Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Oral Pathology > Sample Questions Blood Disorders > Flashcards

Sample Questions Blood Disorders Flashcards

1
Q

Oral manifestations of iron deficiency anemia

A

angular chelitis
atrophic glossitis
mucosal pallor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Plummer-Vinson syndrome

A

rare condition in middle aged Scandinavian women
chronic Fe deficiency
dysphagia, atrophic mucositis of aerodigestive tracts
predisposition to oral/esophageal SCC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

RBCs in iron deficiency anemia

A

hypochromatic and microcytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Clinical symptoms of pernicious anemia

A

fatigue, headache, breath shortness
paresthesia, tingling, numbness of extremities
burning/painful tongue, lips, and buccal mucosa
atrophic, pale, erythematous oral mucosa
loss of tongue filiform papillae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

RBCs in pernicious anemia

A

macrocytic and hyperchromatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Clinical symptoms of sickle cell crisis

A

extreme pain from ischemia and infarction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Most affected areas during sickle cell crisis

A

long bones, lungs, abdomen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Radiographic features of sickle cell anemia

A

step ladder trabeculation of posterior mandible

hair on end appearance of calvarium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cause of thalessemia

A

decreased synthesis of alpha or beta globulin Hb chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Age predilection of thalessemia

A

children and young adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Clinical features of thalessemia

A

jaundice
fever
malaise
weakness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Maxillary enlargement in thalessemia is due to

A

bone marrow hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Radiographic features of thalessemia

A

hair on end skull films

honeycombed appearance of trabeculae in jaws

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

RBCs in thalessemia

A

hypochromatic and microcytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the risk of blood transfusions in thalessemia pateints?

A

hemochromatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Leukopenia is mainly due to a decrease in what WBC type?

A

neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Causes of agranulocytosis

A

idiopathic
congenital
drug related (chemo)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Oral manifestations of agranulocytosis

A

punched out, necrotic ulcerations of oral mucosa and tongue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Symptoms of agranulocytosis

A 
malaise 
sore throat
fever
chills
bone pain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Treatment of agranulocytosis

A

antibiotic therapy
bone marrow stimulating cytokines
cessation of drug if drug related

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Cause of cyclic neutropenia

A

idiopathic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Oral clinical features of cyclic neutropenia

A

oral ulcerations on tongue, buccal mucosa, gingiva

severe periodontal disease in children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Clinical features of cyclic neutropenia

A

fever
malaise
sore throat
URIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Leukocytosis

A

increased mature circulating WBCs

normal response to infectious diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Mono is cause by what virus? what cell types does it infect?

A

EBV infects epithelial cells and B lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Oral manifestations of mono

A

vesicles and ulcerations on soft palate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Life threatening risk of mono

A

hepatosplenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Cell type in acute leukemias

A

immature blast cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Cell type in chronic leukemias

A

well-differentiated WBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Genetic mutation implicated in leukemia

A

Philadelphia chromosome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Lab findings (CBC) in leukemia

A

decreased RBCs and platelets (thrombocytopenia)

normal to elevated WBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Oral manifestations of leukemia

A

hard/soft palate and gingival hemorrhages
hypertrophic, inflamed gingiva
candida and herpetic infections
gingival infiltrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Prognosis of acute and chronic leukemias

A

acute: better prognosis in kids than adults
chronic: more common in adults, more indolent course

34
Q

Where does Hodgkin’s arise from?

A

lymph nodes

35
Q

Hodgkin’s M?F

A

M>F

36
Q

Hodgkin’s age predilcection

A

bimodal presentation

15-35y and after 50y

37
Q

Clinical presentation of Hodgkin’s

A

non-tender swelling of cervical or mediastinal lymph nodes

weight loss, fever, pruritus, night sweats

38
Q

Histopathology of Hodgkin’s

A

Reed-Sternberg cells
binucleate, owl eye giant cells with prominent nucleoli
RS cells in an inflammatory background

39
Q

Prognosis of lymphocyte predominant Hodgkin’s

A

most favorable

40
Q

Prognosis of lymphocyte depletion Hodgkin’s

A

most aggressive

41
Q

Hodgkin’s presenting with collagen bands subdividing lymph nodes

A

nodular sclerosis

42
Q

Most common site of oral involvement in non-Hodgkin’s

A

palate

43
Q

Viruses implicated in non-Hodgkin’s

A

EBV, HTLV

linked to B cell and Burkitt lymphomas

44
Q

Non-Hodgkin’s M?F

A

M>F

45
Q

Head and neck features of non-Hodgkin’s

A

firm, non-tender cervical nodes
alveolar bone loss/ tooth mobility
red/purple soft tissue swellings
oral ulcerations

46
Q

Non-Hodgkin’s resembles what oral lesion clinically?

A

pyogenic granuloma

47
Q

Most common intraoral sites of non-Hodgkin’s

A

posterior hard palate, gingiva, buccal vestibule

48
Q

What is EBV’s role in Burkitt’s lymphoma?

A

involved but not necessarily casual

49
Q

Burkitt’s age and sex predilection

A

males between 3y and 8y

50
Q

Which is more common in jaws, endemic or non-endemic Burkitt’s?

A

endemic

51
Q

Radiographic features of Burkitt’s

A

ill-defined radiolucency
tooth displacement
root resorption

52
Q

Intraoral locations of Burkitt’s lesions

A

gingiva and palate

53
Q

Histopathology pattern of Burkitt’s

A

starry sky
malignant B cells
scattered macrophages with abundant cytoplasm

54
Q

Recurrence rate of Burkitt’s

A

high

55
Q

Which has a better prognosis, endemic or non-endemic Burkitt’s?

A

endemic

56
Q

What cell type is malignant in multiple myeloma?

A

terminally differentiated B cells

57
Q

Age predilection of multiple myeloma

A

50-60y

58
Q

Clinical features of multple myeloma

A

bone pain
renal failure
recurrent infections, hypercalcemia, amyloid deposition

59
Q

Protein found in the urine of multiple myeloma patients

A

Bence-Jones protiens

60
Q

Radiographic features of multiple myeloma

A

punched out radiolucencies throughout maxilla, mandible, and skull

61
Q

Prognosis of multiple myeloma

A

high survival rae

tx can be worse than the disease itself

62
Q

Normal platelet count

A

250,000-450,000/mm3

63
Q

Thrombocytopenia

A

dcreased platelet counts, decreased platelet survival. increased splenic platelet sequestration

64
Q

Idiopathic thrombocytopenia purpura

A

acute childhood, chronic adult disorder
acute form follows viral infection
antigen binding on platelets

65
Q

Clinical features of thrombocytopenia

A

small blood vessel leakage producing petechiae
larger leakage leads to ecchymoses, hematomas
spontaneous gingival hemorrhage

66
Q

Thromboastenia

A

decreased platelet function

67
Q

Factor abnormality in Von Willebrand disease

A

VIII

68
Q

Mechanism of action of aspirin thrombastenia

A

decreased thromboxane A2 synthesis

69
Q

Capillary fragility due to a deficiency in what vitamin?

A

C

70
Q

Clinical presentation of vitamin C deficiency

A

petechial hemorrhages, ecchumoses, purpura after trauma or pressure
abnormal bone calcification and growth failure in children

71
Q

Oral manifestations of vitamin C deficiency

A

gingival inflammation, ulceration, bleeding
secondary infection of ulcers
tooth mobility
bone loss

72
Q

Hereditary hemorrhagic telangiectasia is associated with what syndrome?

A

Rendu-Olser-Weber syndrome

73
Q

Hereditary hemorrhagic telangiectasia is a disorder affecting what?

A

blood vessel wall integrity

74
Q

Clinical presentation of Hereditary hemorrhagic telangiectasia

A

small surface collections of dilated capillaries
red/violet lesions on face, oral/nasal mucosae, hands feet
lesions blanch with pressure
may be GI lesions
rupture with significant blood loss
repeated nose bleeds

75
Q

Oral manifestations of Hereditary hemorrhagic telangiectasia

A

oral lesions on lip vermillion, tongue dorsum, buccal mucosa

76
Q

Intrinsic coagulation pathway initiated by what factor?

A

XII

77
Q

Extrinsic coagulation pathway initiated by what factor?

A

tissue thromboblastin

78
Q

What is faster, the extrinsic or intrinsic coagulation pathway?

A

extrinsic

79
Q

Factor VIII deficiency/dysfunction is characteristic of what bleeding disorder?

A

Hemophilia A

80
Q

Factor IX deficiency/dysfunction is characteristic of what bleeding disorder?

A

Hemophilia B

81
Q

Oral manifestations of hemophilia

A

oropharyngeal/CNS bleeding

oral ecchymoses and bleeding may follow trauma

Oral Pathology (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions