Sarcomere Structure Flashcards Preview

Semester 2 Molecular Medicine > Sarcomere Structure > Flashcards

Flashcards in Sarcomere Structure Deck (30)
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1
Q

Describe the T tubules

A
  • Walls are continuous with the sarcolemma

* Fluid within is continuous with the external environment

2
Q

Describe how the T tubules and the sarcoplasmic reticulum are connected

A

With junctions: involve 2 integral membrane proteins, one in the T tubule membrane and the other in the membrane of the sarcoplasmic reticulum

3
Q

What is the Sarcolemma?

A

True cell membrane and encloses the muscle fibre

4
Q

What is the role of Titin?

A

• To provide elasticity and stablilize the myosin

5
Q

What is the Myofibril?

A

Predominately composed of actin and myosin filaments

6
Q

Describe the ultrastructural basis of the I band

A

• Actin filaments bisected by the Z line

7
Q

Where is the Endomysium?

A

Separates the muscle fibres

8
Q

Describe the ultrastructural basis of the H zone

A

Region of A band which contains only myosin filaments

9
Q

Define a sarcomere

A

The portion of a myofibril that lies beween 2 successive z disks

10
Q

Describe Tropomyosin

A
  • Regulatory protein

* Overlaps the binding sites of actin for myosin and inhibits interaction when in the relaxed state

11
Q

Describe Troponin

A
  • Regulatory, calcium binding protein
  • Forms a complex with the other proteins of the thin filament (actin and tropomyosin)
  • Binds to Ca2+ reversibly and once bound, changes conformation to pull the tropomyosin away from the myosin interaction sites
  • Ca2+ binding to troponin regulates skeletal muscle contraction because it moves the tropomyosin away and allows myosin to interact with the actin
12
Q

Describe the T tubule protein

A
  • Modified voltage-sensitive Ca2+ channel

* Dihydropyridine receptor

13
Q

What are muscle fibres arranged in?

A

Bundles of fasiculi

14
Q

What are the contractile proteins of the sarcomere?

A
  • Actin
  • Myosin
  • Tropomyosin
  • Troponin complex
15
Q

Describe the protein found in the SR membrane

A
  • Ryanodine receptor

* Forms a Ca2+ channel

16
Q

What is a muscle fasicle wrapped in?

A

Perimysium

17
Q

Describe the ultrastructural basis of the A band

A

• Primarily myosin filaments in the region overlap

18
Q

What are the structural proteins of the sarcomere?

A
  • Titin (connection)
  • Z line protein (alpha-actinic)
  • M-line proteins (myosin, M protein)
  • Nebulin
19
Q

What is a thin filament?

A

Actin filament

20
Q

What is the Sarcoplasm?

A

Intracellular fluid that fills spaces between myofibrils

21
Q

How many thick filaments surround a thin filament?

A

3

22
Q

What is the role of nebulin?

A

Helps to align the actin

23
Q

What gives skeletal muscle its striated appearance?

A

Myofibrils- the orderly arrangements of thick and thin filaments

24
Q

What is a thick filament?

A

Myosin filament

25
Q

Where is the Epimysium?

A

Dense sheath on the surface

26
Q

Describe myosin

A
  • Tail consists of two intertwined heavy chains
  • Two globular heads extend out, forming cross bridges
  • Globular heads contain heavy and light chains and binding sites for acid and ATP (mysosin ATPase)
27
Q

How many thin filaments surround a thick filament?

A

6

28
Q

What are the defining characteristics of skeletal muscle?

A
  1. Multinucleated
  2. Many mitochondria
  3. Transverse tubules
  4. Myofibrils and sarcomeres
  5. Sarcolemma, Sarcoplasm and Sarcoplasmic reticulum
29
Q

Where is the Perimysium?

A

Lies between fasiculi

30
Q

Describe actin

A
  • Contractile protein

* Each G actin has a binding site for myosin