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NCM117 LEC > Schizo meds > Flashcards

Schizo meds Flashcards

1
Q

Mgt of Schizo

A

*Brief hospitalization of psych unit
*Adm of neuroleptics
*Milieu mgt
*Supportive therapy
*Psycho ed for fam
*Discharge planning

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2
Q

Antipsychotics

A

Typical AP
Atypical AP
Dopamine system stabilizer

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3
Q

It blocks selected dopamine receptors in the STRIATAL and LIMBIC areas in the brain, an action believed to reduce psychotic symptoms.

A

Typical AP agents

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4
Q

Typical AP affects

A

Histamine, serotonin, nor epi and acetylcholine

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5
Q

Does tolerance develops in typical ap?

A

NO

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6
Q

When should we give Typical AP agent

A

2 hrs po. Not taken with antacids of H2 blocking agents (Cimetidine)

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7
Q

Long acting prep for typical AP

A

Haloperidol and Fluphenazine (Prolixin). IM via depot inj, lasts 2-4 weeks

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8
Q

Contraindications for Typical AP

A

Known allergic response to any antipsychotic
CNS depression
Parkinson’s disease
Blood dyscrasias
Hepatic disease
Acute narrow-angle glaucoma
Benign prostatic hypertrophy

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9
Q

Examples of Typical AP

A

Fluphenazine (Prolixin)
Haloperidol (Haldol)
Chlorpromazine (Thorazine)
*ZINE, DOL, FON, MRIL

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10
Q

It blocks the dopamine receptors in the LIMBIC system and affect SEROTONIN receptors in the CORTICAL brain areas

A

Atypical AP agents

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11
Q

More advantages than Typical AP

A

Atypical AP

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12
Q

Reduces positive symptoms only

A

Typical, more side effects

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13
Q

Reduces both Positive and negative symptoms

A

Atypical AP

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14
Q

Decreases EPS or no EPS

A

Atypical

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15
Q

Does not affect dopamine in the striatal areas

A

Atypical

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16
Q

Atypical rapid dissolving prep:

A

Olanzapine (Zyprexa), Risperidone (Risperdal)

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17
Q

Atypical AP examples

A

Clozapine (Clozaril)
Olanzapine (Zyprexa)
Risperidone (Risperdal)
*PINE, DONE, CRIL, PREXA, QUEL, DAL, DON

18
Q

RESTORES DOPAMINE activity in the CORTICAL levels of the brain and REDUCE dopamine in the LIMBIC areas, thus decreasing psychotic symptoms

A

Dopamine System stabilizer

19
Q

Has common side effects

A

DSS

20
Q

Drug under DSS

A

Aripiprazole- Abilify

21
Q

Common side effects of Psychotropic drugs

A

*Anticholinergic effects
*Cardiovascular effects
*CNS
*GI
*Endocrine

22
Q

Anticholinergic effects

A

*Dry mouth: sugar less bbg, rinse mouth freq.
*Blurred vision: eye pain=narrow angle glaucoma
*urinary retention
*constipation

23
Q

Cardiovascular effects

A

*Postural Hypotension: change position slowly
*Arrythmias: report sensation of racing pulse

24
Q

CNS

A

*Headache
*Drowsiness, dec mental alert
*TAKEN HS OD

25
Q

GI

A

*Nausea, dec appetite: take with full stomach
*Wt. gain, inc app: take enough cal

26
Q

Endocrine effects

A

*Amenorrhea
*Gynecomastia
*Sexual dysfunction: Anorgasmia in W and Erectile dys in men

27
Q

Extra Pyramidal Effects of Psychotropic drugs

A

*Pseudo parkinsonism
*Acute dystonic reaction
*Akathisia
*Tardive Dyskinesia

28
Q

Pseudo parkinsonism

A

*Drooling
*Motor retardation (akinesia)
*Lack of facial expression
*shuffling gait
*fine tremors (pill-rolling)

29
Q

Treatment for pseudo p

A

Antipsychotics + anticholi, congentin, artane

30
Q

Acute dystonic reaction

A

*muscle spasm of jaw, tongue, neck, or eyes
*laryngeal spasm
*Oculogyric crisis- backward rolling of eyes

31
Q

Treatment for Acute dystonic reaction

A

*Stop drug, adm antidote (congentin, benadryl)

32
Q

Akathisia

A

*motor restlessness
*state of moving
*diff. of sitting still
*strong urge to move

33
Q

treatment for akathisa

A

*Adm antiparkinsonian drug
*Reduce antipsychotic dose

34
Q

Tardive Dyskinesia

A

*Serious, irreversible
*involuntary movements, mouth, tongue, and face
*grinding teeth, lip smacking

35
Q

Serious side effects of Psychotic drugs

A

*Agranulocytosis
*Seizures
*Hepato toxicity
*Neuroleptic malignant syndrome

36
Q

decrease white blood cells characterized by sore throat, low grade fever, malaise, mouth sores

A

Agranulocytosis

37
Q

treatment for agranulocytosis

A

*Stop the drug
*reverse isolation
*monitor cbc

38
Q

Kind of seizure in serious effects

A

tonic cloning seizures: give anticonvulsants

39
Q

abnormal liver function series (elevated enzymes), fever, nausea, jaundice and abdominal pain

A

Hepato toxicity: bed rest, good nutrition, adeq fluids

40
Q

Neuroleptic malignant syndrome

A

*Altered consciousness
*severe hyperthermia (38.9)
*Diaphoresis
*Tachycardia, Massive dopamine blockage in brain

41
Q

Treatment for neuroleptic malignant syndrome

A

*Stop drug
*check vs
*adm dopamine receptors stimulator: Bromocriptine (Parlodel)
*Adm, iv fluids, hypothermia measures

NCM117 LEC (18 decks)

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