S18 Cardio biochemistry Lipoproteins Flashcards Preview

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Flashcards in S18 Cardio biochemistry Lipoproteins Deck (13):
1

components of lipid profile

total cholesterol
triglycerides
HDL-cholesterol
LDL-cholesterol
Non-HDL Cholesterol
Cholesterol/HDL Ratio

2

LDL cholesterol calculation

Total cholesterol- HDL cholesterol- Griglycerides/5

3

IDL

intermediate density lipoproteins.

return endogenous lipids to liver

4

ApoA's are found in

chylomicrons and HDL

5

Chylomicrons have

ApoB48

6

LDL has

ApoB100

7

ApoC are associated

with all classes

8

ApoE is associated with

older remnant lipoproteins and all classes

9

High cholesterol

LDL over 150 mg/dl

Total Cholesterol above 240 mg/dl

10

Niemann-pick type C disease

Cholesterol not released fro lysosome

cholesterol accumulates

cells die (nerve cells), early death

11

HDL is taken up by the

SR-B1 receptor (on many cells) or the HDL receptor (mainly liver)

12

HDL requires two enzymes

LCAT (lecithin cholesterol acyl-transferase) helper enzyme esterifies cholesterol, and secures cholesterol for transport.

CETP exchanges cholesterol esters for triglycerices between HDL and VLDL.

13

Lp(a)

may interfere with break down of clots, inhibiting the fibrolytic activity of plasminogen