Schildklierfysiologie Flashcards

1
Q

NIS transporter

A

Jodium uit bloed cel in

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2
Q

Pendrine

A

Jodium uit cel colloid in

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3
Q

TPO

A

Oxidatie jodium en binding jodium aan tyrosine in colloid, daarna binding MIT en DIT aan TG

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4
Q

Deodinase 1

A

Lever, nier en schildklier

T4 –> T3

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5
Q

Deodinase 2

A

Brein, hypofyse, long, placenta

T4 –> T3

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6
Q

Deodinase 3

A

Afbraak T4 en T3

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7
Q

Klachten hyperthyreoidie

A
Hartkloppingen
Osteoporsoe
Gewichtsverlies
Trillen, slapeloosheid
Klamme huid
Spierpijn en zwakte
Diarree
Excessief zweten
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8
Q

M. Graves

A

Primaire hyperthyreoidie
Stimulerende TSH autostoffen (aantoonbaar in bloed)
Verdikking oogspieren, uitpuilende ogen

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9
Q

Toxische nodus

A

Primaire hyperthyreoidie

Autonome productie T3 en T4

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10
Q

Thyreoiditis

A

Primaire hyperthyreoidie
1. Cellen kapot door infectie, T3,T4 lekt > TSH omlaag
2. Voorraden T3,T4 niet aangevuld > TSH omhoog
Keelpijnklachten

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11
Q

TRH/TSH producerende tumor

A

Secundaire hyperthyreoidie

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12
Q

Hypofyseadenoom

A

Secundaire hyperthyreoidie
Oogklachten
Hoofdpijn

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13
Q

Klachten hypothyreoidie

A
Bradycardie
Traagheid
Droge huid
Broze nagels
Haarverlies
Spierpijn
Gewichtstoename
Koude-intolerantie
Obstipatie
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14
Q

Hashimoto

A

Primaire hypothyreoidie
Meest voorkomende oorzaak
Anti-stoffen TPO

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15
Q

Dopamine

A

Afgegeven door hypothalamus

Remt prolactine afgifte hypofyse

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