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Oral Bio 2 > Saliva Gland > Flashcards

Saliva Gland Flashcards

1
Q

Salivary Glands

A

Sublingual gland, parotid gland, submandibular gland

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2
Q

rat salivary gland

A

down and behind ear- lacrimal gland is the in front one

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3
Q

mucous cells

A

minor salivary glands and sublinguals

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4
Q

serous

A

parotid gland

water and proteins, physiologic fluid

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5
Q

mucos

A

minor slaivary glands and sublingual

slippery, protection

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6
Q

gland diagram

A

look in notes

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7
Q

saliva glands are

A

neurochemical
dual innervated
both go to more saliva produced

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8
Q

sympathetic nervous system

A 
T1-T3
norepi to Beta adrenergic
increased cAMP
more saliva
develops postnatal (p3-p5)
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9
Q

parasympathetic nervous system

A

cranial nerves 9 and 7
IP3 and DAG
ACH to M3R
development At the same time of gland

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10
Q

bicarbonate secretion

A

CO2 diffuses into cell and is combined with water to make carbonic acid, it dissociates the H+, in an activated cell bicarb leaves through secretory vesicles

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11
Q

chloride mediated secretion

A

activation of a g protein (ach on m3) - more IP3- increased calcium- ion channel activation- Chlroide flows out of cell, sodium follows to keep neutral- water follows that

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12
Q

h2o channels

A

aquaporin 5

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13
Q

chloride channels

A

tmem16a

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14
Q

straited ducts

A

pump on ions to make saliva hypotonic
na and cl out
k in
“stage 2” of saliva secretion

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15
Q

protein secretion

A

beta adrenergic receptor- nor epi on g protein- cAMP- leads to vesicles dumping out protein & glycosylation and phosphorylation in ER & protein kinase in nucleus

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16
Q

constitutive pathway

A

transport cell membrane protein in vesicles to cell membrane and does not require a NT

17
Q

consitutive like pathway

A

transport of secretory proteins in vesicles that bud from golgi- minimal agonist concentration

18
Q

major regulated pathways

A

rapid release of granules that fusion to the luminal cell surface
high doses of NT

19
Q

minor regulatory pathways

A

slow release of vesicles that relase from maturing secretory granules
low dose NT

20
Q

saliva functions

A

lubricate, ion reservior, buffer, clean, antimicrobial. pellice, agglutination, digestion, taste, exretion, water balance

21
Q

ectodermal dysplasia

A

can lead to non functioning saliva glands

22
Q

Sjorgrens syndrome

A

autoimmune to exocrine glands (salivary lacrmial)

23
Q

radiation can

A

kill salivary glands

24
Q

salivary gland development

A 
parotid = ectoderm
sublingaul/submandibular=  unknown (mix of mesodermal and ectodermal?)
minor= mesodermal
25
Q

p63

A

marker for ectodermal organs

26
Q

prebud

A

11.5 days in mice
2-5 weeks in humans
placode at specific sites in the oral cavity

27
Q

initial bud

A

12.5 days mice
6-8 weeks human
expansion and invagination of the placode as an epithelial bud into a condensing mesenchyme

28
Q

pseudoglandular

A

13.5 days in mice
10 weeks in human
epithelium undergoes successive rounds of branching morphogenesis, which involves cleft formation, end bud expansion, and duct elongation, finally appearing as solid end buds and cords of epithelial cells

29
Q

canalicular

A

14.5 E in mice
12 weeks in humans
Branching morphogenesis continues until approximately 12 weeks where cells form a lumen and polarize appearing the lumen of the ducts and the end buds,

30
Q

terminal bud

A

17.5 E in mice
16 weeks in humans
By week 16 striated and IC duct are distinguishable. From 20-24 weeks acinar cells begin to predominate

31
Q

salivary glands develop because of

A

epthelial mesenchyme interactions

32
Q

consitutive pathway

A

Proteins are continuously secreted from the cell regardless of environmental factors. No external signals are needed to initiate this process. Proteins are packaged in vesicles in the Golgi apparatus and are secreted via exocytosis, all around the cell. Cells that secrete constitutively have Golgi apparatus scattered throughout the cytoplasm. Fibroblasts, osteoblasts and chondrocytes are some of the many cells that perform constitutive secretion.

33
Q

regulative pathwaay

A

only secreted in response to a specific signal, such as neural or hormonal stimulation

34
Q

more timeline

A

Branching: 12 wks
Desmosomes, serous granules and microvilli: 13-15 wks
Striated and IC duct: 16
Acinar cells: 20-24 wks

35
Q

parotid gland duct

A

stensens

36
Q

submandibular duct

A

whartons

37
Q

sublingual duct

A

rivinus then bartholins

Oral Bio 2 (17 decks)

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