RT 3000 Final Exam Flashcards
(195 cards)
T or F: A clinical trial protocol is a formal document that clearly describes the details of a proposed research study.
True.
A clinical trial protocol is a formal document that outlines the details of a proposed research study, including its objectives, design, methodology, participant eligibility criteria, and data collection procedures, ensuring the safety of participants and the integrity of the data collected.
T or F: A Phase 1 clinical trial usually involves more than 100 subjects (participants).
False.
During Phase 1 studies, researchers test a new drug in normal volunteers (healthy people). In most cases, 20 to 80 healthy volunteers or people with the disease/condition participate in Phase 1.
A Phase 2 clinical trial usually involves more than 100 subjects (participants)- NOT PHASE 1.
Phase II studies determine the effectiveness of an experimental drug on a particular disease or condition in approximately 100 to 300 volunteers. This phase may last from several months to two years. A Phase II trial answers the question, “Does Drug X improve Disease Y?”
T or F: A retrospective study involves the review of patient medical records.
True.
A retrospective study analyzes existing data, which in the medical field often means reviewing patient medical records, also called “chart reviews”.
T or F: Phase 2b trials are sometimes called pilot trials.
False.
Phase IIa studies are usually pilot studies designed to find an optimal dose and assess safety (‘dose finding’ studies). Phase IIb studies determine how well the drug works in subjects at a given dose to assess efficacy (‘proof of concept’ studies).
“Phase II trials can be subdivided into Phase IIa and Phase IIb; the former is essentially a pilot study involving a limited number (∼50) of participants, whereas the latter will often recruit several hundred epilepsy patients. This subdivision allows for protocol amendment and optimization.”
T or F: Long-term safety and effectiveness of a new treatment would be evaluated in Phase 3 clinical trials.
True.
Phase 3 trials are used to collect more information about how safe a drug is and how well it works. Phase 3 trials will often compare an experimental treatment with the current standard of care to see if it works as well or better, or has fewer side effects, than what is already available to patients.
T or F: TSI treatment is delivered in preparation for a bone marrow transplant.
False.
TBI (Total Body Irradiation) is delivered in preparation for a bone marrow transplant.
While both TSI (Total Skin Irradiation) and TBI (Total Body Irradiation) are forms of radiation therapy, the key difference is that TSI only targets the skin surface, while TBI delivers radiation to the entire body, including internal organs, making TSI significantly less invasive and primarily used for skin cancers like mycosis fungoides, while TBI is typically used as preparation for a bone marrow transplant to suppress the immune system before receiving donor cells.
T or F: A benefit of using Strontium-89 is that high radiation doses can be given to bone metastases with minimal doses to soft tissue.
True.
“Radiopharmaceutical agents can also be used for the palliation of metastatic bone disease. Strontium-89 ans Samarium-153 have been shown to provide pain relief for patients with matastatic prostate carcinoma and, in some cases, with breast cancer that is metastatic to the bone.” - Pg 575 in Washington (4th edition)
T or F: To eliminate bias in clinical trials, study subjects may be allowed to choose the treatment assignment in which they wish to participate.
False.
To eliminate bias, clinical trials use randomization to randomly assign patients to treatment groups.
Randomization helps to ensure that the treatment a patient receives is not systematically connected to their prognosis. This helps to prevent selection bias, which can occur when the treatment a patient receives is influenced by factors other than the treatment itself.
T or F: Health care providers caring for LDR implant patients must limit direct care time to 30 minutes per shift.
True
“Limit contact with the client for 5 minutes each time, a total of 30 minutes per 8-hour shift”
T or F: Patients who have multiple, painful, metastatic lesions may benefit from single dose Hemibody irradiation.
True.
https://www.onclive.com/view/a-comprehensive-review-of-hemibody-irradiation-for-patients-with-bone-metastases
T or F: TSI treatment may be administered using electrons or x-rays.
False.
TSI (Total Skin Irradiation) is administered using electrons because the goal of treatment is to only treat the surface level of the body (the skin) and not the internal organs.
Total skin electron beam therapy (TSEBT) is a radiation treatment for the whole surface of your skin. It is used to treat cutaneous T-cell lymphoma (CTCL) and/or mycosis fungoides (MF), a type of lymphoma that affects the skin.
In TSEBT, a type of radiation is used, called electrons. This beam goes into the first 1-2 centimeters of your body. This treats the skin while limiting radiation to other tissues and organs.
T or F: Most cancer pain can be eliminated by non-opioid medications, such as NSAIDs.
False.
While non-opioid medications like NSAIDs can manage mild to moderate cancer pain, for more severe cancer pain, opioids are often necessary to effectively eliminate pain.
T or F: A stellate ganglion block is an injection of local anesthetic to block the sympathetic nerves located on either side of the voice box in the neck.
True.
A stellate ganglion block is an injection of local anesthetic specifically targeting the sympathetic nerves situated on either side of the voice box in the neck.
T or F: Many patients believe that pain is an expected and inevitable consequence of their cancer.
True.
Patients may fail to report cancer pain if they expect that pain is an inevitable consequence of cancer, if they believe that pain is a useful indicator of disease activity, or if they fear that symptom discussions will shift the professional’s focus away from the treatment of disease.
T or F: A patient’s pain has both a physical and emotional component.
True.
T or F: Allodynia is an over-sensitivity to stimulus, such as touch.
True.
Allodynia is defined as “pain due to a stimulus that does not normally provoke pain.” An example would be a light feather touch (that should only produce sensation), causing pain.
T or F: Brain swelling is treated with the steroid medication Decadron.
True.
Steroids are hormones produced by the adrenal glands that are used to reduce brain swelling. The steroids used to treat brain tumors are not the same as those used by athletes. The most common steroid is dexamethasone (Decadron®). Prednisone may also be used.
T or F: Handwashing is the most important mechanism of preventing and controlling nosocomial infections.
True.
According to the CDC and other health organizations, handwashing (or more broadly, “hand hygiene”) is considered the single most important practice for preventing the spread of infections, including nosocomial infections, in healthcare settings.
T or F: The parenteral route of drug administration bypasses the gastrointestinal system.
True.
The parenteral route refers to administering liquids, such as nutrition or medications, by bypassing the gastrointestinal system.
T or F: Suppositories can only be used to administer medications rectally.
False.
Suppositories are a medication dosage form. They’re placed or inserted into the rectum, vagina, or urethra.
T or F: Non-sterile gloves and linens that fall on the floor can be picked up and used as long as they are not used on patients with open sores or infections.
False.
T or F: Patients who take Metformin should discontinue taking the medication 48 hours prior to administration of barium contrast.
False.
Patients taking Metformin should typically discontinue the medication at the time of or before receiving intravenous contrast, not barium contrast, and should not take it for at least 48 hours afterwards due to the potential risk of kidney damage from the contrast agent, which could lead to lactic acidosis associated with Metformin use.
Barium contrast is not typically associated with the need to stop Metformin
as it is administered orally and does not significantly affect kidney function like intravenous contrast.
T or F: Nonionic contrast does not contain iodine.
False.
Nonionic contrast does contain iodine; it is a type of iodinated contrast media, meaning the contrast agent is based on iodine, but it is classified as “nonionic” due to its chemical structure which does not dissociate into charged particles when injected, leading to fewer side effects compared to ionic contrast.
T or F: An emergency situation commonly associated with an allergic reaction to contrast media is hypovolemic shock.
False.
Hypovolemic shock is a medical emergency that occurs when the body loses too much blood or fluids, making it difficult for the heart to pump enough blood to the body. If left untreated, it can lead to organ damage, multiple organ failure, and death.