Rheumatology: Osteoarthritis, Crystal Arthropathies, Soft tissue Rheumatism Flashcards

(63 cards)

1
Q

What is Osteoarthritis typically described as?

A

“wear and tear” of the joints

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2
Q

What are the risk factors for developing osteoarthritis?

A

Age, muscle weakness, occupation, genetic elements, sports, previous injuries

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3
Q

What is the link between osteoarthritis and osteoporosis?

A

Can’t have both, osteoporosis protects against osteoarthritis

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4
Q

What can be seen on an osteoarthritis X-ray?

A
LOSS
Loss of joint space
Oesteophytes
Sclerosis
Subchondral cysts
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5
Q

What are osteophytes?

A

Bone spurs with jagged edges

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6
Q

What happens in subchondral cysts?

A

Synovial fluid flows into breaks in the cartilage

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7
Q

What are factors which contribute to development of osteoarthritis?

A

Complex interplay of many factors: genetic, joint integrity, mechanical force and cellular and biochemical forces

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8
Q

Who is commonly affected by osteoarthritis?

A

1/3rd of population over age of 45, 1/2 population over 70

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9
Q

What are the different types of osteoarthritis?

A

Idiopathic or Secondary

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10
Q

What can Idiopathic osteoarthritis be further divided into?

A

Localised (1 site) or generalised (3 or more sites)

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11
Q

What can cause secondary osteoarthritis?

A

Previous injury, genetic elements, rheumatoid arthritis, agromegally, calcium crystal deposition

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12
Q

What is the typical clinical presentation of osteoarthritis?

A

Pain, worse of activity and relieved by rest

Stiffness in morning lasting

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13
Q

What can be seen on examination is osteoarthritis?

A

Crepitus, swelling (bony enlargements due to osteophytes), Heberden’s nodes and Bouchard’s nodes

Later stages: joint tenderness and effusion

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14
Q

What joints can be affected by osteoarthritis?

A

All weight baring joints of lower limb: hip, knee, ankle, tarsal, metatarsals
Hands, arms and spine

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15
Q

What clinical features can be seen on the knee in osteoarthritis?

A

Baker’s cyst, gene varus, gene valgus

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16
Q

What is gene varus and what is it seen as clinically?

A

Knee moving towards the midline, seen as bow legged clinically

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17
Q

What is gene valgus and what is it seen as clinically?

A

Knee moving away from the midline, seen as knock-kneed clinically

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18
Q

What can be seen on the hands on examination in osteoarthritis?

A

Bouchard’s nodes and Heberden’s nodes and squaring of the thumbs

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19
Q

How is the spine affected in osteoarthritis?

A
  • Mainly facet joints affected
  • Osteophytes may compress the nerve roots
  • Cervical area affected causes restriction of movement and pain
  • Osteophytes at lumbar region can cause spinal stenosis, and if encroaches on spinal canal can cause problems with walking, spinal claudication
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20
Q

How can hip pain be felt in osteoarthritis?

A

As pain radiating to the knee or groin

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21
Q

What is the natural history of progression of osteoarthritis in the hands?

A

Over a 2 year period, pain often improves although swelling becomes more marked

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22
Q

What is the natural history of progression of osteoarthritis in the knee?

A

1/3 of patients’ symptoms improve, 1/3 are stable and 1/3 deteriorate

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23
Q

What is the natural history of progression of osteoarthritis in the hip?

A

10% come off the surgical waiting list as symptoms improve

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24
Q

What are the non pharmacological interventions in osteoarthritis?

A

Explanation, physiotherapy and “common sense measures” such as weight loss, walking stick and exercise

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25
What are the surgical interventions in osteoarthritis?
- Best treatment is joint replacement if there are no other co-morbidities - Arthroscopic washout is plan B which involves soft tissue trimming
26
What are the pharmacological interventions in osteoarthritis?
- Analgesia eg ibuprofen, paracetomol for pain - NSAIDs - Temporary solution: inject steroid into joints
27
When should NSAIDs be avoided?
- In patients with renal impairment - Angina - Increased risk of peptic ulcer disease
28
What grading scale is used to chart osteoarthritis?
Kellegren-Lawrence Radiographic Grading Scale, grades 0-4
29
What is gout?
Inflammation of the join triggered by uric acid crystals
30
At what level does uric acid become insoluble?
>0.42mmol
31
What causes the imbalance of uric acid production?
- Excess consumption - Over production - Under excretion
32
What factors can cause decreased urate excretion?
Hypothyroidism, cytotoxics, volume depletion by heart failure, Thiazide diuretics, chronic renal impairment
33
What factors can cause increased urate production?
inherited enzyme defects, psoriasis, haemolytic disorder, alcohol, high dietary intake
34
Who is commonly affected by gout?
- Rare before the age of menopause | - Obesity and adverse dietary factors increase risk
35
Where is the most commonly affected areas in acute gout?
Most common= big toe followed by ankle and knee
36
How long does it take for acute gout to settle?
About 3 days with treatment and 10 days without
37
How does acute gout present?
Abruptly, often overnight
38
How will uric acid level be at acute presentation of gout?
Probably normal
39
What drug is chronic gout often associated with?
Diuretics
40
What constitutes chronic gout?
More than 4 joints affected at one given time
41
What are the investigations for gout?
- 10% of people have high uric acid level - Raised inflammatory markers - Polarising microscopy of synovial fluid - x ray
42
What should you look for in an X-ray of gout?
Dense shadow which extends across the joint
43
What is the treatment of acute gout?
1 of the following: - NSAIDs - Colchicine - Steriods
44
What is the prophylaxis of gout?
-Allopurinol or Febuxostat
45
How long should you wait after an acute attack of gout before prescribing prophylaxis?
2-4 weeks
46
What does Chronic Tophaceous Gout present as?
Hard nodular mass
47
What is pseudo gout?
Increased calcium pyrophosphate crystals
48
Who does pseudo gout typically affect?
The elderly
49
Why does pseudo gout affect the elderly?
Chondrocalcinousis increases with age
50
What does pseudo gout affect?
The fibrocartilage, most commonly the knees and wrists
51
How is pseudo gout diagnosed?
By polymicroscopy
52
What is the treatment for pseudo gout?
Similar to gout: NSAIDs, colchicine, steriods, rehydration
53
Who does joint hyper mobility syndrome typically affect and who does it arise?
females in childhood or in 30s, can be caused by rare genetic syndrome such as Marfan's or Ehler's
54
What is soft tissue rheumatism?
General term used to describe pain that is caused by inflammation/damage to ligaments, tendons, muscles or nerves near a joint rather than the actual bone or cartilage
55
How does soft tissue rheumatism typically present?
Localised to one side e.g. shoulder, wrist
56
Give examples of soft tissue rheumatism of the foot, wrist, elbow..
Foot= plantar fasciitis Wrist= carpal tunnel Elbow: Cubital tunnel
57
Where is the most commonly affected area in soft tissue rheumatism?
Shoulder and neck
58
What is Hydroxyapatile?
Deposition of hydroxyapatite crystals in or around the joint
59
What is "Milwankee shoulder"?
Another name for Hydroxyapatile which is deposition of hydroxyapatite crystals in or around the joint
60
Who does Hydroxyapatile most commonly affect?
Females 50-60yrs
61
What is the treatment for Hydroxyapatile?
NSAIDs, intra-articular steriod injection, physiotherapy
62
How does Hydroxyapatile arise?
Deposition of hydroxyapatite crystals in or around the joint causes the release of collagenases, serine proteinases and Il-1 which causes acute and rapid decline in joint function and degradation of joint anatomy
63
What is the onset of symptoms of Hydroxyapatile?
Acute and rapid deterioration