S1B6 - Neoplasia II

Question 1

Xeroderma pigmentosum

A) Mismatch repair

B) Nucleotide excision repair

C) Recombination repair

Answer 1

Question 2

What type of metabolism do tumor cells switch to to enable rapid cell growth?

Answer 2

Question 3

What are the most common types of genetic mutations in carcinogenesis?

Answer 3

Question 4

Process of tumor induction in previously initiated cells.

A) Initiation

B) Promotion

Answer 4

Question 5

Bloom syndrome, Faconi anemia, hereditary breast cancer syndromes.

A) Mismatch repair

B) Nucleotide excision repair

C) Recombination repair

Answer 5

Question 6

What is the paradigm shift of the classification of cancer?

Answer 6

Question 7

What are proto-ongogenes?

Answer 7

Question 8

Hereditary nonpolyposis colon cancer syndrome (Lynch syndrome)

A) Mismatch repair

B) Nucleotide excision repair

C) Recombination repair

Answer 8

Question 9

What is the #1 target of chemical carcinogens?

Answer 9

Question 10

True or false: ionizing radiation is more likely to cause cancers of lung and breast?

Answer 10

false

Question 11

What are the possible mechanisms of cancer evasion of the host response?

Answer 11

Question 12

What are the two important DNA targets of carcinogens listed in the lecture?

Answer 12

Question 13

Which DNA viruses are carcinogenic?

Answer 13

Question 14

Describe the three steps of the ability of cancer to invede and metastasize.

Answer 14

Question 15

What is the consequence of inactivation of tumor suppression genes?

Answer 15

Question 16

What are oncoproteins?

Answer 16

Question 17

What is the consequence of oncogene activation?

Answer 17

Question 18

What ability makes tumor cells immortal?

Answer 18

Question 19

How can defective DNA repair proteins lead to cancer?

Answer 19

Question 20

What can explain the natural history of cancer and the changes in tumor behavior following therapy?

Answer 20

Question 21

What activity do oncogenes promote?

Answer 21

Question 22

What bacteria is carcinogenic?

Answer 22

Question 23

What are the two steps involved in chemical carcinogenesis?

Answer 23

Question 24

What kind of genetic damage is at the heart of carcinogenesis?

Answer 24

Question 25

Do DNA repair pathways directly affect cell proliferation?

Answer 25

Question 26

What are the 4 classes of normal regulatory genes that are the principal targets of genetic damage?

Answer 26

Question 27

What specific types of cancers have an increased risk with ionizing radiation?

Answer 27

Question 28

Which is normal and which is HPV infected?

Answer 28

Question 29

What are the hallmarks of cancer?

Answer 29

Question 30

What are genomic instability syndromes?

Answer 30

Question 31

What is the prototypic anti-apoptotic protein?

Answer 31

Question 32

Induction of irreversible mutations in the genome.

A) Initiation

B) Promotion

Answer 32

Question 33

Overexpression of what protein extends cell survival?

Answer 33

Question 34

Which RNA viruses are carcinogenic?

Answer 34

Question 35

Describe the development of cancer by a stepwise accumulation of mutation.

Answer 35

Question 36

Are DNA repair genes directly oncogenic?

Answer 36

Question 37

What are the 4 types of carcinogens?

Answer 37