S18 Cardio biochemistry Lipoproteins Flashcards Preview

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Flashcards in S18 Cardio biochemistry Lipoproteins Deck (13)
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1
Q

components of lipid profile

A
total cholesterol
triglycerides
HDL-cholesterol
LDL-cholesterol
Non-HDL Cholesterol
Cholesterol/HDL Ratio
2
Q

LDL cholesterol calculation

A

Total cholesterol- HDL cholesterol- Griglycerides/5

3
Q

IDL

A

intermediate density lipoproteins.

return endogenous lipids to liver

4
Q

ApoA’s are found in

A

chylomicrons and HDL

5
Q

Chylomicrons have

A

ApoB48

6
Q

LDL has

A

ApoB100

7
Q

ApoC are associated

A

with all classes

8
Q

ApoE is associated with

A

older remnant lipoproteins and all classes

9
Q

High cholesterol

A

LDL over 150 mg/dl

Total Cholesterol above 240 mg/dl

10
Q

Niemann-pick type C disease

A

Cholesterol not released fro lysosome

cholesterol accumulates

cells die (nerve cells), early death

11
Q

HDL is taken up by the

A

SR-B1 receptor (on many cells) or the HDL receptor (mainly liver)

12
Q

HDL requires two enzymes

A

LCAT (lecithin cholesterol acyl-transferase) helper enzyme esterifies cholesterol, and secures cholesterol for transport.

CETP exchanges cholesterol esters for triglycerices between HDL and VLDL.

13
Q

Lp(a)

A

may interfere with break down of clots, inhibiting the fibrolytic activity of plasminogen