Robbins Chapter 13 - WBC Morphology Flashcards Preview

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Flashcards in Robbins Chapter 13 - WBC Morphology Deck (7)
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Morphologic changes in neutrophils that often accompany leukocytosis .

Toxic granulations, Dohle bodies (dilated ER) , cytoplasmic vacuoles


What is this describing -
Nodes are (painful) swollen, gray-red, and engorged. Large reactive germinal centers with numerous mitotic figures. Macrophages often contain particulate debris derived from dead bacteria or necrotic cells.

Acute Nonspecific Lymphadenitis


The name of the macrophages containing nuclear debris of B cells that are interspersed between the germinal B centers.

Tingible body macrophages


A person has one of these three things - Rheumatoid arthritis, toxoplasmosis, early HIV.
What type of hyperplasia are these stimuli for?

Three stimuli that cause Follicular Hyperplasia - round, oblong germinal centers surrounded by collar of small resting naive B cells (mantle zone)


Name the type of hyperplasia-
1. Dark zone containing proliferating blastlike B cells (centroblasts)
2. Light zone containing B cells with irregular or cleaved nuclear contours

Follicular hyperplasia - a reactive follicle surrounding mantle zone


A person has a viral infection (i.e. infectious mono) - what type of hyperplasia is this a stimulus for?

Stimulus for T-cell mediated immune responses that cause Paracortical Hyperplasia (expanded T-cell zones)


Name the type of hyperplasia - increased number and size of cells that line the lymphatic sinusoids. Lining lymphatic endothelial cells is markedly hypertrophied and macrophages increased = expansion and distension of sinuses.
Possible in nodes draining cancers (i.e. breast cancer)

Sinus histiocytosis (reticular hyperplasia)