Schizophrenia Flashcards

(45 cards)

1
Q

Definition of Schizophrenia

A

Severe mental disorder where contact with reality and insight are impaired, an example of psychosis

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2
Q

Difference between Type 1 Acute Schizophrenia & Type 2 Chronic Schizophrenia

A

Acute: Obvious positive symptoms appear suddenly after stressful events
Chronic: Illness takes many years to form and gradual changes of withdrawal and increased disturbance. Characterised by negative symptoms.

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3
Q

Types of schizophrenia according to ICD-10

A
  • Disorganised: Delusions, hallucinations, incoherent speech and mood swings
  • Catatonic: Immobility, rocking
  • Paranoid: Delusions
  • Undifferentiated: Not fitting into other categories
  • Residual: Had it in the past
  • Simple Schizophrenia: Negative symptoms, no delusions
  • Post Schizophrenia depression
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4
Q

Criterion A for DSM-V

A

Need two or more of: Delusions, Hallucinations, Disorganised Speech, Catatonic behaviour, Negative Symptoms.
Only one of the criteria may be present if the delusion/hallucinations are bizarre and extreme.

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5
Q

Criterion B (Social/occupational dysfunction) for DSM-V

A

Since the onset of schizophrenia, one or more areas of functioning will be negatively affected, e.g. work/interpersonal/self-care

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6
Q

Criterion C (Duration) for DSM-V

A

Continuous signs of disturbance will be present for 6 months or more.
Symptoms from criterion A must be present for one month. During non-active periods, disturbance might be limited to negative symptoms only, or two or more symptoms from criterion A.

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7
Q

What does DSM-V stand for and when was it updated?

A

Diagnostic Statistical Manual 5th Edition, May 2013

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8
Q

What does ICD-10 stand for and when was it published?

A

International Classification of Diseases 10th edition,, 1992

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9
Q

Define ‘positive symptoms’ of schizophrenia

A

Excesses, symptoms that have been added to the patient’s personality because they now have the illness of schizophrenia. E.g. hallucinations, delusions, disorganised speech

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10
Q

Define ‘negative symptoms’ of schizophrenia

A

Reduction/loss of normal functioning. The person loses the ability to do certain things because of the illness. E.g. speech poverty, avolition, apathy

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11
Q

When does reliability in diagnosis and classification of schizophrenia occur?

A

When the ICD-10 and DSM-V show a good consistency of diagnosis of schizophrenia over a period of time and between different psychologists (inter-rater reliability).

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12
Q

Why is the DSM-V more reliable than the ICD-10?

A

The symptoms for schizophrenia in DSM-V are outlines for each category and are more specific.

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13
Q

Hoe has the classification and diagnosis of schizophrenia improved in validity and reliability over time?

A

The DSM-V and ICD-10 are updated every few years.

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14
Q

What does validity mean in relation to the classification and diagnosis of schizophrenia?

A

This means that a diagnostic system (ICD/DSM) assesses what it claims to be assessing (schizophrenia). If the DSM and ICD are valid we can be confident that the patient diagnosed has schizophrenia and not another.

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15
Q

What is content validity?

A

The extent to which an assessment covers the range of symptoms of schizophrenia. E.g. interviews/checklist that covers all the symptoms

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16
Q

What is co-morbidity?

A

This refers to the extent that two or more illnesses occur simultaneously in a patient. This is an important validity issue when classifying & diagnosing schizophrenia.

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17
Q

Describe some research/facts that support co-morbidity.

A
  • A psychologist states that 1% of the population will suffer from schizophrenia and 2.5% from OCD. However, 12% of schizophrenic patients meet the diagnostic criteria to also be suffering from OCD (co-morbid). This causes the problem of classifying the illness as schizophrenia, and not another psychological illness.
  • Boundaries between schizophrenia and mood disorders are blurred as they share many symptoms
  • Depression (mood disorder) is co-morbid (occurs alongside) schizophrenia.
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18
Q

How to give correct and valid diagnosis in the case of co-morbidity?

A

Psychologist should do a full consultation using the DSM and ICD in order to get the correct and valid diagnosis.

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19
Q
  • Evaluation of co-morbidity
A
  • DSM and ICD can be seen as lacking validity because there is too much overlap between schizophrenia, mood disorders and OCD. Clinicians might diagnose a patient as having depression and schizophrenia or they may seek a second opinion to get around the problem.
  • Diagnosis can be invalid and unreliable. 32% of 142 hospitalised schizophrenic patients were co-morbid.
  • Schizophrenic patients have used alcohol, cannabis and cocaine and suffer from substance abuse before diagnosis. This makes it difficult to give a reliable and valid diagnosis.
  • Psychologist found that schizophrenic patients with co-morbid illnesses were often excluded from research, but the majority of patients suffer with other psychological illnesses. Research findings cannot be generalised and are invalid.
20
Q

Luhrmann’s research that found auditory hallucination can be influenced by culture. How? (reliability)

A

60 adults with schizophrenia (20 from Ghana, 20 from India and 20 from USA) were interviewed. All the patients reported they heard voices but the patients from USA reported the most negative experiences with the voices, e.g. the voices were violent and harmful. Therefore culture has an influence on the reliability of diagnosing schizophrenia.

21
Q

Cochrane (1977) investigation into culture bias in classifying and diagnosing schizophrenia

A

West Indies and Britain had a prevalence rate of 1%. Afro-Caribbean people living in Britain were 7 times more likely to be diagnosed with schizophrenia than a white patient. This means either Afro-Caribbean people have more stressors that cause schizophrenia, or their diagnosis of schizophrenia was invalid due to culture bias.

22
Q

+ Evaluation of Culture Bias

A

+ Research evidence has found support for cultural relativism. Afro-Caribbean ppl have little immunity to flu, and children born to mothers who had flu when they were pregnant in their second trimester, have an 88% increased chance of developing schizophrenia. There might be a cultural vulnerability which means Afro-Caribbean’s might be more at risk from developing schizophrenia than the white population.
+ The Ethnic Culture hypothesis predicts that ethnic minorities experience less distress if they suffer with the illness of schizophrenia, because they have protective characteristics and social structures that exist in their culture. 184 individuals with schizophrenia were investigated from African American, Latino or White American cultures. It was found that Americans had more symptoms than the other 2 cultures because they had less protective and supportive features in their culture (social support)

23
Q
  • Evaluation for culture bias
A
  • Cochrane (1995) found research evidence to suggest that diagnosing schizophrenia can be invalid for immigrants. Clinicians might wrongly attribute the diagnosis of schizophrenia to ethnicity, rather than to the stressors that have occurred in the patient’s life. This is connected with labelling, whereby some clinicians wrongly label immigrants with a mental disorder which is invalid (misdiagnosis).
  • Cultural relativism. Psychologists may not understand the patient’s symptoms correctly due to not understanding their cultural background - can lead to incorrect judgements and misdiagnosis. E.g. ppl from African backgrounds would be seen as gifted in their culture if they say they heard the voice of God but in western countries this would be seen as auditory hallucination.
24
Q

Gender bias (validity): Differences between genders

A
  • Male sufferers tend to show more negative symptoms and suffer more from substance abuse
  • Males have an earlier onset (18-25) years than females (25-35 years) and different peak ages (21 & 39 for men and 22, 37 and 62 for women)
  • Accuracy can vary due to clinicians having stereotypical beliefs about gender.
  • Critics of DSM argue that healthy adult behaviour is linked more to healthy males than females. The DSM can be viewed as gender biased.
25
- Evaluation of Gender Bias
- Loring (1985) gave 290 male and female psychologists case studies of patients to read (one male and one female). Psychologists had to diagnose the patients. When patient was male, or no info as given about gender, 56% of psychologists diagnosed them as schizophrenic. When female, 20% of psychologists diagnosed schizophrenia. This gender bias was more prominent when the psychologist was male. Invalid diagnosis. - Females develop schizophrenia 4-10 years later than males. There are different types of schizophrenia that males and females are vulnerable to and this much be taken into account when diagnosing and classifying the illness.
26
+ Evaluation for Gender Bias
+ Kulkarni (2009) found that females might be less vulnerable than males to schizophrenia. He found the female sex hormone oestradiol can help treat schizophrenia in females, especially when added to anti-psychotic drugs). This must be taken into account when diagnosing schizophrenia, especially in females, in order to ensure a valid diagnosis.
27
Symptom Overlap (Validity)
Some of the symptoms of schizophrenia can also be found in other disorders such as depression and bipolar disorder. This can affect validity of diagnosis. Ross (1995) found that patients who had Dissociative Identity Disorder had so many symptoms that overlapped with schizophrenia that they could have been diagnosed with schizophrenia.
28
+ Evaluation of Symptom Overlap
+ Clinicians should conduct a brain scan or EEG. Schizophrenic patients tend to suffer from a deterioration of grey matter. Patients who have bipolar depression do not have a reduction in grey matter. This can increase validity of diagnosis.
29
- Evaluation of Symptom Overlap
- Ketter (2005) found evidence of schizophrenia being misdiagnosed as another illness: misdiagnosis. This causes years of delays, whereby schizophrenic patients do not receive correct treatment, and their illness gets worse. This can increase suicide rates and deterioration. - Inter-rater reliability is low. Beck (1961) studied 154 patients who met two psychiatrists. Inter-rater reliability was 54%, which means different psychiatrists give different diagnosis. Reliability is low.
30
Genetics study: Ripke et al (2014) - AO1 content
- Suggested schizophrenia might be polygenic: a number of candidate genes are responsible - Meta-analysis of studies - 37,000 schizophrenia sufferers were compared to 11,000 controls. - 108 separate genetic variations were associated with increased risk of getting schizophrenia - These genes coded for dopamine - High levels of dopamine can cause schizophrenia
31
- Evaluation of Ripke's study
- Genetics alone may not cause schizophrenia. E.g. the behavioural model may suggests children can learn abnormal behaviours via the environment - Does not offer a full explanation as to how schizophrenia is transmitted. Just because someone has the gene doesn't mean they will get the illness (e.g. the gene could be recessive). The diathesis stress model takes into account genetics and environmental factors. - Sometimes schizophrenia can occur in the absence of genetics or family history. A mutation in parental DNA can cause schizophrenia. There is also a positive correlation between the parental age of fathers and the risks of having a schizophrenia child. 0.7% if father is under 25yrs and 2% if over 50yrs.
32
+ Evaluation for Ripke's study
+ A lot of reearch support from Gottesman, Katy and many other psychologists which makes the evidence robust and strong to ignore. + Can be supported by the dopamine hypothesis which states that high levels of dopamine in the D1 and D2 receptors in brain can cause schizophrenia. Ripke's work links two biological mechanisms that can cause schizophrenia: genetics and dopamine production. His research provided valuable support for the biological approach/model.
33
Gottesman and Shields study on twins and schizophrenia
- 224 sets of twins from 1948-1993 (longitudinal study of 25 years). 106 sets were MZ and 118 were DZ. One twin had schizophrenia. Average age = 46 and range of different ethnicities. - In depth interviews, doctors case notes and the DSM - 48% of MZ twins were both concordant for schizophrenia by the end - 17% of DZ twins were both concordant by the end - Indicates that schizophrenia has a genetic bases to some extent, more for MZ twins than DZ twins
34
+ Evaluation of Gottesman and Shield's study
+ Longitudinal. Patients could be tracked over long periods of time to see if they get illness, which is very valuable. + Supports the biological (genetics) approach, especially as the chances of getting schizophrenia is 1% for the general population. + Both reliable and valid. 3 different methods used which would have more chance of high inter-rater reliability and high validity. Gives research more credibility and strength.
35
- Evaluation of Gottesman and Shields study
- Ignores behavioural approach. The healthy twin could have modelled or copied schizophrenic behaviour rather than getting it through genetics. - Schizophrenic patients often have difficulty with their speech and communication, and could have found it difficult to correctly relay their symptoms. Interviewing patients is a problem but could be improved by having a range of interviewers who could correlate their findings.
36
What is dopamine and what does it do?
Dopamine is a neurotransmitter. In high amounts it increases motivation, excitation and pleasure.
37
Assumptions of dopamine hypothesis
1. Schizophrenia sufferers have more dopamine receptors in the brain = increase in dopamine 2. D1 and D2 receptors investigated. Schizophrenics had high ratios of dopamine. 3. Anti-psychotic drugs, e.g. phenothiazines, can block activity in dopamine receptors and minimise positive symptoms (only). 4. Drug L-dopa increases dopamine levels (e.g. for Parkinson's disease sufferers). The side effect is that it can cause schizophrenic symptoms.
38
What did Davis and Neale base the dopamine hypothesis on?
- Post-mortem studies have found schizophrenic patients have an increased amount of dopamine receptors and dopamine in the left amygdala of the brain. - Dopamine metabolism in schizophrenic patients' seems abnormal & this can be monitored by PET scanning - Hypothesis can be linked to a fault in genes which causes dopamine levels to increase dramatically.
39
+ Evaluation of Dopamine Hypothesis
+ Great deal of research to support. Davidson found that when schizophrenic patients were given L-Dopa their schizophrenic symptoms got worse. + A lot of scientific evidence and support. Most evidence from brain scans (PET and fMRI) which is highly valid and reliable.
40
- Evaluation of Dopamine Hypothesis
- Cause and effect not clear. Does increase in dopamine cause schizophrenia or does schizophrenia develop first and causes dopamine levels to increase? PET scanning may help in this. - Dopamine is also associated with mania and the illness is not alleviated by phenothiazine drugs. Dopamine seems to have a complex role in the brain and might be associated with many illnesses not just schizophrenia. - Reductionist. There might be other factors or causes e.g. neuroanatomy of brain.
41
Neural Correlates
Schizophrenia might develop due to structural and functional brain abnormalities. We now use fMRI while patients are given cognitive and memory tasks to do. This is compared with normal healthy patients.
42
Swayze's Study
Examined brain imaging using MRI of 50 studies of schizophrenic patients
43
What structural abnormalities did Swayze find in the patients' brain?
Decrease in brain weight; enlarged ventricles (filled with water); smaller hypothalamus; less grey matter; structural abnormalities in pre-frontal cortex
44
+ Evaluation of Neural Correlates
+ Strong amount of supporting evidence that schizophrenia is cause by neural correlates changing in the brain during pre-natal development in womb. + Great deal of supporting evidence that neural correlates is an important factor when looking at cause of schizophrenia e.g. research by Swayze, Allen, Juckel have all said there are problems with brain functioning/structure
45
- Evaluation for Neural Correlates
- Does not explain why schizophrenia occurs in early adulthood and not infancy. Weinberger (1987 stated that the pre frontal cortex develops during adolescence and damage to this area can only be noticed during adolescence/ early adulthood - Andreason (1982) found that the extent to which the ventricles are enlarged is not significant and there is little difference in neural correlates. - Cause and effect needs to be established. - Davison and Neale have found contradictory evidence to suggest that enlarged ventricles are also found in maina sufferers. So they cannot cause schizophrenia but could be vulnerability factor that increases the risk of getting the illness. Diathesis stress model?