Salivary Glands

Question 1

salivary glands have what type of secretory portions?

Answer 1

compound tubuloacinar

Question 2

minor salivary glands arise from?

Answer 2

ectoderm and endoerm- week 12

Question 3

sublingual glands arises from

Answer 3

endoderm- wk 8

Question 4

parotid gland arises from

Answer 4

ectoderm - wk 6

Question 5

submandibular glands arise from

Answer 5

endoderm-week 6-7

Question 6

parotid anlagen develops where?

Answer 6

near corners of stomodeum- develops from a groove like invagination of ectoderm in the crease between the maxillary and mandibular swellings

Question 7

sublingual anlagen develops where?

Answer 7

develops from buds in the sulcus surrounding the sublingual folds on the floor of the mouth. Lateral to the submandibular primordia

Question 8

submandibular anlagen develops where?

Answer 8

bilaterally from bud in the sulcus surrounding sublingal folds in the floor of the mouth.
-cords grow posterior and lateral to the tongue

Question 9

myoepithelial cells arise from

Answer 9

neural crest cells

Question 10

2 ways the parotid unique

Answer 10

1. intragladular lymph nodes

2. epithelial buds grow, branch and extend around the facial nerve but parotid is not innervated by the facial nerve

Question 11

in canalization, where to the lumens first appear?

Answer 11

proximal by the oral epithelium and the distal

Question 12

when does the first cleft form?

Answer 12

stage 3-initiation of branching in the terminal parts of epithelial cord

Question 13

what surrounds each acini?

Answer 13

myoepithelial cells?

Question 14

in cytodifferentiation what 3 things can the terminal bulbs become?

Answer 14

acini, myoepithelial cells, duct cells

Question 15

branching requires what for this to occur?

Answer 15

collagen type 3

Question 16

what type of collagen provides support and maintains the structure?

Answer 16

type 1 and 4

Question 17

what secretes collagen type 3?

Answer 17

fibroblasts

Question 18

what inhibits n-linked glycosylation ?

Answer 18

tunicamycin

Question 19

what does tunicamycin interfere with?

Answer 19

interferes with calcium which inhibits cleft formation and localized cell proliferation= no branching.

Question 20

need ______ to make to ECM. the ECM contains ______ which initiates branching in the terminal parts of the epithelial cord

Answer 20

fibroblasts

collagen type 3

Question 21

what growth factor regulates branching

Answer 21

EFG

Question 22

how is FGF important?

Answer 22

stalk elongation

Question 23

what does treatment with hyaluridontase do to the basal lamina?

Answer 23

disrupts basal lamina, calcium interference, inhibits cleft formation and local cell proliferation

Question 24

what induces the oral epithelium to form a bud

Answer 24

mesenchyme induces proliferation in epithelium

Question 25

what is a reason you would not form a salivary gland?

Answer 25

disrupt the basal lamina

Question 26

what causes the cells of the glands to form tight junctions?

Answer 26

mechanoreceptors on epithelial cells sense the increased hydrostatic pressure from the secretion of presumptive duct cells

Question 27

what is involved in the positioning of the glands?

Answer 27

BMP signaling and HOX genes