ROCA Sept 2018 Flashcards
(43 cards)
a) What factors determine the intraocular pressure in a healthy eye?
- Arterial blood pressure
- Venous pressure
- Partial pressures of PO2 and PaCO2
- Partial pressures
b) What key points would you need to know when assessing this patient preoperatively?
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1. Fasting time
- RTA - cause? Medical cause underlying crash
ECG - Other injuries
Any life threatening injuries that require Rx prior to eye - Airway assessment
- Other significant PMH / Prev anaesthetic
C. The patient requires urgent surgery. Discuss your specific intraoperative management.
.
d) What contraindications are there to performing a regional block in elective ophthalmic surgery?
.
e) What different types of regional block are suitable for ophthalmic surgery?
.
a) List the postoperative pulmonary complications that may occur following non-cardiothoracic surgery
Atelectasis Pneumonia Respiratory failure Pleural effusion Pneumothorax Bronchospasm Aspiration pneumonitis
b) What are the patient related risk factors for postoperative pulmonary complications following non cardiothoracic surgery?
Age >60 years (good) (good)
American college of anaesthesiologists II or more (good)
Functional dependency (good) Congestive heart failure (good) Chronic obstructive pulmonary disease (good)
Smoking (fair)
Recent upper respiratory tract infection (fair)
Pulmonary hypertension (fair)
Delirium (fair)
Alcohol use (fair)
Weight loss >10% (fair)
Disseminated cancer (fair)
b Surgery related risk factors for postoperative pulmonary complications following non cardiothoracic surgery?
Prolonged surgery (>3 h)
Surgical site: Abdominal, thoracic, neurosurgery, vascular, head and neck surgery (good)
Emergency surgery (good)
c) How might anaesthesia contribute to postoperative pulmonary complications?
- General > Regional
The combination of general anaesthesia, supine
positioning, opiates, and residual neuromuscular block reduces lung volumes and causes atelectasis in a spontaneously ventilating patient.
Poor use of Neuromuscular blocking agents (NMBAs), by failure to monitor correctly or excessive dosing, is associated with an increased risk of PPC
Anaesthetic agents diminish respiratory drive and the response to hypoxia and hypercapnia, resulting in hypoventilation. In a spontaneously ventilating patient, the closing capacity approaches FRC and the small airways collapse causing atelectasis in the dependent regions of the lung.
Hypoxaemia can result from ventilation–perfusion mismatching and increased shunt fraction. Prolonged periods of 100% oxygen may produce absorption atelectasis as all the oxygen is absorbed and the
splinting effect of nitrogen in the alveoli is lost.
Inadequate analgesia
The
effects of anaesthesia, bed rest, and opioids inhibit the cough
reflex and impair respiratory tract ciliary activity, while dry
gases result in mucus plugging. These physiological effects contribute to the development of PPCs.
What perioperative strategies may you adopt to reduce postoperative pulmonary complications?
Preoperative
Optimization of existing cardiorespiratory disease (fair)
Early smoking cessation (fair)
Prehabilitation exercise programmes (insufficient data)
Intraoperative:
Minimally invasive surgical Techniques (fair)
Lung-protective ventilationvstrategies (fair)
Selective use of nasogastric tubes (good)
Short acting NMBAs with quantitative monitoring
(fair)
Neuraxial blockade (insufficient data) Goal-directed fluid therapy (insufficient data)
Postoperative Adequate analgesia (good) Early mobilization (good) Postoperative epidural analgesia (insufficient) Lung expansion techniques (good)
What is Guillain–Barré?
What is Guillain–Barré?
» Acute, immune-mediated, pre-junctional, ascending demyelinating
polyneuropathy affecting sensory, motor and autonomic nerves.
What are causes of Guillain Barre?
> > Associated with respiratory
or gastrointestinal infection
(especially Campylobacter) in preceding weeks.
> > Autoimmune in nature –
antibodies attack the myelin sheath
or, more rarely, the axon itself.
b) What are the clinical features of Guillain–Barré syndrome? (6 marks)
1 Variable presentation depending on subtype;
different forms associated with immune attack on different parts of the neurone.
Recovery is variable,
ranging from full recovery
to relapsing, remitting form.
2 >> Motor: typically ascending symmetrical weakness (flaccid, areflexic paralysis), may ascend to involve respiratory muscles and also to cause facial nerve palsies with bulbar weakness and opthalmoplegia.
> > Sensory:
ascending sensory impairment
associated with pain.
> > Autonomic: arrhythmias,
labile BP, urinary retention,
paralytic ileus,
hyperhydrosis, sudden death.
> > Miller Fisher syndrome:
this is a variant typified by ataxia, areflexia,
opthalmoplegia +/− weakness.
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Airway:
» Bulbar weakness,
poor cough, increased risk of aspiration.
Intubation required – consider need for rapid sequence induction.
> > May still have tracheostomy in situ
if still requiring ventilatory support or
assistance with secretion clearance.
Respiratory:
» Increased risk of pneumonia
secondary to aspiration and poor ventilatory
function. Make full assessment of this – history, nature of secretions, temperature, chest auscultation. Treat as required, delay non-urgent surgery if necessary.
> > Significantly reduced ventilatory capacity,
assess likelihood of requiring
noninvasive or invasive ventilation postoperatively.
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Cardiovascular:
» Autonomic instability, labile BP (with sensitivity to commonly used vasoactive drugs),
risk of arrhythmia.
Invasive monitoring indicated including cardiac output monitoring to guide fluid administration (ensure
full circulation as dehydration will exacerbate lability).
> > Prolonged illness,
multiple cannulations, access may be tricky.
Neurological:
» Neuropathic pain common –
may already be on antineuropathic drugs
+/− opioid analgesia.
Need to plan postoperative pain relief,
involve acute Cardiovascular:
» Autonomic instability, labile BP (with sensitivity to commonly used
vasoactive drugs), risk of arrhythmia. Invasive monitoring indicated
including cardiac output monitoring to guide fluid administration (ensure
full circulation as dehydration will exacerbate lability).
» Prolonged illness, multiple cannulations, access may be tricky.
Neurological:
» Neuropathic pain common – may already be on antineuropathic drugs
+/− opioid analgesia. Need to plan postoperative pain relief, involve acute
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Pharmacology:
» Suxamethonium: contraindicated due to risk of hyperkalaemia following
the development of extrajunctional nicotinic receptors.
> > Non-depolarising neuromuscular blocking agents: increased sensitivity – reduce dose.
> > Opioids: increased sensitivity to respiratory depressant effect in the presence of existing respiratory compromise, may already be taking
opioids and so dose adjustments may be necessary.
d) What are the specific considerations when anaesthetising a patient recovering from Guillain–Barré syndrome?
Haematology:
» Risk of deep vein thrombosis due to prolonged immobility – continuation
of thromboembolic deterrent stockings and pneumatic compression
devices and pharmacological prophylaxis (check timing if planning
neuraxial technique).
Cutaneomusculoskeletal:
» Prolonged illness may be associated with weight loss – care with positioning and padding.
Renal:
» Check renal function – may dictate drug choices.
What investigations are useful in GBS
Blood tests:
» Variable, not specific or sensitive: low sodium, renal dysfunction, raised
ALT and GGT raised CK.
» Elevated ESR +/− CRP.
» Antiganglioside antibodies (antibodies against a component of the axon
itself, increased association with Campylobacter, worse prognosis) in 25%.
> > Serology for Campylobacter, CMV, EBV, HSV or Mycoplasma pneumoniae
may be positive.
ABG may show development of respiratory failure.
Stool:
GI infections, especially Campylobacter.
CT brain:
Normal: to exclude other causes.
MRI spine:
Selective anterior spinal nerve root enhancement with gadolinium.
Lumbar puncture:
Normal cell count and glucose, elevated protein levels (although even this
may be normal early in the disease).
Nerve conduction studies:
Depends on subtype: majority show demyelinating pattern, some show
axonal loss.
Respiratory function tests:
Reduced vital capacity.
Specific Rx for GBS
- IVIG
2. PLEX
a) Which investigations are specifically indicated in the
preoperative assessment of a patient presenting for
thyroidectomy for treated thyrotoxicosis? (5 marks)
- Blood tests:
» Thyroid function tests:
confirm that the patient is euthyroid.
> > Full blood count:
carbimazole and propylthiouracil can cause
agranulocytosis. Check haemoglobin is adequate.
> > Two group and save samples:
potential for blood loss.
> > Calcium: check preoperatively as level may drop postoperatively due to loss of parathyroid glands.
ECG:
» Should show normal rate if euthyroid.
May be bradycardic if ongoing beta
blocker use.
Fibreoptic nasendoscopy:
» If concerns about likely ease of visualisation of larynx at laryngoscopy.
CXR or lateral thoracic inlet film:
» May indicate tracheal deviation or narrowing.
CT:
» Assess for retrosternal extension of goitre, tracheal compression.
b) What particular issues must the anaesthetist consider during the induction, maintenance and extubation phases of anaesthesia for a euthyroid patient having a total thyroidectomy? (11 marks)
Induction:
» Possibility of deterioration in tracheal compression on lying flat if large goitre (although this should have been elicited by preoperative questioning and investigations).
Head-up tilt for induction. Consider need
for smaller-diameter endotracheal tube.
> > Possibility of slower than usual intubation,
if difficult, and, therefore, hypoxia.
Pre-oxygenation required; consider use of high-flow nasal oxygen.
> > Choice of airway management is determined by preoperative investigations and discussion with the surgeon: straightforward intubation, asleep or awake fibreoptic intubation, awake tracheostomy.
Full difficult airway kit should be ready.
» Shared airway: armoured tube.
» If ‘can’t intubate, can’t ventilate’ (CICO) situation is encountered due to goitre size, obstruction is likely below the level of a cricothyroidotomy:
ENT surgeon ready for rigid bronchoscopy
b) What particular issues must the anaesthetist consider during the induction, maintenance and extubation phases of anaesthesia for a euthyroid patient having a total thyroidectomy? (11 marks)
Maintenance:
» Shared airway surgery, patient’s head distant to anaesthetist:
- Padding of eyes (extra care if exophthalmos).
- Secure taping of tube.
- Be alert to airway dislodgement or tube compression.
• Head-up tilt to improve venous drainage but not so as to impair arterial supply
.
• Extensions on fluid administration set.
• Long breathing circuit for anaesthetic machine.
> > Drugs:
• Maintenance via intravenous or inhalational route.
- Remifentanil useful to minimise need for further muscle relaxant and to achieve a degree of hypotension that will improve surgical field.
- Vasopressor, e.g. phenylephrine, may be useful to achieve normotension towards the end of surgery to test haemostasis.
- High risk of nausea and vomiting: give antiemetics.
Dexamethasone has added effect of reducing airway oedema.
• Plan for postoperative analgesia: important for blood pressure control postoperatively. Intravenous morphine towards end of surgery, regular paracetamol, NSAIDs if not contraindicated, oral morphine for breakthrough pain usually sufficient in addition to local anaesthetic
plus adrenaline infiltration by surgeon. Superficial cervical plexus blocks may also be used.
> > Thromboembolic prophylaxis: leg compression devices indicated due to surgery duration.
> > Warming mattress/forced air warmer and warmed fluids indicated due to surgery duration.
b) What particular issues must the anaesthetist consider during the induction, maintenance and extubation phases of anaesthesia for a euthyroid patient having a total thyroidectomy? (11 marks)
Extubation
Extubation:
» Assessment by surgeon for tracheomalacia (fibreoptic scope through tube, tube can be retracted to allow visualisation) or recurrent laryngeal nerve palsy (visualisation of vocal cords with laryngoscopy) if concerns.
Extubation can be deferred if such complications have occurred.
> > Risk of failure of haemostasis: aim for smooth extubation, can continue remifentanil infusion if used, ensure analgesia sufficient, sitting up.
> > Risk of laryngeal oedema increases the risk of problems at extubation: dexamethasone given intraoperatively, then manage extubation
in standard manner, ensuring patient sitting up, fully awake, fully reversed (assess train-of-four, appropriate dosing of neostigmine with glycopyrrolate, consideration of sugammadex use if high risk).
c) Describe the specific
postoperative problems that may
be associated with this operation.
(4 marks)
> > Failure of haemostasis: causing airway compression, necessitating removal of clips on ward or urgent return to theatre.
> > Tracheomalacia: not detected prior to end of surgery, causing airway obstruction necessitating immediate reintubation. Rare.
> > Recurrent laryngeal nerve palsy: can be difficult to detect on direct visualisation prior to extubation. Uni/bilateral may cause stridor, difficulty
breathing. Unilateral may cause hoarse voice, difficulty phonating.
> > Laryngeal oedema: increased likelihood after complex surgery or difficult airway management.
> > Hypocalcaemia: due to trauma to or removal of parathyroid glands.
> > Pneumothorax: if retrosternal dissection has been necessary due to goitre size.