Sarcoidosis Flashcards Preview

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Flashcards in Sarcoidosis Deck (11):
1

What is sarcoidosis?

Multisystem granulomatous disorder
Idiopathic

2

More common in?

Afro-CAribbeans
Women

3

What are clinical features of acute sarcoidosis?

Fever
Erythema nodosum- painful bile-red raised lesions on shins
Polyarthralgia
Bilateral hilar lymphadenopathy

4

What are clinical features of sarcoidosis?

Pulmonary disease:
CXR - bilateral hilar lymphadenopathy
Dry cough, progressive dyspnoea, reduced exercise tolerance and chest pain.

Non-pulmonary - lymphadenopathy, hepatosplenomegaly, events, conjuntivitis, glaucoma, neuropathy

5

What tests for sarcoidosis?

Blood: Raised ESR
Lymphopenia,
Raised Ca, raised immunoglobulins

ECG - arrhythmia, BBB

Lung fusion testing - reduce lung volume, restrictive deficits

CXR - bilateral hilar lymphadenopathy, peripheral pulmonary infiltrates, bulla formation (honeycombing), pleural effusion

6

What do you see on CXR?
What do you see of lung function test?

1 Bilateral hilar lymphadnopathy
2 BHL + peripheral pulmonary infiltrates
3: peripheral pulmonary infiltrates alone
4: bulla formation: honeycombing, pulmonary fibrosis, pleural effusion

Lung function test:
Restrictive deficit

7

What Ix is diagnostic?

Tissue biopsy - shows non-caeseating granulomata

8

What management for acute sarcoidosis?

Bed rest, NSAIDs

9

What are indications for corticosteroids? What is given?

Parenchymal lung disease
Uveitis
Hypercalcaemia
Neuro/cardiac involvement

Prednisolone PO for 4-6 weeks

10

What can you give in severe sarcoidosis?

Immunosuppressants - methotrexate, hydroxychloroquine, ciclosporin

11

What are causes of bilateral hilarity lymphadenopathy?

Sarcoidosis
Infection - TB
Malignancy
Organic dust disease
Pneumoconioses
Metastatic disease
Hypersensitivity pneumonitis