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pha 069 part 2 > SAS 6 > Flashcards

SAS 6 Flashcards

1
Q

What are the most frequent raw materials for semi-solids?

A

Hydrocarbons, Hydrocarbon waxes, Oleaginous substances, Fatty acids and alcohol, Emulsifiers, Polyols, glycerin, sorbitol, Insoluble compounds

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2
Q

What are the factors influencing absorption through the skin?

A

Partition coefficient of the drug substance, Moisture and temperature in the environment of the skin, Pathologic injury to the skin, Vehicle used

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3
Q

These are frequently employed to increase the viscosity of mineral oil to prevent separation from an ointment.

A

Hydrocarbon wax

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4
Q

are used in water-removable creams as an emulsifier to develop a certain consistency in the cream.

A

Stearic acid

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5
Q

are used in creams as AUXILIARY EMULSIFIERS AND EMOLLIENTS.

A

Stearyl and cetyl alcohol

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6
Q

is the most commonly used in ointment vehicles.

A

Petrolatum

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7
Q

are hydrophilic mixtures formed by the addition of substances miscible with hydrocarbons and possessing polar groupings such as SO4, sulfonate, carboxyl hydroxyl, or an ether linage

A

Absorption base

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8
Q
  • An oil-in-water emulsion
  • appears like cream
A

Water removable base

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9
Q
  • A water-in-oil
A

absorption base

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10
Q
  • these are prepared from mixtures of high and low molecular weights polyethylene glycols.
  • a.k.a greaseless ointment
A

water washable base

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11
Q

Anhydrous ointment are prepared by?

A

fusion method

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12
Q

what are the three factors to be controlled during manufacture?

A

time of mixing, temperature, mechanical works including rate of agitation

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13
Q

what are the steps in the manufacture of emulsified semi-solids?

A

preparation of oil and aqueous phases, mixing of the phases, cooling the semi-solid emulsion, homogenization, storage of semi-solids, transfer of material for packaging.

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14
Q

what is the weight of adult and pedia rectal suppository?

A

adult: 2g
pedia: 1g

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15
Q

what is the size of the adult and pedia recal suppository?

A

adult: 32mm
pedia: 16mm

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16
Q

what is the weight of the vaginal suppository?

A

5g

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17
Q

what is the weight of male and female urethal suppository?

A

male: 4g
female: 2g

18
Q

what is the size of male urethal suppository?

A

140mm

19
Q

is a measure of the percentage of fat in the crystalline phase to the total fat across a temperature gradient?

A

Solid-fat index

20
Q

is a measure of unesterified positions of glyceride molecules and reflects the monoglyceride and diglyceride content of a fatty base?

A

Hydroxyl value

21
Q

this value allows prediction of the time required for solidifying the base when it is chilled in the mold.

A

Solidification value

22
Q

this represents the number of mg of potassium hydroxide required to neutralize the free acids and saponify the esters controlled in 1g of fat

A

Saponification value

23
Q

this value expresses the number of grams of iodine that reacts with 100g of fat or other unsaturated material

A

Iodine value

24
Q

the number of milligrams of potassium hydroxide required to neutralize the free acid in 1g of substance is expressed by this value.

A

Acid value

25
Q

most frequently employed suppository base

A

Oleaginous base

26
Q

most common base used for rectal suppository

A

cocoa butter

27
Q

Made from triglycerides from palm, palm kernel and coconut oils.

A

Fattibase

28
Q

Made form triglycerides derived from coconut oil

A

Wecobee

29
Q

Made from triglycerides of saturated fatty acids C12-C18.

A

Witepsol

30
Q

Most frequently used in preparation of vaginal suppositories.

A

Glycerinated gelatin

31
Q

Example of miscellaneous base

A

Polyoxyl 40 stearate

32
Q

Major source of witepsol

A

lauric acid

33
Q

a.k.a macromelting range test

A

Melting range test

34
Q

measures the liquefaction time of rectal suppositories in an apparatus that stimulates IN VIVO CONDITION.

A

Liquefaction

35
Q

this test the rate of IN VITRO release of drug substances from suppositories

A

Dissolution test

36
Q

what is the storage condition of parenterals?

A

2-8C

37
Q

this type of glass are preferred for buffered aqueous solution and dry powders and oleaginous solution

A

Type II Treated soda lime glass

38
Q

this type of glass are preferred for dry powders and oleaginous solutions

A

Type III Soda lime glass

39
Q

this melts sufficient glass AT THE TIP of the ampoule neck

A

Tip sealing

40
Q

this is heats the neck f the rotating ampoule BELOW THE TIP

A

pull sealing

41
Q

a.k.a Tyandallization

A

Fractional method

pha 069 part 2 (8 decks)

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