Rsnal Tubular Acidosis

Question 1

Salient features of RTA?

Answer 1

• GFR may be normal or slightly reduced
• Normal anion gap
• Hyperchloremia
• metabolic acidosis
• urinary bicarbonate

Question 2

Mechanisms behind renal tubular acidosis?

Answer 2

• Failure of the renal tubules to retain bicarbonate
• Failure of the renal tubules to secrete hydrogen ions

Question 3

Classification of RTA ?

Answer 3

• Type 1, Type 2, Type 4, Type 3
• dRTA - pRTA - Alsosterone resistance- mixed

Question 4

Salients features of TyPe 1 RTA? (Distal RTA)

Answer 4

• occurs commonly in children
• failure of distal tubules to secrete hydrogen ions
• urinary ph is >5.5
• metabolic acidosiswuth hyperchloremia
• hypocitraturia
• hypokalemia
• bicarbonaturia
• low ammonium ion in the urine
• Urolithiasis (stones in the tubules)
• Nephrocalcinosis (generalized calcium deposits in the kidneys)
• Muscle weakness

Question 5

Subtypes of Distal RTAvm?

Answer 5

• Classic dRTA
• Back leak dRTA
• Voltage dependent dRTA
• Incomplete dRTA