Flashcards in Sarcoidosis Deck (11):
What is sarcoidosis?
Multisystem granulomatous disorder
More common in?
What are clinical features of acute sarcoidosis?
Erythema nodosum- painful bile-red raised lesions on shins
Bilateral hilar lymphadenopathy
What are clinical features of sarcoidosis?
CXR - bilateral hilar lymphadenopathy
Dry cough, progressive dyspnoea, reduced exercise tolerance and chest pain.
Non-pulmonary - lymphadenopathy, hepatosplenomegaly, events, conjuntivitis, glaucoma, neuropathy
What tests for sarcoidosis?
Blood: Raised ESR
Raised Ca, raised immunoglobulins
ECG - arrhythmia, BBB
Lung fusion testing - reduce lung volume, restrictive deficits
CXR - bilateral hilar lymphadenopathy, peripheral pulmonary infiltrates, bulla formation (honeycombing), pleural effusion
What do you see on CXR?
What do you see of lung function test?
1 Bilateral hilar lymphadnopathy
2 BHL + peripheral pulmonary infiltrates
3: peripheral pulmonary infiltrates alone
4: bulla formation: honeycombing, pulmonary fibrosis, pleural effusion
Lung function test:
What Ix is diagnostic?
Tissue biopsy - shows non-caeseating granulomata
What management for acute sarcoidosis?
Bed rest, NSAIDs
What are indications for corticosteroids? What is given?
Parenchymal lung disease
Prednisolone PO for 4-6 weeks
What can you give in severe sarcoidosis?
Immunosuppressants - methotrexate, hydroxychloroquine, ciclosporin