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I And I Final > RNA + Viruses > Flashcards

RNA + Viruses Flashcards

(70 cards)

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1
Q

Pico virus sketchy scene

A

Peak orna animal nursery

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2
Q

Naked, icosahedral, +ssDNA, small

A

Pico

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3
Q

All + sense get replicated

A

In cytoplasm

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4
Q

Polio transmission

A

Resp and fecal/oral

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5
Q

Polio can cross

A

BBB

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6
Q

Infects axons of peripheral nerves and attacks anterior horn of spinal cord

A

Polio

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7
Q

Most kids with _____ are asymptomatic

A

Polio

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8
Q

What percent of polio is severe

A

1-2

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9
Q

Paralysis of diaphragm

A

Polio

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10
Q

What are all the enteroviruses

A

Polio
Coxsackie
Echovirus
Enterovirus

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11
Q

Enteroviruses are stable at _____ pH

A

Acidic

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12
Q

Enteroviruses replicate in

A

Oropharynx and GI tract

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13
Q

Enterovirus 71 causes

A

Hand foot and mouth
Poliomyelitis
Not really in USA

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14
Q

Enterovirus D68 causes

A

Acute flaccid myelitis
a resp illness comes before this

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15
Q

Encephalomyocarditis syndrome

A

Coxsackie B1 virus

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16
Q

Acid labile +

A

Rhino

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17
Q

Major trigger of asthma exacerbations and development of childhood asthma

A

Rhino

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18
Q

How does hep A transmit

A

Contaminated food
Fecal oral - daycares
IV drug use - #1 in USA

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19
Q

Jaundice, abnormal liver enzymes, fever, fatigue, nausea, abdominal discomfort

A

Hep A

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20
Q

Leading cause of viral gastroenteritis over all age groups

A

Norovirus - caliciviridae

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21
Q

Food preparer who is no longer symptomatic can still transmit virus

A

Norovirus

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22
Q

Low infectious dose, naked, fecal/oral transmission, common in daycares

A

Norovirus

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23
Q

Enveloped, iscosahedaral, arbovirus

A

Flaviviridae

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24
Q

If you have an antibody for yellow fever what could you also be protected agains

A

Dengue
Yellow
Zika
WN
Japanese encephalitis
St. Louis encephalitis
Powassan

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25
What are the primary targets for flaviviridae
Cells of monocyte and macrophage lineage Also dendritic cells
26
May infect endothelial cells of capillaries, has glycoproteins E1 and E2
Flavivir
27
Breakbone fever
Dengue
28
Worldwide, especially tropics
Dengue
29
Africa, South America
Yellow fever
30
Zika
Worldwide, especially tropics
31
Asia
Japanese encephalitis
32
Africa, Europe, Central Asia, North America
West nile
33
North America
St. Louis encephalitis And Powassan encephalitis
34
Sylvatic vs urban
S = wooded areas primate —> mosquito—>human U = human—>mosquito—>human
35
Gets midgut of ____ and moves to their ____ glands
Mosquito Salivary
36
Arboviruses are picked up through the ___ but spread through ____
Blood Saliva
37
With arbovirus, if virus is not cleared after primary viremia what can happen
Secondary viremia can produce enough virus to infect other organs
38
Mild affects of arbovirus primary viremia
Fever, chills, headaches, arthralgias
39
Effects of secondary arbovirus viremia
Hemorrhagic feve Shock Encephalitis
40
Assembly and release of HCV
HCV and VLDL form lipo viral particle The viral antigens in LVP are shielded form immune response
41
Flushed skin, red conjunctiva, hepatomegaly
YFV
42
Yellow fever presentation
Infection—>remission—>intoxication—>death
43
Intoxication YFV
High fever Coagulopathy and hemorrhaging Hepatic is wack/jaundice Renal failure Shock
44
If you’re going to Africa or South America what should you get
YFV live vax
45
Retro-orbital pain
Dengue
46
Describe the antibody - dependent enhancement Which disease
Dengue 1st infection: our body makes Ab to the infecting subtype 2nd infection: the 1Ab can cross react and bind to the 2nd infecting subtype. This enhances the uptake of the virus bc the virus has FC receptor
47
Why can Zika be scary
Congenital Zika = microencephaly Guillain barre
48
Chronic inflammatory demyelinating polyneuropathy
Zika
49
What are the encephalitis viruses
West Nile, St. Louis, Powassan
50
Presentations of encephalitis viruses
Non-neuroinvasive Neuroinvasive
51
Intermediate host for MERS
Camels
52
Largest RNA virus
Coronavirus
53
What binds to ACE2
Spike protein
54
Vax for sars cov2 induces antibodies to what
Spike protein
55
MERS transmission
Person to person Doesn’t spread well
56
Which is more pathogenic SARSCOV or SARSCOV2
SARSCOV
57
Why is SARSCOV2 more widespread and severe
Bc its less virulent so its harder to detect, people spread it easier Mutates quick
58
ARDS = ___ From what disease
Acute respiratory distress syndrome Covid
59
When do viral titers peak in covid
4 days after onset
60
Describe Multisystem inflammatory syndrome what is it from
Cytokine storm like heart, and kidney stuff COVID
61
SARS COV2 is huge so it has its own
Proofreading system
62
Explain the variants of COV2
1: RNA polymerases make a lot of mistakes 2: recombination happens 3: this might change pathogenicity 4: which might make it easier to escape immune response If we get OG variant our body makes Ab for OG. If we then get delta variant we do not already have the Ab for it
63
Things in α genus of toga
EEEV WEEV VEEV Chikungunya
64
Toga altered pattern
+ RNA —> nonstructural proteins encoded in 5’ end of genomic RNA —-> - strand—-> subgenomic + mRNA from 3’ end——> structural proteins
65
α virus that’s north & South America and Caribbean
EEEV
66
α virus that’s North & South America
WEEV
67
α virus that’s north, south and Central America
VEEV
68
α virus that’s africa and Asia
Chikungunya
69
Which α virus causes severe encephalitis
VEEV
70
Severity of congenital rubella depends on
Fetal age at time of viremia Major risk up until 20th week of pregnancy

I And I Final (5 decks)

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