schizo

Question 1

What agents have high risk of QT prolongation?

Answer 1

chlorpromazine
thioridazine
haloperidone
ziprasidone
iloperidone

Question 2

What agents have high metabolic risk?

Answer 2

olanzapine
clozapine
risperidone
paliperidone
quetiapine

Question 3

What agents should you use if metabolic risk is a concern?

Answer 3

aripiprazole
ziprasidone
lurasidone
asenapine

Question 4

What agents lower seizure threshold?

Answer 4

clozapine
chlorpromazine

Question 5

What agents may cause insomnia?

Answer 5

aripiprazole, brexpiprazole

Question 6

What agents may cause dizziness?

Answer 6

asenapine
iloperidol
brexpiprazole
cariprazole

Question 7

What agents may cause impulsivity?

Answer 7

aripiprazole

Question 8

What agents are prolactin-elevating?

Answer 8

FGAs
risperidone
paliperidone
olanzapine

Question 9

What agents have anticholinergic effects?

Answer 9

chlorpromazine
thioridazine (highest)
clozapine
olanzapine

Question 10

What agents have highest EPS?

Answer 10

haloperidol
fluphenazine

Question 11

At high doses, which SGAs have EPS?

Answer 11

risperidone
paliperidone

Question 12

Smoking has drug interaction with

Answer 12

olanzapine
clozapine
(reduces levels via CYP1A2)

Question 13

Antacids have drug interaction with

Answer 13

(reduce absorption of) chlorpromazine

Question 14

What has interactions with olanzapine-samidorphan?

Answer 14

3A4, 1A2, opioid withdrawal/dependence

Question 15

What has interactions with lumateperone?

Answer 15

3A4

Question 16

risperidone LAI frequency

Answer 16

2 weeks

Question 17

paliperidone (Invega Sustenna) LAI frequency

Answer 17

1 month

Question 18

paliperidone (Invega Trinza) LAI frequency

Answer 18

3 months

Question 19

paliperidone (Invega Hafyera) LAI frequency

Answer 19

6 months

Question 20

aripiprazole (Abilify Maintena) LAI frequency

Answer 20

1-2 months

Question 21

aripiprazole (Aristada) LAI frequency

Answer 21

1-2 months

Question 22

haloperidol decanoate LAI frequency

Answer 22

1 month

Question 23

fluphenazine decanoate LAI frequency

Answer 23

2 weeks

Question 24

olanzapine LAI frequency

Answer 24

2-4 weeks

Question 25

What agents are available as OROS capsules?

Answer 25

paliperidone (once a day)

Question 26

What agents are available as ODT?

Answer 26

aripiprazole olanzapine risperidone

Question 27

What agents are available as sublingual tablets?

Answer 27

asenapine

Question 28

What agents are available as transdermal patches?

Answer 28

asenapine

Question 29

What agents are available as liquids?

Answer 29

aripiprazole haloperidol fluphenazine risperidone

Question 30

What agents should be taken with food? Minimum calories?

Answer 30

ziprasidone, 500 calories lurasidone, 350 lumateperone

Question 31

What agents can cause somnolence?

Answer 31

asenapine iloperidone lurasidone lumateperone cariprazine

Question 32

Which agent is contraindicated to acute respiratory s/s, asthma, COPD or other lung disease associated with bronchospasm?

Answer 32

loxapine

Question 33

Which agent is available as an oral inhalation powder?

Answer 33

loxapine

Question 34

Which agent may cause blue/gray discoloration of skin?

Answer 34

chlorpromazine

Question 35

What can be used to treat acute dystonia?

Answer 35

benztropine diphenhydramine

Question 36

What can be used to treat akithisia?

Answer 36

propanolol clonidinep

Question 37

What can be used to treat pseudoparkinsonism?

Answer 37

benztropine ropinirole

Question 38

What can be used to treat tardive dyskinesia?

Answer 38

valbenazine deutetrabenazine

Question 39

What is the MoA of valbenazine and deutetrabenazine?

Answer 39

VMAT2 inhibitor

Question 40

Neuroleptic malignant syndrome is a warning for which EPS medications?

Answer 40

deutetrabenazine

Question 41

What should you do for a patient who is experiencing EPS on an antipsychotic agent?

Answer 41

Reduce dose OR switch to other agent with lower risk of EPS

Question 42

What may a patient experience during neuroleptic malignant syndrome?

Answer 42

Hyperthermia, confusion, stupor, diaphoresis, tachycardia, increase CPK and muscle rigidity

Question 43

How should you treat a patient experiencing neuroleptic malignant syndrome?

Answer 43

D/C antipsychotics use dantrolene, BZDs, or dopamine agonists

Question 44

Neuroleptic malignant syndrome is more likely to occur when:

Answer 44

-a patient is taking typical antipsychotics -after high dose IM injections -after recent initiation

Question 45

Difference between FGA and SGA mechanism of action?

Answer 45

Both D2 antagonists Only SGAs are partial serotonin receptor antagonists

Question 46

Which agent may cause excessive drooling?

Answer 46

clozapine

Question 47

Which agent has a BBW on neutropenia and myocarditis?

Answer 47

clozapine

Question 48

What is the MoA of samidorphan?

Answer 48

mu-opioid receptor antagonist kappa-/delta-opioid receptor partial agonist

Question 49

What are contraindications to olanzapine-samidorphan?

Answer 49

opioid use or acute opioid withdrawal

Question 50

What agent should not be used in end-stage renal disease?

Answer 50

olanzapine-samidorpan

Question 51

Which LAI has a BBW for severe sedation/coma?

Answer 51

olanzapine (Zyprexa Relprevv)

Question 52

Which agent can cause rare but serious skin reactions? (DRESS)

Answer 52

olanzapine-containing agents

Question 54

what agents are prolactin sparing

Answer 54

clozapine quetiapine ziprasidone aripiprazole