Rodriguez Notes

Question 1

What conditions are indicative of Liver Disease?

Answer 1

Jaundice
Portal Hypertension
Disordered Homeostasis
Release of Enzymes into body fluid
Jake Pawns DRums

Question 2

What is the most specific clinical manifestation of Hepatic Dysfunction?

Answer 2

Jaundice
Not present in many individuals with Liver Disease

Question 3

How do we store a Jaundice Specimen?

Answer 3

Seperated from cells
2 days at room temp
1 week at 4C
Forever at -20C

Question 4

When does Portal Hypertension occur?

Answer 4

Obstruction to portal flow anywhere along its course

Question 5

What causes the majority of Portal Hypertension?

Answer 5

Cirrhosis

Question 6

What is one the leading causes of morbidity and mortality in patients with Cirrhosis?

Answer 6

Bleeding from Varices

Question 7

What are the factors that govern the ability of Liver Enzymes to assist in diagnosis?

Answer 7

Tissue Specificity
Subcellular Distribution
Enzyme Activity
Patterns of release
Clearance from plasma
This Shrine Eats People like Candy

Question 8

What are the two major components of Chronic Hepatitis?

Answer 8

Fibrosis and Necroinflammatory Activity

Question 9

Which Hepatitis requires a vaccination?

Answer 9

Hepatitis B
Body fluids (Parenteral/Vertical)
DNA virus

Question 10

What is important about HBsAg (Hepatitis B surface Antigen)?

Answer 10

Detects current HBV infection
First serological marker to appear and last to dissapear

Question 11

What is an RNA Flavivirus with a high rate of mutation?

Answer 11

Hepatitis C
Injection drug use

Question 12

What percentage is HCV infection responsible for Acute Hepatitis?

Answer 12

10%-15%

Question 13

What is used to detect active infection of Hepatitis C?

Answer 13

HCV RNA

Question 14

Patients WITH inflammation associated to liver fat accumulation are diagnosed with what?

Answer 14

Nonalcoholic Steatohepatitis (NASH)

Question 15

Patients WITHOUT inflammation associated to liver fat accumulation are diagnosed with what?

Answer 15

Nonalcoholic Fatty Liver Disease (NAFLD)

Question 16

What are inherited Liver diseases that present as Chronic Hepatitis?

Answer 16

Hemochromatosis
A1-Antitrypsin deficiency
Wilson Disease

Question 17

What is responsible for Intrahepatic Cholestasis?

Answer 17

Functional or Mechanical Problems

Question 18

What is responsible for Extrahepatic Cholestasis?

Answer 18

Physical Obstruction of the bile ducts

Question 19

What is an autoimmune disorder targeting Intrahepatic Ducts found in middle aged women?

Answer 19

Primary Biliary Cirrhosis (PBC)

Question 20

What is an inflammatory disease affecting Extrahepatic ducts found in men?

Answer 20

Primary Sclerosing Cholangitis (PSC)

Question 21

What are the most common symptoms of Primary Sclerosing Cholangitis?

Answer 21

Pruritus (Itching)
Intermittent Abdominal Pain
Fever

Question 22

What is the most important Primary liver tumor?

Answer 22

Hepatocellular Carcinoma (HCC)