causes of back pain are common in the elderly?

Degenerative joint disease
Pagets disease


How should back pain be investigated?

The key points are age, speed of onset, the presence of motor and sensory symptoms, involvement of the bladder or bowel and the presence of stiffness and the effect of exercise. Young adults with a history suggestive of mechanical back pain and with no physical signs do not need further investigation.

FBC, ESR and serum biochemistry (calciu, phosphate, ALP) are required only when the pain is likely to be due to malignancy, infection or metabolic bone disease. PSA should be checked if secondary prostatic disease is suspected.

Spinal X rays are only indicated if there are "red flag" symptoms and signs which indicate the high risk of more serious underlying problems.

Bone scans show increased uptake with infection or malignancy.

MRI is useful when neurological symptoms are present. It is useful for detection of discs and cord lesions. CT scans demonstrate bone pathology better.


What is acute disc disease?

Prolapse of the intervertebral disc results in acute back pain (lumbago), with or without radiation of the pain to areas supplied by the sciatic nerve. It is a disease of younger people (20-40 years) because the disc degenerates with age and in elderly people is no longer capable of prolapse. In older patients sciatica is more likely to be the result of compression of the nerve root by oesteophytes in the lateral recess of the spinal canal.


What are the clinical features of acute disc prolapse?

There is sudden onset of severe back pain, often following a strenuous activity. The pain is often clearly related to position and is aggravated by movement. Muscle spasm leads to sideways tilt when standing. The radiation of the pain and the clinical findings depend on the disc affected.


What are the features of an S1 root lesion?

Pain is from the buttock down the back of the thigh and leg to the ankle and foot.

Sensory loss is on the sole of the foot and posterior calf. Plantar flexion of the ankle and toes is lost and the ankle jerk reflex (S1 S2) is affected. There may also be diminished straight leg raise.


What are the features of an L5 root lesion?

Pain is from the buttock to the lateral aspect of the leg and dorsum of the foot.

Sensory loss is along the dorsum of the foot and anterolateral aspect of the lower leg.

Dorsiflexion of the foot and toes are affected but there is no reflex lost at this level. There may be diminished straight leg raise as with an S1 lesion.


What are the features of an L4 root lesion?

Pain on the lateral aspect of the thigh to the medial side of the calf.

Sensory loss is over the medial aspect of calf and shin. Motor weakness is in dorsiflexion and inversion of ankle; extension of the knee.

Knee jerk reflex is lost.


How should acute disc disease be investigated?

Investigations are of very limited value in acute disc disease and X rays are often normal. MRI is usually reserved for patients in whom surgery is being considered.


How should acute disc disease be managed?

Treatment is aimed at the relief of symptoms and has little effect on the duration of the disease. In the acute stage, treatment consists of bed rest on a firm mattress, analgesia and occasionally epidural corticosteroid injection in severe disease. Surgery is only considered for severe or increasing neurological impairment - e.g. foot drop or bladder symptoms. Physiotherapy is used in the recovery phase, helping to correct posture and restore movement.


What causes chronic disc disease?

Chronic lower back pain is associated with "degenerative" changes in the lower lumbar discs and facet joints. Pain is usually of the mechanical type. Sciatic radiation may occur with pain in the buttocks radiating into the posterior thigh. Usually the pain is long standing and the prospects of cure are limited. Weight loss, NSAIDs and physiotherapy are all useful measures.

Surgery can be considered when pain arises from an identifiable level and has failed to respond to conservative measures, and fusion at this level, with decompression of the nerve roots, can be successful.