Saliva Flashcards
(27 cards)
What effects does head and neck radiotherapy have on salivation?
Effects are rapid (days) and long lasting
Initial effect: Reduces gland function
Later effects: Kills cells, esp acinar cells
What disease effect salivary glands?
mumps
Mumps frequently affects the _____ gland and results in _____
parotid glands and results in painful swelling of salivary glands due to the obstruction of ducts.
Sialoliths
stones, found in submandibular glands, obstruct secretion and cause painful swelling
What viruses replicate and are shed into saliva?
epstein barr and herpes.
What kind of glands are salivary glands
exocrine glands
What are the 3 major salivary glands?
- parotid (IX)
- submandibular (VII)
- Sublingual (VII)
What are the 2 minor salivary glands?
- Von Ebner’s glands (IX)
2. Labial, Palatal, Buccal, Lingual
What kind of gland is the parotid gland?
serous gland. SEcretes a watery saliva and is the main source of the enzyme amylase which initiates the breakdown of starch.
What kind of glands are von ebners glands?
serous
Enzyme: Lingual lipase (breaks down Fatty acids and tryglycerides.)
Major functions of the saliva
- protection –> Mucins
- buffering –> Bicarbonate
- tooth integrity –> Proline rich proteins and statherin
- antimicrobial –> Lysozyme, peroxdiase, defensins, histatins, IgA
- tissue repair –> growth factors
- Digestion –> mucins, amylase, lipase
- Taste –> water
which duct does the parotid gland release saliva?
stensons duct
Submandibular gland uses what duct?
whartons duct
Sublingual gland. Uses what ducts?
Bartholins and rivinus’s ducts
What are salivaory glands made up of (2) what do they do?
- Stroma (CT) –> supporting role –>provides structural support forming the capsule organizing gland into lobes.
- Parenchyma (Epi) –> do work of gland –> makes saliva and discharges it into the final destination
What structure does the stroma have that encompasses the salivary glands seperates it from surround tissue?
capsule
What divides the salivary gland into lobes?
Septa
What does the stroma contain?
- Fibroblasts–> makes collagen that is the major component of ECM
- BV ( supplies parenchyma)
- Nerve fibers (supply parenchyma.. mainly the acinar cells and myoepithilial cells)
- Plasma cells (secrete antibodies-IgG-one type of molecule found in saliva… plasma in the stroma make these antibodies )
- Fat cells (increase with age)
What is the parenchyma comprised of (2) ?
- Acini “grapes” secretory portion. Makes saliva.
2. Ducts (intercalated ducts that carry acini crap and then send the crap to striated ducts and then excretory ducts.)
What kinds of acini cells are there?
serous (partoid)
mucous (minor glands)
Mixed (submandibular and sublingual glands)
When do salivary glands develope? what gland is first?
what is the glands origin?
6th week
parotid is first
then submandibular
then sublingual and minor
Origin: paranchyma
Acini and ducts develope from _____
ecto and endo
CT stroma develope from?
neural crest
1 Cleft formation:
One mechanism that controls clefting is the suppression of _____ in a certain region of the cell.
E-Cadherin expression
