SAQ 2014B

Question 1

Adverse effects of dantrolene?

Answer 1

muscle weakness
pulmonary oedema from fluid load
deranged LFTs

Question 2

Metabolism of dantrolene?

Answer 2

Phase 1 hepatic metabolism, main metabolite 5-OH dantrolene

renally excreted

Question 3

Define sensitivity and specificity of a test

Answer 3

Sensitivity - ability of a test to detect the presence of outcome

Specificity - ability of a test to detect the absence of outcome

Question 4

Definition of positive predictive value

Answer 4

probability that a subject with a positive test truly has the outcome