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salivary glands Flashcards

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1
Q

what are the 3 main salivary glands

A

parotid, submandibular, sublingual

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2
Q

what nerve supplies the major salivary glands

A

facial nerve

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3
Q

during the parasympathetic response, does salivary flow increase or decrease
during the sympathetic response (fight) does salivary flow increase or decrease

A

increases
decreases

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4
Q

name the different ways you can test for salivary gland diseases

A

MRI
sialometry - measures saliva flow
plain film radiography
ultrasound
biopsy
endoscopy

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5
Q

how do salivary gland disease present

A

lumps
dry mouth
hypersalivation

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6
Q

what are sialogoues and give examples

A

substances which increase saliva flow such as lemon drops and pineapple

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7
Q

what causes dry mouth

A

sjogens
anxiety
medications
HIV
salivary gland disease

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8
Q

what are some causes of siallhorea (hypersalivation)

A

cerebral palsy
parkinsons

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9
Q

Name the different types of salivary gland disorders

A

Obstructive SG dx
Xerostomia
Sialorrhoea
Sarcoidosis/HIV/GvHD related salivary gland disease
Cancers
Benign neoplasias e.g. pleomorphic adenoma and Warthin’s tumour
Benign cysts/pseudocysts
Acute/chronic sialadenitis
Frey’s syndrome
Developmental abnormalities e.g. atresia or hypoplasia
Primary and Secondary Sjögren’s syndrome
Sialosis

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10
Q

what are the different types of Sjogren’s disease and how do you differentiate the 2

A

primary and secondary
primary isnt associated with a connective tissue
secondary is associated with connective tissue e.g. rheumatoid arthiriris

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11
Q

what is sjogrens

A

an autoimmune disease which self damages the exocrine system (salivary glands) therefore causing dry eyes and dry mouth

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12
Q

how to test for sjogrens

A

blood test called ANA which specifically look for RO and LA antibodies

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13
Q

how many minor saliva glands are there, where in the mouth are they and what % saliva do they present

A

450 minor salivary glands,
distributed through mucosa, lips, cheeks, tongue, roof of mouth and retromolar pad

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14
Q

what is the normal saliva flow rate for a non-stimulated and stimulated mouth

A

0.3-0.4ml/ minute
4-5 ml/ minute

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15
Q

What is the composition of saliva

A

inorganic molecules - sodium, potassiom, fluoride, chloride, iodine, calcium phosphate
organic molecules- urea, uric acid, amino acids , glucose, lactate, fatty acids
macromolecules- glycoprotein, amylase, IgA, IgM etc, lipids, hormones, carbs

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16
Q

what is the difference between endocrine and exocrine glands

A

endo secrete hormones into blood stream such as pituitary, ovaries, testes
exo secretes substaces into ducts which secrete to target tissue e.g. saliva, sweat and mucous

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17
Q

when would you do a venous blood sample and what does it consist of

A

mostly for dry mouth (sjogens)
- FBC
- hb1ac
- serum ace levels
- U & E and LFT (urea and electrolytes)
-ANA screen ( looks for antibodies that attack your own cells)
- serum immunoglobulins (IGA,IGM etc)

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18
Q

what is ultrasonography

A

high frequency sound waves
quick cheap, non invasive
identifies solid lesions e.g. tumours and calculi
identifies cysts
not good for assessing SG fuction
textural changes in sjogens

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19
Q

plain radiographs

A

to identify radiopaque calculi
80% SMG calculi is radiopaque 60% parotid calculi is radiopaque
you need 2 radiographs at 90 degrees to help localise the calculus

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20
Q

what is retrograde sialography

A

radiographic eexamination of the ductal system using the medium radioiodide
this can highlight
strictures - restrictions in the ducts
sialectasia- dilations in the ducts
not good to identify tumours
Punctate sialectasis – typical of Sjögren’s Syndrome (“tree in winter” appearance)

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21
Q

what is MRI

A

does not involve ionising radiation
demonstrates the extent and relationships of tumours to normal anatomy

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22
Q

collection of parotid saliva

Study These Flashcards
A

lashley cup held in place over one parotid papilla by suction
measure non stimulated and stimulated saliva volumes

23
Q

symptoms of salivary gland disorders

Study These Flashcards
A

Pain
o E.g. stretching of parotid capsule due to swelling
o Invasion of nerves by malignant neoplasms (rare compared to other causes of
pain)
Discharge from duct – may C/O foul taste
Decreased saliva – xerostomia (extremely common)
Increased saliva – sialorrhoea (very rare)

24
Q

salivary gland diseases we need to know about are:

Study These Flashcards
A
  1. Obstructive SG dx
  2. Xerostomia
  3. Sialorrhoea
  4. Sarcoidosis/HIV/GvHD related salivary gland disease
  5. Cancers
  6. Benign neoplasias e.g. pleomorphic adenoma and Warthin’s tumour
  7. Benign cysts/pseudocysts
  8. Acute/chronic sialadenitis
  9. Frey ’s syndrome
  10. Developmental abnormalities e.g. atresia or hypoplasia
  11. Primary and Secondary Sjogren’s syndrome
25
what is sialadenitis and what are the 2 types
inflammation of the salivary gland there is obstructive sialadenitis or infective
26
what causes obstructive salivary gland disease
calculi, strictures (narrowing sg), or infections, or local swellings from cancers or other structures like like lymph nodes or mumps
27
what is another name for salivary gland calculi
sialoliths
28
what is the most common cause for obstructive salivary gland disease
salivary gland calculi- a hard sludge may be asymptomatic can occur in major and minor salivary glands
29
what are strictures
trauma to the salivary duct followed by fibrosis- thickening of the tissue causing narrowing of SG usually occur in conjunction with calculi
30
how do you treat strictures
balloon dilation but future re stenosis may occur
31
how do you treat strictures
balloon dilation however they may re-stenose over time
32
what is acute salivary gland obstruction and how is it caused
usually caused by calculus or a mucous plug, occurs before a meal resolves around 30 mins
33
how do you manage salivary calculi
if asymptomatic leave alone if small symptomatic - incise duct and remove stone large stones- remove the whole gland or remove stone using endoscopy and then lithotripsy- ultrasonic shock waves to stone
34
what are the risks associated with removing the submandibular gland
damage to mandibular nerve - diminishes motor innervation of muscles damage to lingual nerve- diminished sensory sensation to lingual tissues damage to hypoglossal nerve- diminished motor function to tongue
35
what are the risks associated with (complications) removal of parotid gland
damage to facial nerve may lead to unilateral facial weakness of all branches freys syndrome
36
what causes xerostomia
medications diabetes mellitus anxiety dehydration mouth breathing acute infection recreational drugs radiation to salivary glands endogenous salivary gland disease such as sjogrens
37
how do drugs effect saliva production
drugs act in 3 different mechanisms : central effects in the brain anti- muscarinic effects - sympathomimetic- stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system (activates receptors)
38
what type of drugs cause xerostomia give examples
tricyclic depressants e.g. amitriptyline antihistamines, diuretics, antipsychotic, antiparkinsonian
39
which recreational drugs can cause xerostomia
amphetamines, ecstatsy
40
what advice would you give to pts to manage dry mouth
- smoking cessation minimise alcohol - increase water intake in small sips - avoid caffeine drinks - sugar free chewing gum - avoid cariogenic good - caries increasing foods such as cakes, biscuits - use high fluoride toothpaste - increase dental check ups - discourage mouth breathing - identify and treat oral candidosis - OHI perio
41
what is sialorrhoea and what causes it
- too much saliva this can be due to: parkinsons, cerebral palsy - rabies - pregnancy - acute viral infection - teething - new dentures - pancreatitis - some drugs such as clozapine
42
how do you manage sialorrhea
anti muscarinics- glycopyronium bromide botulinum toxin A (botox) can be injected into salivary glands to reduce acetylcholine and :. inhibit salivation surgical management- incision of gland
43
what is HIV salivary gland disease
this type of salivary gland disease is common in children with HIV HIV can cause cystic changes in salivary glands involves the swelling of one or both parotid glands Xerostomia common in hIV
44
what causes salivary gland cancers
benign and malignant neoplasms in malignanies of the salivary gland, you may find cervical lymphodenapthy representing local metastasis
45
what are the 2 types of benign neoplasia
pleomorphic adenoma warthins tumour
46
where are pleomorphic adenoma most commonly found what % of benign neoplasia do they make up
parotid gland 80%
47
what is the main difference between pleomorphic adenoma and warthins syndorme
pleomorphic is very common 80% but poorly encapsulated :. incision is harder warthins less common but better encapsulated :. easier incision
48
what is the technical name for benign cycts
mucocles
49
what are mucocles
a cyst of a minor salivary gland usually on floor of mouth
50
how can you identify mucocles
they present as persistent fluctuant swellings which transilluminate in the lower lip or buccal mucosa at a 'biting distance'
51
what is a ranula
a sialocyst arising from the floor of mouth from a sublingual gland some are unilateral and may raise the tongue can sometimes extend to pharynx
52
how would you treat a ranula
marsipulation- drainage of the cysts excision- cutting the cyst out- this is rarely done
53
which gland does acute sialadenitis usually affect
parotid
54
which gland does chronic sialadenitis mostly affect
submandibular

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