SBL Pharm Flashcards by Justin McGee

High expression of p-Glycoprotein means what?

Resistance to natural products

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MOA of Alkylating agents?

Cross-linking of DNA

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Cisplatin is what kind of drug?

Alkylating agent

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Tumor cells can become resistant to alkylating agents how?

Increased MGMT, DNA repair enzyme

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Carmustine is good at treating what?

Brain tumors (lipophilic)

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Cyclophosphamide is what kind of drug?

Alkylating agent

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Antimetabolits cause DNA damage during what phase?

S phase

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What is the MOA of Cytarabine?

Converted into ara-CTP and blocks DNA polymerase

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Pemetrexed can cause what side effect?

Painful erythema and swelling of the hands and feet

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What drug is used to rescue from methotrexate?

Leucovorin

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What is the most effective drug for AML?

Cytarabine

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Vincristine can cause what?

Neurotoxicity

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Topotecan and Irnotecan can cause what?

Diarrhea

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What is MOA of anti tumor ABx?

Free radicals

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What is the major SE of doxorubicin?

Cardiac toxicity

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What does doxorubicin inhibit?

Topoisomerase

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What drug causes blue discoloration of fingernails, sclera, and urine?

Mitoxantrone

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Bleomycin has what SE?

Pulmonary toxicity

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What is a common SE of tyrosine kinase and growth factor receptor inhibitors

Acneform skin rash

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Imatinib is an inhibitor of what?

Bcr-Abl

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What is the first line therapy for CML?

Imatinib

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What is the MOA of Ziz-aflibercept

An IgG that is attached to VEGFR

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Cyclophosphamide is used for what?

Non-Hodgkin lymphomas and Burkitt Lymphoma

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Aldophasmide is broken down into what two things?

Phosphoramide mustard and Acrolein

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Acrolein causes what?

Hemorrhagic cystitis

What is the triple therapy used after surgery for breast cancer?

Cyclophosphamide, doxorubicin, and Taxane

What is Mechlorethamine

Used for T cell lymphoma topically

What is the SE of mechlorethamine?

Blistering

What is Melphalan used for?

Multiple Myeloma with dexamethasone

Chlorambucil is only used for what?

Chronic Lymphoblastic Leukemia

Nitrosourease are effective in what kind of cancer?

Brain cancer, lipid soluble

Carmustine what MOA?

Alkylates DNA

What is the SE of Carmustine?

Myelosuppression

MGMT having tumors are immune to what?

Carmustine

What Carmustine used to treat?

Malignant gliomas via wafer

What is Streptozin used for?

Pancreatic islet cell carcinoma

What is the MOA of Streptozin?

Attacks the islets of Langerhans

MOA of Thiotepa?

Causes DNA crosslinks

What is Thiotepa used for?

Used in transplants for hematological malignancies

What is the MOA of procarbazine?

Methylates DNA

Why can Procarbazine not be used as a single agent?

Rapidly occurring resistance due to MGMT being elevated

What is the SE of Procarbazine?

Acute leukemia and can interact poorly with alcohol

What is Procarbazine used for?

Hodgkin and gliomas

Bandamustine MOA?

Crosslinks DNA and inhibits mitotic check points

What is Bandamustine used for?

CLL and NHL

What is the MOA of Platinum analogues?

Bind DNA through crosslinks

Cisplatin must be given with what?

Normal saline to protect kidney

Cisplatin is inactivated by what?

Aluminum

What are the SE of cisplatin?

N/V, peripheral motor and sensory neuropathy and causes myelosuppression as well

Cisplatin is used for what?

Testicular cancer

How does Carboplatin differ for Cisplatin?

Doesn't need IV hydration, less SE

What is Carboplatin used for?

Carcinoma of the ovary

What is the SE of Oxaliplatin?

Neurotoxicity

What is Oxaliplatin used for?

Colorectal and gastric cancer

MOA of methotrexate?

Folic acid analog that binds DHFR

What drugs decrease the renal clearance of methotrexate?

Aspirin, NSAIDS, Penicillin, cephalosporins

What resistance to methotrexate can be caused by what?

Altered DHFR protein, reduced folate carrier or receptor protein

Pemetrexed works on what phase?

S phase

Pemetrexed is used for what?

Mesothelioma, non-small cell lung cancer

What is the SE of Pemetrexed? | What is the Tx?

Hand and foot syndrome, treated with dexamethasone

What is Pralatrexate used for?

Refractory T cell lymphoma

What is 5-Fu used for?

Colorectal cancer

People who are deficient in dihydropyrimidine dehydrogenase have what when they take 5-FU?

Explosive toxicity

Capecitabine is a prodrug for what?

5-Fu

Capecitabine is with what for metastatic colorectal cancer?

Capecitabine and oxaliplatin

What two drugs are a part of TAS-102

Trifluridine and tipiracil

TAS-102 is used to treat what?

Mutant RAS colorectal cancer

What are the two deoxycytidine analogs?

Cytarabine and Gemcitabine

What is Cytarabine used for?

hematologic malignancies

What is Gemcitabine viable against

Solid tumors and hematologic cancer

6-mercaptopurine is metabolized by what?

HGPRT

6-mercaptopurine is used for what?

childhood acute leukemia

What cannot be given with 6-mercaptopurine?

Allopurinol

6-thioguanine is used with what?

Cytarabine

Fludarabine is used for what

NHL, CLL

What is the MOA of Fludarabine?

Interferes with DNA polymerase

What is the SE of Fludarabine?

Potent immunosuppressant, risk of Jiroveci

Cladribine has what SE?

immunosuppressive

Vinca Alkaloids have what MOA?

Inhibit tubular polymerization leading to arrest in metaphase

Vinblastine has what side effect?

Blistering

What class are Vinblastine, Vincristine, and Vinorelbine?

Vinca alkaloids

Vincristine has what SE?

Neurotoxicity and SIADH

-Taxel means what. MOA?

Attack microtubules, similar to Vinca Alkaloids

Cabazitexal is good for drug-resistant tumors, why?

Poor substrate for P-glycoprotein

Which Taxel inhibits microtubules?

Ixabepilone

Eribulin MOA?

Inhibits microtubule function leading to block in G2-M

Eribulin is approved for what cancer?

Metastatic breast cancer

Etoposide MOA?

Forms a complex with topoisomerase leading to inhibition of DNA synthesis

What major SE can camptothecins cause?

Early and late form diarrhea

-tecan what MOA?

camptothecins, inhibit topoisomerase I

Irontecan is a prodrug for what?

SN-38, more potent topo inhibitor

Anthracyclines consist of what?

Doxorubicin, daunorobicin, idarubicin, epirubicin, mitoxantrone,

Anthracyclines MOA?

Inhibition of Topo and generation of free radicals

Idarubicin combined with cytarabine is used for what?

AML

Mitozantrone MOA?

Binds to DNA to produce strand breakage

What does mitomycin treat?

SCC of the anus with 5-FU

Bleomycin has what toxicity?

Pulmonary

Where are tyrosine kinase inhibitors metabolized at?

Liver, by CYP3A4

-tinib MOA?

Tyrosine kinase inhibitors

Imatinib is the first line treatment for what?

CML

Dasatinib is used for what?

CML that is resistant to imatinib

Niltinib and Basutinib are used for what?

CML that is resistant to imatinib

GFR inhibitor MOA?

Inhibits EGFR and VEGF

Cetuximab MOA?

Monoclonal antibody directed against EGFR

Erlotinib is metabolized by what?

CYP3A4

Osimertinib has what SE?

QT prolongation and cardiomyopathy

Bevacizumab targets what?

VEGF-A

Zic-afibercept has what SE?

HTN/thombo/GI/Proteinurea

Sorafenib can cause what?

Hand-foot syndrome

SBL Pharm Flashcards

(109 cards)