Road from discovery to clinical implementation of protein biomarkers for neurodegenerative diseases Flashcards
1
Q
What is the value of biomarkers?
A
- indicator of a particular disease state or some physiological state of an organism
- increases diagnostic accuracy
- predicts what happens
- treatment monitoring
2
Q
What makes an ideal biomarker? (4)
A
- easily accessible
- disease specific
- not influences by other factors
- reflecting pathology/clinical correlate
3
Q
How is dementia currently diagnosed?
A
- cognitive and neuropsychological tests
- neurological evaluation
psychological evaluation - brain scans (CT, MRI, PET)
- laboratory tests
4
Q
What should a biomarker for dementia enable?
A
- early diagnosis
- prognosis
- monitoring
5
Q
How long can the process from discovery to implementation of a biomarker last?
A
up to 20 years
6
Q
What is a challenge in the translation of biomarker identification (phase 1) into test development (phase 2) in the biomarker development?
A
challenge - the translation of discovered findings onto a scalable assay
7
Q
What Alzheimers disease biomarkers can be detected currently in CSF?
A
AB42 decreases
p-tau increases
t-tau increases
