Schizophrenia Flashcards
(40 cards)
Classification of Schizophrenia
- collection of unrelated symptoms
2 major systems of classification:
* International Classification of Disease (ICD-11) (UK)
* Diagnostic and Statistical Manual (DSM-5) (USA)
Differences in the classification of Schizophrenia
ICD-11 two or more negative symptoms, for one month or longer, are sufficient for diagnosis (e.g. avolition and speech poverty),
where as in the DSM-5 one positive symptom must be present, for at least one month, for diagnosis (e.g. delusions, hallucinations).
The ICD-11 also recognises subtypes of schizophrenia e.g. Paranoid schizophrenia is characterised by powerful delusions and hallucinations whereas catatonic schizophrenia involves problems with a patient’s movement e.g. they may be immobile for long periods of time.
However, the DSM-5 does not categorise schizophrenia further into sub-types.
Positive Symptoms
An additional experience beyond those of ordinary existence
Hallucinations:
auditory hallucinations (hearing voices that are not present ) or visual hallucinations (seeing objects that are not present).
Delusions:
Irrational beliefs that have no basis in reality, they can make people with schizophrenia behave in ways that make sense to them but may be bizarre to others.
Delusions of persecution - a false belief you are being harassed e.g. by the government.
Delusions of control – a false belief that you are being controlled by something external e.g. by aliens.
Negative Symptoms
A loss of usual abilities and experiences
Avolition:
Severe loss of motivation to carry out everyday tasks and difficulty to begin or keep up with goal-directed activity.
Andreason (1982) identified three signs of avolition; poor hygiene and grooming, lack of persistence in work or education and lack of energy.
Speech poverty:
A reduction in the amount and quality of speech, this is sometimes accompanied by a delay in the sufferers verbal responses
Diagnosis Definition
identification of the nature of an illness by examination of the symptoms
Classification Definition
action of classifying something: the classification of disease according to symptoms
Reliability and validity in diagnosis and classification of schizophrenia
Reliability refers to consistency. whether we can gain consistent results when classifying and diagnosing Sz. Extent to which different classification systems agree upon how schizophrenia should be classified and extent to which two or more health professionals would agree on the same diagnosis, regardless of time period or culture, measured by inter-rater reliability.
Validity refers to accuracy, the extent to which we are measuring what we intend to measure (schizophrenia). For example, are the classification systems accurately outlining the signs and symptoms of schizophrenia and are health professionals’ accurately diagnosing schizophrenia?
Cheniaux research into reliability and validity in diagnosis and classification of schizophrenia
Cheniaux asked two psychiatrists to diagnose same 100 patients using the DSM and ICD. One psychiatrist diagnosed 26 according to DSM and 44 according to ICD. The other diagnosed 13 according to DSM and 24 according to ICD. This shows poor inter-rater reliability as one psychiatrist diagnosed almost double the amount than the other psychiatrist. Moreover, it demonstrates poor reliability in the classification of schizophrenia as both psychiatrists diagnosed almost double the number of patients using the ICD than the DSM, which also calls in to question the validity of the diagnosis
Symptom overlap
where two or more conditions share similar symptoms. For example, both schizophrenia and depression involve negative symptoms such as avolition
Co-morbidity
where two conditions occur at the same time. Schizophrenia is commonly diagnosed with other conditions such as depression as they share common symptoms
Gender/ Culture Bias
Gender bias - Since the 1980s men diagnosed with schizophrenia more often than women.
Culture bias - English people of African origin are much more likely to be diagnosed with schizophrenia in the UK
Reliability and validity in diagnosis and classification of schizophrenia AO3
:( One problem of reliability and validity of the classification and diagnosis of schizophrenia is that there is often ‘Symptom overlap’. This is where two or more conditions share similar symptoms. For example, both schizophrenia and depression involve negative symptoms such as avolition. This questions the validity and reliability of the classification and diagnosis of schizophrenia because an individual may be diagnosed with the wrong disorder. This is an issue as doctors may not be diagnosing schizophrenia correctly, and therefore individuals may not receive appropriate treatment. This weakens the validity and reliability in the classification and diagnosis of schizophrenia as it negatively affects its accuracy and consistency
:( A further problem with the reliability and validity of the diagnosis and classification of schizophrenia is ‘Co-morbidity’. This is where two illnesses/conditions occur at the same time. For example, Buckley et al (2009) concluded that 50% of patients diagnosed with schizophrenia also have a diagnosis of depression and 23% of patients diagnosed with schizophrenia are diagnosed with OCD. This questions the validity and reliability of classification and diagnosis of schizophrenia, because the two conditions may be better seen as one and doctors may diagnose the wrong condition.
:( Moreover, another issue with the validity of the diagnosis and classification of schizophrenia is Gender bias in diagnosis. Since the 1980s men have been diagnosed with schizophrenia more often than women. This may be because men are more genetically vulnerable to developing schizophrenia than women. However, it could be because females with schizophrenia typically function better than men, being more likely to work and have good family relationships therefore their symptoms may be masked by good interpersonal skills (Cotton et al). This questions the validity and reliability of the classification and diagnosis of schizophrenia as women who share similar symptoms as men may not receive the same diagnosis as their symptoms seem mild.
:( A final problem with the classification and diagnosis of schizophrenia is cultural bias. English people of African origin are much more likely to be diagnosed with schizophrenia in the UK. This is attributed to some Afro-Caribbean societies view hearing voices as communication from ancestors whereas in the UK this behaviour would be associated with positive symptoms of schizophrenia. Therefore, resulting in Afro- Caribbeans living in the UK being ten times more likely to receive a diagnosis for schizophrenia compared to white Britons. Professionals may not understand the norms and behaviours in other cultures so may lead to wrong diagnosis, limiting reliability/ validity in classification and diagnosis of schizophrenia.
Biological explanation- Genetic theory
schizophrenia is hereditary and passed on from one generation to the next through genes. Therefore, a person is born with a genetic predisposition to schizophrenia. It is believed that several maladaptive ‘candidate’ genes such as PCM1, are involved (polygenic) which increases an individual’s vulnerability to developing schizophrenia. Studies have shown that 108 separate genetic variations are associated in the risk of developing schizophrenia.
Gottesman (1991) studied 40 twins and found that the concordance rate for monozygotic twins was 48% and only 17% for dizygotic twins. Therefore, the closer the genetic link to somebody with schizophrenia, the more chance of developing schizophrenia.
Genetic theory – AO3
:) Research to support the role of genetics in the development of schizophrenia comes from Tierney. He studied 155 adopted children who had biological mothers with schizophrenia and found that they had a concordance rate of 10% compared to 1% in adopted children without schizophrenic parents. This provides significant support for the role of genetics as an explanation of schizophrenia as the role of Social Learning Theory could not have been a factor as the children were adopted
Biological explanation- Neural correlates: Brain Structure or Function
One neural correlate of schizophrenia is enlarged ventricles. A meta-analysis by Raz and Raz found that over half of individuals tested, with schizophrenia had increased ventricle size compared to a control group. Enlarged ventricles are associated with damage to central brain areas and the pre-frontal cortex, this damage is associated with negative symptoms of schizophrenia
Neural correlates – AO3
:) Research to support the role of neural correlates as an explanation for schizophrenia comes from Suddath et al. (1990). He used MRI scans to investigate the brain structure of MZ twins in which one twin was schizophrenic. They found that the schizophrenic twin generally had more enlarged ventricles. This suggests enlarged ventricles do play a role in determining the likelihood of schizophrenia developing.
Biological explanation- Neural Correlates: Dopamine Hypothesis
The brains chemical messengers (neurotransmitters) appear to work differently in the brain of a patient with schizophrenia. In particular, Dopamine is widely believed to be involved as individuals with sz may release too much dopamine or have a large amount of D2 receptors on the post synaptic neuron
Hyperdopaminergia in the subcortex: High dopamine activity in the central areas of the brain such as Broca’s area may be associated with auditory hallucinations.
Hypodopaminergia in the cortex: Low dopamine activity in the prefrontal cortex have been associated with the negative symptoms of schizophrenia such as avolition.
It has been suggested that cortical hypodopaminergia leads to subcortical hyperdopaminergia. Both high and low levels of dopamine in different brain regions are involved in different symptoms of schizophrenia.
Biological explanation of schizophrenia - AO3
:) A strength of the biological explanation of schizophrenia is that it uses scientific methods. This is because the theory is based on objective and empirical techniques such as gene mapping studies and brain scans such as FMRI which are used to identify specific genes (PCM1) or areas of the brain linked to schizophrenia (enlarged ventricles). Therefore, this increases the overall internal validity of the biological explanation of schizophrenia, thus, raising Psychology’s scientific status.
:( However, the biological explanation of schizophrenia can be criticised for biological determinism, this is because the theory states that an individual is controlled by internal factors such as high dopamine activity (hyperdopaminergia) in the subcortex which inevitably causes auditory hallucinations. Therefore, it neglects the role of free will, and choice that individuals have; this could leave victims feeling like they have no control over their schizophrenic behaviour. THINK FURTHER. Furthermore, it be seen as unethical as it can leave victims’ families feeling guilty as they have passed on a gene that has affected their children and it cannot be stopped. Therefore, this limits the biological explanation of schizophrenia.
:) A strength of the biological explanation of schizophrenia is that it has practical applications. This is because the principles of the theory, that schizophrenia is caused by an imbalance of dopamine has led to the treatment of drug therapies such as typical and atypical antipsychotics. These drugs are effective in treating schizophrenia by balancing levels of dopamine in the patient’s brain and therefore reducing symptoms of schizophrenia such as hallucinations and delusions. Therefore the biological explanation of schizophrenia is an important part of applied psychology as it helps to treat people in the real world.
Drug therapy: typical antipsychotics
Typical antipsychotics e.g. CHLORPROMAZINE
First generation antipsychotics such as Chlorpromazine are dopamine antagonists; they reduce levels of dopamine activity in the brain. Chlorpromazine works by binding to the D2 receptors on post synaptic neurons in the brain, reducing the action of dopamine. This reduces dopamine activity levels and results in a reduction of positive symptoms of schizophrenia, such as hallucinations. They are also used as a sedative and can be used to calm patients
Drug therapy: atypical antipsychotics
Atypical antipsychotics e.g. CLOZAPINE
Second generation antipsychotics act upon dopamine AND serotonin. Clozapine also binds to D2 dopamine receptor sites on the post synaptic neuron, reducing positive symptoms such as hallucinations. They also act as agonists upon serotonin receptor sites (2A and 2C) to increase levels of serotonin. It is believed that this action reduces negative symptoms of schizophrenia such as a lack of emotions as it helps improve mood and reduce depression and anxiety in patients.
why typical antipsychotics are used
atypical antipsychotics (clozapine) are associated with a life-threatening illness (agranulocytosis). Therefore, they are only given if typical antipsychotics (chlorpromazine) are not effective or if the patient has severe negative side effects (suicidal ideation).
If the patient is prescribed atypical antipsychotics (clozapine) they will be regularly monitored for signs of agranulocytosis by having blood tests.
However, Typical antipsychotics can give patients Parkinsonism (Parkinson like symptoms). This affects the patients motor movements and be quite distressing to a previously fit and able individual.
Drug Therapy: typical and atypical antipsychotics – AO3
:) A strength of antipsychotics as a treatment for Schizophrenia is that there is evidence to support their effectiveness. There is a large body of research to support the effectiveness of typical and atypical antipsychotics. Thornley et al (2003) found that a meta-analysis of 13 studies with a total of 1121 participants investigating Chlorpromazine (typical) against a placebo, that the typical antipsychotic was associated with better overall functioning and reduced symptom severity. Furthermore, Meltzer (2012) concluded that Clozapine (atypical) was more effective than typical antipsychotics and is effective in 30-50% of treatment resistant cases. Therefore, supporting that antipsychotics are an effective treatment for positive and negative symptoms of Schizophrenia.
:( A weakness of using drug therapy to treat Schizophrenia is that they can cause negative side effects. Typical antipsychotics such as chlorpromazine can produce movement side effects such as parkinsonism (Parkinson-like symptoms), moreover atypical antipsychotics carry the risk of a life-threatening illness, agranulocytosis (reduced white blood cell count). Unlike CBT, as this involves a person identifying and challenging their irrational thoughts (delusions), without the use of drugs so there are no negative and potentially life-threatening side effects. Therefore, drug therapy may not be appropriate for all patients as the side effects reduce the effectiveness of drug therapy as a treatment of schizophrenia as some people may stop taking them resulting in relapse of symptoms.
:) A strength of drug therapy as a treatment for SZ, is that typical and atypical antipsychotics require little motivation from the patient. This is because the patient only has to take a tablet in order to reduce the symptoms of schizophrenia. This is unlike Cognitive Behaviour Therapy which requires motivation from patients as they have to attend sessions and engage in them in order to identify and challenge irrational thoughts such as delusions. This may be difficult for a person with schizophrenia as they may not have an accurate perception of reality. Further to this, it is beneficial for those with negative symptoms such as Avolition who struggle with keeping up with everyday tasks as they receive immediate positive effects on their symptoms. Therefore, drug therapy may be more appropriate than CBT in treating schizophrenia BECAUSE it is a more accessible treatment across the symptoms.
Psychological explanations- Family dysfunction essay intro
Family dysfunction is the idea that an individual develops schizophrenia because they have been raised in a dysfunctional family environment. The family is dysfunctional in the way that they communicate with each other as they have high levels of tension and arguments. This results in creating risk factors for the development and maintenance of schizophrenia
Psychological explanations- Family dysfunction: Schizophrenogenic mother
The idea that schizophrenia is caused by the patient’s early experience of a schizophrenogenic mother
A schizophrenogenic mother is cold, controlling, rejecting, emotionally unresponsive and builds a family climate characterised by tension and secrecy. This leads to distrust that later develops into paranoid delusions (positive symptom) in schizophrenia.
The father in such families is often passive.